Human Omental Mesothelial Cells Impart an Immunomodulatory Landscape Impeding B- and T-Cell Activation

Autor: Gauthier BR, Rubio-Contreras D, Gómez-Rosado JC, Capitán-Morales LC, Hmadcha A, Soria B, Lachaud CC

Publikováno v: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname

Mesothelial cells form the mesothelium, a simple epithelium lining the walls of serous cavities and the surface of visceral organs. Although mesothelial cells are phenotypically well characterized, their immunoregulatory properties remain largely unk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::3b8c55cb870f6c045404e20a8a968ddc
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=9026

Use of Mesothelial Cells and Biological Matrices for Tissue Engineering of Simple Epithelium Surrogates

Autor: Lachaud, Christian Claude, Rodriguez-Campins, Berta, Hmadcha, Abdelkrim, Soria, Bernat

Journal Article; Review; Tissue-engineering technologies have progressed rapidly through last decades resulting in the manufacture of quite complex bioartificial tissues with potential use for human organ and tissue regeneration. The manufacture of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2636::bae4e80138e508c80e215ef6effb7d04
https://hdl.handle.net/10668/2251

Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation

Autor: Abdelkrim Hmadcha, Christian Claude Lachaud, Tim Guilliams, Adahir Labrador-Garrido, David Pozo, Elena Gonzalez-Rey, Cintia Roodveldt, Alicia Benitez-Rondan, Christopher M. Dobson, Rafael Fernandez-Montesinos, Gema Robledo, Mario Delgado

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE, Vol 8, Iss 11, p e79160 (2013)
PLoS ONE

Roodveldt, Cintia et al.
In recent years, it has become accepted that α-synuclein (αSyn) has a key role in the microglia-mediated neuroinflammation, which accompanies the development of Parkinson's disease and other related disorders, such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3adda19e78432ea6d60a5e249deb675
https://hdl.handle.net/10668/2279

The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity.

Autor: Lorenzo PI; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Martin Vazquez E; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., López-Noriega L; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Fuente-Martín E; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Mellado-Gil JM; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Franco JM; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Cobo-Vuilleumier N; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Guerrero Martínez JA; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Romero-Zerbo SY; Unidad de Gestión Clínica Intercentros de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Spain., Perez-Cabello JA; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Rivero Canalejo S; Department of Normal and Pathological Histology and Cytology, University of Seville School of Medicine, Seville, Spain., Campos-Caro A; University Hospital 'Puerta del Mar', Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA), Cádiz, Spain., Lachaud CC; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Crespo Barreda A; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Aguilar-Diosdado M; University Hospital 'Puerta del Mar', Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA), Cádiz, Spain.; Endocrinology and Metabolism Department, University Hospital 'Puerta del Mar', Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA), Cádiz, Spain., García Fuentes E; Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Spain., Martin-Montalvo A; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Álvarez Dolado M; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Martin F; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Rojo-Martinez G; Unidad de Gestión Clínica Intercentros de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Pozo D; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Bérmudez-Silva FJ; Unidad de Gestión Clínica Intercentros de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Comaills V; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Reyes JC; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Gauthier BR; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain.

Publikováno v: Theranostics [Theranostics] 2021 May 12; Vol. 11 (14), pp. 6983-7004. Date of Electronic Publication: 2021 May 12 (Print Publication: 2021).

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

Autor: Cobo-Vuilleumier N; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Lorenzo PI; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Rodríguez NG; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Herrera Gómez IG; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Fuente-Martin E; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., López-Noriega L; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Mellado-Gil JM; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Romero-Zerbo SY; Unidad de Gestión Clínica Intercentros de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, 29010, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28029, Spain., Baquié M; Neurix SA, Geneva, 1228, Switzerland., Lachaud CC; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Stifter K; Ulm University Hospital, Ulm, 89081, Germany., Perdomo G; Facultad de Ciencias de la Salud, Universidad de Burgos, Burgos, 09001, Spain., Bugliani M; Department Clinical and Experimental Medicine, University of Pisa-AOUP University Hospital, Pisa, 56126, Italy., De Tata V; Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, 56126, Italy., Bosco D; Cell Isolation and Transplantation Centre, University Hospital, Geneva, 1211, Switzerland., Parnaud G; Cell Isolation and Transplantation Centre, University Hospital, Geneva, 1211, Switzerland., Pozo D; Department of Cell Dynamics and Signalling, CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, 41092, Spain., Hmadcha A; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28029, Spain., Florido JP; Clinical Bioinformatics Area, Fundación Progreso y Salud, Consejería de Salud, Seville, 41013, Spain., Toscano MG; Amarna Therapeutics, Seville, 41092, Spain., de Haan P; Amarna Therapeutics, Seville, 41092, Spain., Schoonjans K; Laboratory of Metabolic Signaling, EPFL, Lausanne, 1015, Switzerland., Sánchez Palazón L; Biological Resources, CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, 41092, Spain., Marchetti P; Department Clinical and Experimental Medicine, University of Pisa-AOUP University Hospital, Pisa, 56126, Italy., Schirmbeck R; Ulm University Hospital, Ulm, 89081, Germany., Martín-Montalvo A; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Meda P; Department of Cell Physiology and Metabolism, University of Geneva, Geneva, 1211, Switzerland., Soria B; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28029, Spain., Bermúdez-Silva FJ; Unidad de Gestión Clínica Intercentros de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, 29010, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28029, Spain., St-Onge L; Neuried, Munich, 82061, Germany., Gauthier BR; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain. benoit.gauthier@cabimer.es.

Publikováno v: Nature communications [Nat Commun] 2018 Apr 16; Vol. 9 (1), pp. 1488. Date of Electronic Publication: 2018 Apr 16.