Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lachlan P. Deimel"'
Autor:
Lachlan P. Deimel, Lucile Moynié, Guoxuan Sun, Viliyana Lewis, Abigail Turner, Charles J. Buchanan, Sean A. Burnap, Mikhail Kutuzov, Carolin M. Kobras, Yana Demyaneko, Shabaz Mohammed, Mathew Stracy, Weston B. Struwe, Andrew J. Baldwin, James Naismith, Benjamin G. Davis, Quentin J. Sattentau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Many archetypal and emerging classes of small-molecule therapeutics form covalent protein adducts. In vivo, both the resulting conjugates and their off-target side-conjugates have the potential to elicit antibodies, with implications for all
Externí odkaz:
https://doaj.org/article/cfce8b6432ac440bba75dc9b6023863a
Autor:
Linnea Z. Drexhage, Shengpan Zhang, Maeva Dupont, Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero, Lachlan P. Deimel, Helen Robertson, Rebecca A. Russell, Omer Dushek, Erdinc Sezgin, Niloofar Karaji, Quentin J. Sattentau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Efferocytic clearance of apoptotic cells in general, and T cells in particular, is required for tissue and immune homeostasis. Transmembrane mucins are extended glycoproteins highly expressed in the cell glycocalyx that function as a barrier
Externí odkaz:
https://doaj.org/article/a78c3489d25b4a7b8a6eb636c18d4b52
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract IL-4 production is associated with low-avidity, poorly cytotoxic T cell induction that contributes to viral immune evasion and the failure of T cell-based vaccines. Yet, the precise mechanisms that regulate IL-4 signalling in T cells remain
Externí odkaz:
https://doaj.org/article/9d3a69cae7d44875ab35f73cf32c12c7
Autor:
Lachlan P. Deimel, Xin Liu, Javier Gilbert-Jaramillo, Sai Liu, William S. James, Quentin J. Sattentau
Publikováno v:
Journal of Immunological Methods. 511:113380
The SARS-CoV-2 pandemic continues despite the presence of effective vaccines, and novel vaccine approaches may help to reduce viral spread and associated COVID-19 disease. Current vaccine administration modalities are based on systemic needle-adminis
Autor:
Sergio Daga, Alessandra Renieri, Philip N. Ward, Simone Furini, Lachlan P. Deimel, Raymond J. Owens, Alexandre M. J. J. Bonvin, Francesca Fava, Jiwei Liu, Georgios Papadakis, Kapil Gupta, Marco Gori, Quentin J. Sattentau, Margherita Baldassarri, Aziz Khan, Andrew Baldwin, Elisa Benetti, Gen-Covid Multicenter Study, Ben Gaunt, Christiane Schaffitzel, Yun Yang, Jiandong Huo, Maud Dumoux, Charles J. Buchanan, Benjamin G. Davis, Andrew M. Giltrap, Virginia Casablancas-Antras, Panagiotis I. Koukos, Peter J. Harrison, Annarita Giliberti, Abirami Lakshminarayanan, Xiaochao Xue, Nicola Picchiotti, Chiara Fallerini, Timothy D. W. Claridge, Imre Berger, Audrey Le Bas, James H. Naismith
Many host pathogen interactions such as human viruses (including non-SARS-coronaviruses) rely on attachment to host cell-surface glycans. There are conflicting reports about whether the Spike protein of SARS-CoV-2 binds to sialic acid commonly found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aae057b82835829fd011b653b1c2b7d1
https://doi.org/10.1101/2021.04.14.439284
https://doi.org/10.1101/2021.04.14.439284
Publikováno v:
Trends in Microbiology
Glycans are repeating carbohydrate structures added as post-translational modifications (PTMs) to proteins, forming glycoproteins. Self-glycans found on human cells, and viral glycoproteins produced in host cells, are generally weakly immunogenic, wh