Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Lachlan Harris"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S84-S85 (2023)
Externí odkaz:
https://doaj.org/article/b9cf13e340704aa88df3397cd6cb09d0
Autor:
Kreepa G. Kooblall, Mark Stevenson, Michelle Stewart, Lachlan Harris, Oressia Zalucki, Hannah Dewhurst, Natalie Butterfield, Houfu Leng, Tertius A. Hough, Da Ma, Bernard Siow, Paul Potter, Roger D. Cox, Stephen D.M. Brown, Nicole Horwood, Benjamin Wright, Helen Lockstone, David Buck, Tonia L. Vincent, Fadil M. Hannan, J.H. Duncan Bassett, Graham R. Williams, Kate E. Lines, Michael Piper, Sara Wells, Lydia Teboul, Raoul C. Hennekam, Rajesh V. Thakker
Publikováno v:
JBMR Plus, Vol 7, Iss 6, Pp n/a-n/a (2023)
The nuclear factor I/X (NFIX) gene encodes a ubiquitously expressed transcription factor whose mutations lead to two allelic disorders characterized by developmental, skeletal, and neural abnormalities, namely, Malan syndrome (MAL) and Marshall–Smi
Externí odkaz:
https://doaj.org/article/e6e65049660d4723b8974df714e0b83f
Publikováno v:
Photonics, Vol 10, Iss 1, p 27 (2022)
A readily configurable and scalable 2 µm laser source with multi-channel/wavelength fiber output could be advantageous to 2 µm applications such as spectral-beam combination or fiber communications. We report the first experimental realization and
Externí odkaz:
https://doaj.org/article/d36caa8d87f64aeabd6daed84180e559
Autor:
Elise Matuzelski, Alexandra Essebier, Lachlan Harris, Richard M. Gronostajski, Tracey J. Harvey, Michael Piper
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-3 (2020)
Abstract Objective Nuclear Factor One X (NFIX) is a transcription factor expressed by neural stem cells within the developing mouse brain and spinal cord. In order to characterise the pathways by which NFIX may regulate neural stem cell biology withi
Externí odkaz:
https://doaj.org/article/a0ce9aefc2004715a118f6a8f2a8406f
Heterozygosity for Nuclear Factor One X in mice models features of Malan syndromeResearch in context
Autor:
Sabrina Oishi, Danyon Harkins, Nyoman D. Kurniawan, Maria Kasherman, Lachlan Harris, Oressia Zalucki, Richard M. Gronostajski, Thomas H.J. Burne, Michael Piper
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 388-400 (2019)
Background: Nuclear Factor One X (NFIX) haploinsufficiency in humans results in Malan syndrome, a disorder characterized by overgrowth, macrocephaly and intellectual disability. Although clinical assessments have determined the underlying symptomolog
Externí odkaz:
https://doaj.org/article/24d77e45fada4e82a4a45207064c7dc1
Autor:
Charles Arber, Christopher Lovejoy, Lachlan Harris, Nanet Willumsen, Argyro Alatza, Jackie M. Casey, Georgie Lines, Caoimhe Kerins, Anika K. Mueller, Henrik Zetterberg, John Hardy, Natalie S. Ryan, Nick C. Fox, Tammaryn Lashley, Selina Wray
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108615- (2021)
Summary: Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of γ-secretase, cause familial Alzheimer’s disease (fAD). We hypothesized that mutations in PSEN1 reduce Notch signaling and alter neurogenesis. Expression d
Externí odkaz:
https://doaj.org/article/7f979cc3b908483da5f10f85ac910f06
Autor:
Oressia Zalucki, Danyon Harkins, Lachlan Harris, Thomas H. J. Burne, Richard M. Gronostajski, Michael Piper
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)
Abstract Objective The active place avoidance task (APA) is a behavioural task used to assess learning and memory in rodents. This task relies on the hippocampus, a region of the cerebral cortex capable of generating new neurons from neural stem cell
Externí odkaz:
https://doaj.org/article/67b9fc24f04440d99e9584e97e3ba863
Autor:
Mitchell E. Fane, Yash Chhabra, David E.J. Hollingsworth, Jacinta L. Simmons, Loredana Spoerri, Tae Gyu Oh, Jagat Chauhan, Toby Chin, Lachlan Harris, Tracey J. Harvey, George E.O. Muscat, Colin R. Goding, Richard A Sturm, Nikolas K. Haass, Glen M. Boyle, Michael Piper, Aaron G. Smith
Publikováno v:
EBioMedicine, Vol 16, Iss C, Pp 63-75 (2017)
While invasion and metastasis of tumour cells are the principle factor responsible for cancer related deaths, the mechanisms governing the process remain poorly defined. Moreover, phenotypic divergence of sub-populations of tumour cells is known to u
Externí odkaz:
https://doaj.org/article/1d9c7e7e95224d40a32f42bb4b0ce6d1
Publikováno v:
Stem Cells International, Vol 2016 (2016)
The cerebral cortex is essential for our higher cognitive functions and emotional reasoning. Arguably, this brain structure is the distinguishing feature of our species, and yet our remarkable cognitive capacity has seemingly come at a cost to the re
Externí odkaz:
https://doaj.org/article/ead6a7639ab7453ba006b71eb2ae057c
Autor:
Lachlan Harris, Chantelle Dixon, Kathleen Cato, Yee Hsieh Evelyn Heng, Nyoman D Kurniawan, Jeremy F P Ullmann, Andrew L Janke, Richard M Gronostajski, Linda J Richards, Thomas H J Burne, Michael Piper
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65478 (2013)
Identification of the genes that regulate the development and subsequent functioning of the hippocampus is pivotal to understanding the role of this cortical structure in learning and memory. One group of genes that has been shown to be critical for
Externí odkaz:
https://doaj.org/article/bbb266f2644f4dfa9fad067df7de0b08