Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Lacey Samp"'
3
Scalable, Telescoped Hydrogenolysis–Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)-α-Heteroaryl Propionic Acids
Autor: Caroline A. Blakemore, Scott P. France, Lacey Samp, Deane M. Nason, Eddie Yang, Roger M. Howard, Karen J. Coffman, Qingyi Yang, Aaron C. Smith, Edelweiss Evrard, Wei Li, Linlin Dai, Lixia Yang, Zhiguang Chen, Qingli Zhang, Fangyan He, Jiesen Zhang
Publikováno v: Organic Process Research & Development. 25:421-426
Enantiopure α-aryl propionic acids are useful building blocks for pharmaceutical research and can be accessed enzymatically using arylmalonate decarboxylases (AMDases) from the corresponding maloni...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95e6ff3e3df541e059c49547d26b4819
https://doi.org/10.1021/acs.oprd.0c00397
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4
Stereoelectronic Effects in Ligand Design: Enantioselective Rhodium‐Catalyzed Hydrogenation of Aliphatic Cyclic Tetrasubstituted Enamides and Concise Synthesis of ( R )‐Tofacitinib
Autor: Feng Wan, Yuan Chen, Shu Yu, Chengxi Li, J. Christopher McWilliams, Henian Peng, Wenjun Tang, Lacey Samp, Jason Mustakis, Robert John Maguire
Publikováno v: Angewandte Chemie International Edition. 58:13573-13583
We herein report the development of a conformationally defined, electron-rich, C2 -symmetric, P-chiral bisphosphorus ligand, ArcPhos, by taking advantage of stereoelectronic effects in ligand design. With the Rh-ArcPhos catalyst, excellent enantiosel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280ce49de83eeb83a56544c585aa399f
https://doi.org/10.1002/anie.201908089
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5
Development of a Scalable Synthesis for an Inhaled pan-JAK Inhibitor
Autor: Alexander Gontcharov, Peter Jones, Steven W. Kortum, David Pattavina, Seungwon Chung, Peter Robert Rose, Jotham Wadsworth Coe, Tim L. Houck, Javier Magano, Lacey Samp, Anil Rane
Publikováno v: Organic Process Research & Development. 23:1990-2000
A scalable synthesis of a pan-JAK inhibitor is described. The original synthesis by the Medicinal Chemistry group has been modified to develop a new protecting group strategy, a 3-step telescoped s...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7f762a2b945aa1baf327c89d57a4b24
https://doi.org/10.1021/acs.oprd.9b00253
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6
Synthesis of Quinazolin-4(3H)-ones via Amidine N-Arylation
Autor: Cheryl Myers Hayward, Christine Yang, Lacey Samp, Bryan Li, John F. Sagal, Zhijun Zhang
Publikováno v: The Journal of Organic Chemistry. 78:1273-1277
Pyrido[4,3-d]pyrimidin-4(3H)-one (1) was prepared by reacting 2-trifluoromethyl-4-iodo-nicotinic acid (2) with amidine 9a catalyzed by Pd(2)(dba)(3) and Xantphos, followed by cyclization effected with HBTU and subsequent demethylation using PhBCl(2).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b333492662745ece7eae6a1b25c7c335
https://doi.org/10.1021/jo302515c
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7
Telescoped Flow Process for the Syntheses of N-Aryl Pyrazoles
Autor: Cheryl Myers Hayward, Brian T. O’Neil, Yanqiao Xiang, John VanAlsten, Daniel W. Widlicka, John C. Murray, Pfisterer David Michael, Steven J. Boucher, Joseph Michael Young, Lacey Samp, Bryan Li, John C. Lucas
Publikováno v: Organic Process Research & Development. 16:2031-2035
N-Aryl pyrazoles were prepared from anilines in a three step telescoped approach. An aniline was diazotized to give the diazonium fluoroborate, followed by reduction with tin(II) chloride to give the corresponding hydrazine, which in turn reacted wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68759d901664a19633cf8684b87f2982
https://doi.org/10.1021/op300209p
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