Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Lachlan D, Rash"'
Autor:
Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, o
Externí odkaz:
https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Peripheral and central immune cells are critical for fighting disease, but they can also play a pivotal role in the onset and/or progression of a variety of neurological conditions that affect the central nervous system (CNS). Tissue acidosis is ofte
Externí odkaz:
https://doaj.org/article/ef6929ecacbf4544b0549b76f6ba5c95
Autor:
Joshua S. Wingerd, Christine A. Mozar, Christine A. Ussing, Swetha S. Murali, Yanni K.-Y. Chin, Ben Cristofori-Armstrong, Thomas Durek, John Gilchrist, Christopher W. Vaughan, Frank Bosmans, David J. Adams, Richard J. Lewis, Paul F. Alewood, Mehdi Mobli, Macdonald J. Christie, Lachlan D. Rash
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Voltage-gated sodium (NaV) channels are essential for the transmission of pain signals in humans making them prime targets for the development of new analgesics. Spider venoms are a rich source of peptide modulators useful to study ion chann
Externí odkaz:
https://doaj.org/article/f33655e710d64fada2b711f3a0de8577
Autor:
Lachlan D. Rash, Stephan Kellenberger
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Acid-sensing ion channels (ASICs, nomenclature as agreed by NC-IUPHAR [48, 2, 3]) are members of a Na+ channel superfamily that includes the epithelial Na+ channel (ENaC), the FMRF-amide activated channel (FaNaC) of invertebrates, the degenerins (DEG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2391cadc5dc2fcad2fb175bbc5fae99d
https://doi.org/10.2218/gtopdb/f118/2023.1
https://doi.org/10.2218/gtopdb/f118/2023.1
Autor:
Chun Yuen Chow, Ben Cristofori-Armstrong, Eivind A. B. Undheim, Glenn F. King, Lachlan D. Rash
Publikováno v:
Toxins, Vol 7, Iss 7, Pp 2494-2513 (2015)
Voltage-gated sodium (NaV) channels are responsible for propagating action potentials in excitable cells. NaV1.7 plays a crucial role in the human pain signalling pathway and it is an important therapeutic target for treatment of chronic pain. Numero
Externí odkaz:
https://doaj.org/article/8989c5648e5d4c31bbd0c633f90b6053
The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.
Autor:
Sassan Rahnama, Jennifer R Deuis, Fernanda C Cardoso, Venkatraman Ramanujam, Richard J Lewis, Lachlan D Rash, Glenn F King, Irina Vetter, Mehdi Mobli
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173551 (2017)
Venom-derived peptides have attracted much attention as potential lead molecules for pharmaceutical development. A well-known example is Huwentoxin-IV (HwTx-IV), a peptide toxin isolated from the venom of the Chinese bird-eating spider Haplopelma sch
Externí odkaz:
https://doaj.org/article/df41c8b4e37143b68c0e5ea483a42562
Autor:
Rahini Kakumanu, Sanjaya Kuruppu, Lachlan D. Rash, Geoffrey K. Isbister, Wayne C. Hodgson, Barbara K. Kemp-Harper
Publikováno v:
Toxins, Vol 11, Iss 4, p 197 (2019)
Russell’s viper (Daboia russelii) venom causes a range of clinical effects in humans. Hypotension is an uncommon but severe complication of Russell’s viper envenoming. The mechanism(s) responsible for this effect are unclear. In this study, we ex
Externí odkaz:
https://doaj.org/article/65e133e63495484a97a54c1571791ca9
Autor:
Rocio K. Finol-Urdaneta, Rebekah Ziegman, Zoltan Dekan, Jeffrey R. McArthur, Stewart Heitmann, Karen Luna-Ramirez, Han-Shen Tae, Alexander Mueller, Hana Starobova, Yanni K.-Y. Chin, Joshua S. Wingerd, Eivind A. B. Undheim, Ben Cristofori-Armstrong, Adam P. Hill, Volker Herzig, Glenn F. King, Irina Vetter, Lachlan D. Rash, David J. Adams, Paul F. Alewood
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Pain development and discomfort are universal features of spider envenomation, yet severe pain arising from bites by Old World spiders is poorly understood. Molecular analyses of the venom of the King Baboon spider revealed abundant expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b39880bcca9700b1b3fe917c377bea
https://hdl.handle.net/11250/3058935
https://hdl.handle.net/11250/3058935
Publikováno v:
Marine Drugs, Vol 10, Iss 7, Pp 1511-1527 (2012)
APETx2 is a peptide isolated from the sea anemone Anthopleura elegantissima. It is the most potent and selective inhibitor of acid-sensing ion channel 3 (ASIC3) and it is currently in preclinical studies as a novel analgesic for the treatment of chro
Externí odkaz:
https://doaj.org/article/42627fb81e9b4280b180887c15b87a5b
Publikováno v:
Marine Drugs, Vol 10, Iss 7, Pp 1605-1618 (2012)
Acid-sensing ion channels (ASICs) are proton-gated sodium channels present in the central and peripheral nervous system of chordates. ASIC3 is highly expressed in sensory neurons and plays an important role in inflammatory and ischemic pain. Thus, sp
Externí odkaz:
https://doaj.org/article/96e847e8f9e44dcc9fefc8bd0145236b