Systematic genetic and proteomic screens during gametogenesis identify H2BK34 methylation as an evolutionary conserved meiotic mark

Autor: Marion Crespo, Lacey J. Luense, Marie Arlotto, Jialei Hu, Jean Dorsey, Encar García-Oliver, Parisha P. Shah, Delphine Pflieger, Shelley L. Berger, Jérôme Govin

Publikováno v: Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-23 (2020)

Abstract Background Gametes are highly differentiated cells specialized to carry and protect the parental genetic information. During male germ cell maturation, histone proteins undergo distinct changes that result in a highly compacted chromatin org

Externí odkaz: https://doaj.org/article/63b9cbeb712f42c1b2b96fe0dd57f7a0

Systematic genetic and proteomic screens during gametogenesis identify H2BK34 methylation as an evolutionary conserved meiotic mark

Autor: Parisha P. Shah, Lacey J. Luense, Marie Arlotto, Encar García-Oliver, Shelley L. Berger, Jialei Hu, Jean Dorsey, Delphine Pflieger, Marion Crespo, Jérôme Govin

Publikováno v: Epigenetics & Chromatin
Epigenetics & Chromatin, BioMed Central, 2020, 13 (1), ⟨10.1186/s13072-020-00349-5⟩
Epigenetics & Chromatin, 2020, 13 (1), ⟨10.1186/s13072-020-00349-5⟩
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-23 (2020)

International audience; Background: Gametes are highly differentiated cells specialized to carry and protect the parental genetic information. During male germ cell maturation, histone proteins undergo distinct changes that result in a highly compact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb841e8f71a57ad6cf70aba6822658b4
https://hal.archives-ouvertes.fr/hal-02945586

Gcn5-Mediated Histone Acetylation Governs Nucleosome Dynamics in Spermiogenesis

Autor: Marisa S. Bartolomei, Lacey J. Luense, Richard Rangel, Greg Donahue, Angela H. Weller, Shelley L. Berger, Enrique Lin-Shiao

Publikováno v: Dev Cell

Summary During mammalian spermatogenesis, germ cell chromatin undergoes dramatic histone acetylation-mediated reorganization, whereby 90%–99% of histones are evicted. Given the potential role of retained histones in fertility and embryonic developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cbd8b23e389604ca85bc35277280ed
https://pubmed.ncbi.nlm.nih.gov/31761669

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence

Autor: Brian Frederick, Catherine Y. Li, Qijun Chen, Greg Donahue, Peter D. Adams, Weiwei Dang, Yemin Lan, Zhixun Dou, Shelley L. Berger, Payel Sen, F. Bradley Johnson, Lacey J. Luense, Benjamin A. Garcia, Simone Sidoli, David C. Schultz

Publikováno v: Molecular cell. 73(4)

Accumulation of senescent cells during aging contributes to chronic inflammation and age-related diseases. While senescence is associated with profound alterations of the epigenome, a systematic view of epigenetic factors in regulating senescence is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222df0492a4fe813e1b94878bf40cf70
https://pubmed.ncbi.nlm.nih.gov/30770903

Dicer1 Is Essential for Female Fertility and Normal Development of the Female Reproductive System

Autor: Xiaoman Hong, Warren B. Nothnick, Lynda K. McGinnis, Lacey J. Luense, Lane K. Christenson

Publikováno v: Endocrinology. 149:6207-6212

The ribonuclease III endonuclease, Dicer1 (also known as Dicer), is essential for the synthesis of the 19–25 nucleotide noncoding RNAs known as micro-RNAs (miRNAs). These miRNAs associate with the RNA-induced silencing complex to regulate gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c95c9e9e12c99467b4055c093212c0
https://doi.org/10.1210/en.2008-0294