Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lacey Wright"'
Autor:
Manuel J. Carrasco, Suman Alishetty, Mohamad-Gabriel Alameh, Hooda Said, Lacey Wright, Mikell Paige, Ousamah Soliman, Drew Weissman, Thomas E. Cleveland, Alexander Grishaev, Michael D. Buschmann
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Carrasco et al. report a method that can predict the lipid nanoparticles (LNP) pKa from the structure of the ionizable lipid. They investigate the delivery efficiency for intramuscular and intravascular administration and propose design principles to
Externí odkaz:
https://doaj.org/article/bbdbf3686db74c9385304e3b47673ec7
Autor:
Omai B Garner, Hector C Aguilar, Jennifer A Fulcher, Ernest L Levroney, Rebecca Harrison, Lacey Wright, Lindsey R Robinson, Vanessa Aspericueta, Maria Panico, Stuart M Haslam, Howard R Morris, Anne Dell, Benhur Lee, Linda G Baum
Publikováno v:
PLoS Pathogens, Vol 6, Iss 7, p e1000993 (2010)
Nipah virus targets human endothelial cells via NiV-F and NiV-G envelope glycoproteins, resulting in endothelial syncytia formation and vascular compromise. Endothelial cells respond to viral infection by releasing innate immune effectors, including
Externí odkaz:
https://doaj.org/article/707371f4f80945cc8784ee99f52030aa
Autor:
Manuel J. Carrasco, Tomaz B. Manzoni, Suman Alishetty, Hooda Said, Paul Bates, Philip Hicks, Thomas E. Cleveland, Farhang Alem, Aarthi Narayanan, Drew Weissman, Ousamah Younoss Soliman, Mikell Paige, Patrick Gillevet, Alexander Grishaev, Keziah Hernandez, Mohamad-Gabriel Alameh, Michael D. Buschmann, Lacey Wright, Alisa Stephens-Shields
Concerns with current mRNA Lipid Nanoparticle (LNP) systems include dose-limiting reactogenicity, adverse events that may be partly due to systemic off target expression of the immunogen, and a very limited understanding of the mechanisms responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a3f29d0d19842ce51561cac8844acab
https://doi.org/10.21203/rs.3.rs-798453/v1
https://doi.org/10.21203/rs.3.rs-798453/v1
Autor:
Michael D. Buschmann, Thomas E. Cleveland, Drew Weissman, Hooda Said, Suman Alishetty, Alexander Grishaev, Lacey Wright, Ousamah Younoss Soliman, Manuel J. Carrasco, Mikell Paige, Mohamad-Gabriel Alameh
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the LNP containing an ionizable lipid. Herein, we report a method that can predict the LNP pKa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38555c1b6563ec824d49a9b2b4676d6
https://pubmed.ncbi.nlm.nih.gov/34381159
https://pubmed.ncbi.nlm.nih.gov/34381159
Akademický článek
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Autor:
Howard R. Morris, Lacey Wright, Ernest L. Levroney, Hector C. Aguilar, Stuart M. Haslam, Omai B. Garner, Rebecca Harrison, Linda G. Baum, Maria Panico, Lindsey R. Robinson, Anne Dell, Benhur Lee, Jonathan Fulcher, Vanessa Aspericueta
Publikováno v:
PLoS pathogens, vol 6, iss 7
Garner, OB; Aguilar, HC; Fulcher, JA; Levroney, EL; Harrison, R; Wright, L; et al.(2010). Endothelial Galectin-1 Binds to Specific Glycans on Nipah Virus Fusion Protein and Inhibits Maturation, Mobility, and Function to Block Syncytia Formation. PLOS PATHOGENS, 6(7). doi: 10.1371/journal.ppat.1000993. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1jm118wd
PLoS Pathogens, Vol 6, Iss 7, p e1000993 (2010)
Scopus-Elsevier
PLoS Pathogens
Garner, OB; Aguilar, HC; Fulcher, JA; Levroney, EL; Harrison, R; Wright, L; et al.(2010). Endothelial Galectin-1 Binds to Specific Glycans on Nipah Virus Fusion Protein and Inhibits Maturation, Mobility, and Function to Block Syncytia Formation. PLOS PATHOGENS, 6(7). doi: 10.1371/journal.ppat.1000993. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1jm118wd
PLoS Pathogens, Vol 6, Iss 7, p e1000993 (2010)
Scopus-Elsevier
PLoS Pathogens
Nipah virus targets human endothelial cells via NiV-F and NiV-G envelope glycoproteins, resulting in endothelial syncytia formation and vascular compromise. Endothelial cells respond to viral infection by releasing innate immune effectors, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b55ca199be1317815224755216528db
https://doi.org/10.1371/journal.ppat.1000993
https://doi.org/10.1371/journal.ppat.1000993