Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Lachlan J. M. Coin"'
Autor:
Mark R. Davies, Nadia Keller, Stephan Brouwer, Magnus G. Jespersen, Amanda J. Cork, Andrew J. Hayes, Miranda E. Pitt, David M. P. De Oliveira, Nichaela Harbison-Price, Olivia M. Bertolla, Daniel G. Mediati, Bodie F. Curren, George Taiaroa, Jake A. Lacey, Helen V. Smith, Ning-Xia Fang, Lachlan J. M. Coin, Kerrie Stevens, Steven Y. C. Tong, Martina Sanderson-Smith, Jai J. Tree, Adam D. Irwin, Keith Grimwood, Benjamin P. Howden, Amy V. Jennison, Mark J. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
A variant of group A Streptococcus serotype M1 (UK) has been increasingly reported and can be differentiated from the global variant by its overexpression of the superantigen SpeA. Here, Davies et al probe the mechanism behind enhanced SpeA expressio
Externí odkaz:
https://doaj.org/article/c8e8696ec17643b4a4f2990cdf959bbe
Autor:
Devika Ganesamoorthy, Alan James Robertson, Wenhan Chen, Michael B. Hall, Minh Duc Cao, Kaltin Ferguson, Sunil R. Lakhani, Katia Nones, Peter T. Simpson, Lachlan J. M. Coin
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Circulating cell-free DNA (cfDNA) in the plasma of cancer patients contains cell-free tumour DNA (ctDNA) derived from tumour cells and it has been widely recognized as a non-invasive source of tumour DNA for diagnosis and prognosi
Externí odkaz:
https://doaj.org/article/7c33650a162849c0917d3be7602f54e8
Autor:
Jessie J.-Y. Chang, Josie Gleeson, Daniel Rawlinson, Ricardo De Paoli-Iseppi, Chenxi Zhou, Francesca L. Mordant, Sarah L. Londrigan, Michael B. Clark, Kanta Subbarao, Timothy P. Stinear, Lachlan J. M. Coin, Miranda E. Pitt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Better methods to interrogate host-pathogen interactions during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections are imperative to help understand and prevent this disease. Here we implemented RNA-sequencing (RNA-seq) using Oxf
Externí odkaz:
https://doaj.org/article/ff91d0e812a142edac168609ab6f1ff1
Autor:
Adam D. Irwin, Lachlan J. M. Coin, Patrick N. A. Harris, Menino Osbert Cotta, Michelle J. Bauer, Cameron Buckley, Ross Balch, Peter Kruger, Jason Meyer, Kiran Shekar, Kara Brady, Cheryl Fourie, Natalie Sharp, Luminita Vlad, David Whiley, Scott A. Beatson, Brian M. Forde, David Paterson, Julia Clark, Krispin Hajkowicz, Sainath Raman, Seweryn Bialasiewicz, Jeffrey Lipman, Luregn J. Schlapbach, Jason A. Roberts
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
BackgroundSepsis contributes significantly to morbidity and mortality globally. In Australia, 20,000 develop sepsis every year, resulting in 5,000 deaths, and more than AUD$846 million in expenditure. Prompt, appropriate antibiotic therapy is effecti
Externí odkaz:
https://doaj.org/article/3d6f82630f734f6080f3b612022a58d8
Autor:
Seweryn Bialasiewicz, Tania P. S. Duarte, Son H. Nguyen, Vichitra Sukumaran, Alexandra Stewart, Sally Appleton, Miranda E. Pitt, Arnold Bainomugisa, Amy V. Jennison, Rikki Graham, Lachlan J. M. Coin, Krispin Hajkowicz
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-5 (2019)
Abstract Background Rapid diagnosis and appropriate treatment is imperative in bacterial sepsis due increasing risk of mortality with every hour without appropriate antibiotic therapy. Atypical infections with fastidious organisms may take more than
Externí odkaz:
https://doaj.org/article/2526c54e7d36480bb1638b33a4552740
Autor:
Shan Wu, Kin H. Lau, Qinghe Cao, John P. Hamilton, Honghe Sun, Chenxi Zhou, Lauren Eserman, Dorcus C. Gemenet, Bode A. Olukolu, Haiyan Wang, Emily Crisovan, Grant T. Godden, Chen Jiao, Xin Wang, Mercy Kitavi, Norma Manrique-Carpintero, Brieanne Vaillancourt, Krystle Wiegert-Rininger, Xinsun Yang, Kan Bao, Jennifer Schaff, Jan Kreuze, Wolfgang Gruneberg, Awais Khan, Marc Ghislain, Daifu Ma, Jiming Jiang, Robert O. M. Mwanga, Jim Leebens-Mack, Lachlan J. M. Coin, G. Craig Yencho, C. Robin Buell, Zhangjun Fei
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Sweetpotato is an important food security crop providing rich source of macro- and micronutrients including carbohydrates and vitamins. Here, the authors assemble of the two diploid relatives of cultivated sweetpotato and identify genes and alleles a
Externí odkaz:
https://doaj.org/article/687ac8e03d8244e6bbce8b0bef8a94db
Autor:
Chenxi Zhou, Tania Duarte, Rocio Silvestre, Genoveva Rossel, Robert O. M. Mwanga, Awais Khan, Andrew W. George, Zhangjun Fei, G. Craig Yencho, David Ellis, Lachlan J. M. Coin
Publikováno v:
Gates Open Research, Vol 2 (2020)
Background: The chloroplast (cp) genome is an important resource for studying plant diversity and phylogeny. Assembly of the cp genomes from next-generation sequencing data is complicated by the presence of two large inverted repeats contained in the
Externí odkaz:
https://doaj.org/article/7c2e31a351ba4593bd81d3bc0cc3ea88
Autor:
Haojing Shao, Devika Ganesamoorthy, Tania Duarte, Minh Duc Cao, Clive J. Hoggart, Lachlan J. M. Coin
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Detection of genomic inversions remains challenging. Many existing methods primarily target inzversions with a non repetitive breakpoint, leaving inverted repeat (IR) mediated non-allelic homologous recombination (NAHR) inversions
Externí odkaz:
https://doaj.org/article/289b03073ae347348dad1be5ba497706
Autor:
Minh Duc Cao, Son Hoang Nguyen, Devika Ganesamoorthy, Alysha G. Elliott, Matthew A. Cooper, Lachlan J. M. Coin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Assembling genomes using currently available computational methods can be time consuming. Here, Coin and colleagues describe a bioinformatics tool named npScarf that can scaffold and complete an existing short read assembly in real-time using nanopor
Externí odkaz:
https://doaj.org/article/6ae502fb25914ebfb2682688ad60502a
Autor:
Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Kirsi Sipilä, Raija Lähdesmäki, Iona Y. Millwood, Marika Kaakinen, Gopalakrishnan Netuveli, David Blane, Pimphen Charoen, Ulla Sovio, Anneli Pouta, Nelson Freimer, Anna-Liisa Hartikainen, Jaana Laitinen, Sarianna Vaara, Beate Glaser, Peter Crawford, Nicholas J. Timpson, Susan M. Ring, Guohong Deng, Weihua Zhang, Mark I. McCarthy, Panos Deloukas, Leena Peltonen, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin
Publikováno v:
PLoS Genetics, Vol 6, Iss 3 (2010)
Externí odkaz:
https://doaj.org/article/a80155e3186540cca451593b1647a7aa