Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lachlan R. Gray"'
Autor:
Christina Fichter, Anupriya Aggarwal, Andrew Kam Ho Wong, Samantha McAllery, Vennila Mathivanan, Bailey Hao, Hugh MacRae, Melissa J. Churchill, Paul R. Gorry, Michael Roche, Lachlan R. Gray, Stuart Turville
Publikováno v:
Viruses, Vol 13, Iss 6, p 1170 (2021)
Gene/cell therapies are promising strategies for the many presently incurable diseases. A key step in this process is the efficient delivery of genes and gene-editing enzymes to many cell types that may be resistant to lentiviral vector transduction.
Externí odkaz:
https://doaj.org/article/510f69023d3149dab5d7075c90f1bb38
Autor:
Hao K Lu, Lachlan R Gray, Fiona Wightman, Paula Ellenberg, Gabriela Khoury, Wan-Jung Cheng, Talia M Mota, Steve Wesselingh, Paul R Gorry, Paul U Cameron, Melissa J Churchill, Sharon R Lewin
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113341 (2014)
Histone deacetylase inhibitors (HDACi) can induce human immunodeficiency virus (HIV) transcription from the HIV long terminal repeat (LTR). However, ex vivo and in vivo responses to HDACi are variable and the activity of HDACi in cells other than T-c
Externí odkaz:
https://doaj.org/article/c16fc67732414344aaa08c353fa9b9b6
Autor:
Martin R Jakobsen, Kieran Cashin, Michael Roche, Jasminka Sterjovski, Anne Ellett, Katharina Borm, Jacqueline Flynn, Christian Erikstrup, Maelenn Gouillou, Lachlan R Gray, Nitin K Saksena, Bin Wang, Damian F J Purcell, Per Kallestrup, Rutendo Zinyama-Gutsire, Exnevia Gomo, Henrik Ullum, Lars Ostergaard, Benhur Lee, Paul A Ramsland, Melissa J Churchill, Paul R Gorry
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65950 (2013)
HIV-1 subtype C (C-HIV) is responsible for most HIV-1 cases worldwide. Although the pathogenesis of C-HIV is thought to predominantly involve CCR5-restricted (R5) strains, we do not have a firm understanding of how frequently CXCR4-using (X4 and R5X4
Externí odkaz:
https://doaj.org/article/525cf670b2d0493c8f826bf7da83c7e4
Autor:
Samantha McAllery, Stuart Turville, Bailey Hao, Melissa J Churchill, Christina Fichter, Paul R Gorry, Vennila Mathivanan, Andrew Kam Ho Wong, Hugh H. MacRae, Anupriya Aggarwal, Lachlan R Gray, Michael Roche
Publikováno v:
Viruses
Volume 13
Issue 6
Viruses, Vol 13, Iss 1170, p 1170 (2021)
Volume 13
Issue 6
Viruses, Vol 13, Iss 1170, p 1170 (2021)
Gene/cell therapies are promising strategies for the many presently incurable diseases. A key step in this process is the efficient delivery of genes and gene-editing enzymes to many cell types that may be resistant to lentiviral vector transduction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9eb9574304c686fe31ac0c466a834b
https://doi.org/10.3390/v13061170
https://doi.org/10.3390/v13061170
Publikováno v:
Current opinion in HIV and AIDS. 11(4)
Purpose of review: To review current knowledge of viral reservoirs in the central nervous system (CNS) and identify the CNS-specific barriers and strategies to cure human immunodeficiency virus type 1 (HIV-1) within the brain. Recent findings: The cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583effa0ece3618c0e427e2edb31c481
https://pubmed.ncbi.nlm.nih.gov/26945147
https://pubmed.ncbi.nlm.nih.gov/26945147
Autor:
Lachlan R Gray, Stuart G Turville, Tina L Hitchen, Wan-Jung Cheng, Anne M Ellett, Hamid Salimi, Michael J Roche, Steve L Wesselingh, Paul R Gorry, Melissa J Churchill
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90620 (2014)
Astrocytes are extensively infected with HIV-1 in vivo and play a significant role in the development of HIV-1-associated neurocognitive disorders. Despite their extensive infection, little is known about how astrocytes become infected, since they la
Externí odkaz:
https://doaj.org/article/8eba2162e2f944e3b4f5387b7505d61f
The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes.
Autor:
Lachlan R Gray, Gilda Tachedjian, Anne M Ellett, Michael J Roche, Wan-Jung Cheng, Gilles J Guillemin, Bruce J Brew, Stuart G Turville, Steve L Wesselingh, Paul R Gorry, Melissa J Churchill
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62196 (2013)
HIV-1 establishes infection in astrocytes and macroage-lineage cells of the central nervous system (CNS). Certain antiretroviral drugs (ARVs) can penetrate the CNS, and are therefore often used in neurologically active combined antiretroviral therapy
Externí odkaz:
https://doaj.org/article/d97c6377d27544618061aac3fbdc631d