Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lacey Hizartzidis"'
Autor:
Ahmed Al Otaibi, Adam McCluskey, Cecilia C. Russell, Lacey Hizartzidis, Fiona M. Deane, Jennette A. Sakoff, Siobhann N. McCluskey
Publikováno v:
RSC Advances. 9:7652-7663
The Ugi four component reaction of an aldehyde, amine, isocyanide and an ethanoic acid was effected smoothly in protic ionic liquids ethylammonium nitrate (EAN) and propylammonium nitrate (PAN) to afford analogues of α-phenylacetamido amides in good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63c82728fffbfcace601fe71fcddae3
https://doi.org/10.1039/c9ra00118b
https://doi.org/10.1039/c9ra00118b
Publikováno v:
ChemMedChem. 14(12)
Octahydroepoxyisoindole analogues of norcantharidin were accessed through a Diels-Alder reaction of an amine-substituted furan with maleic anhydride and subsequent reduction of the bicyclo[2.2.1]heptene olefin. Despite retention of the carboxylate an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd274b1e4de4a6f50a132068c3b716e
https://pubmed.ncbi.nlm.nih.gov/30938091
https://pubmed.ncbi.nlm.nih.gov/30938091
Publikováno v:
Organic & Biomolecular Chemistry. 13:7119-7130
There has been an increasing body of evidence that flow hydrogenation enhances reduction outcomes across a wide range of synthetic transformations. Moreover flow reactors enhance laboratory safety with pyrophoric catalysts contained in sealed cartrid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fee9c5b6de86d790b26c2aeac96234
https://doi.org/10.1039/c5ob01067e
https://doi.org/10.1039/c5ob01067e
Autor:
Adam McCluskey, Christopher P. Gordon, Lacey Hizartzidis, Mark J. Robertson, Michela I. Simone, Kelly A. Young, Peter J. Cossar
Publikováno v:
RSC Adv.. 4:56743-56748
A commonly observed limitation of conducting hydrogenations under flow chemistry conditions is hydrodehalogenation. In a bid to circumvent this limitation a series of hydrogenation catalysts were screened, with 5% Pt/C (sulfided) catalyst identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab9e6f215db787433de95025712eba40
https://doi.org/10.1039/c4ra09605c
https://doi.org/10.1039/c4ra09605c
Autor:
Christopher P. Gordon, Lacey Hizartzidis, Jennette A. Sakoff, Bronwyn E. Campbell, Robin B. Gasser, Jayne Gilbert, Mark Tarleton, Adam McCluskey
Publikováno v:
Med. Chem. Commun.. 5:159-164
We report the discovery of a series of acrylonitrile-containing molecules and α-amino amides which cause 99–100% lethality in H. contortus. Of the 22 acrylonitrile analogues investigated, the most active were 2-cyano-3-[1-(3-dimethylaminopropyl)-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df3ce58ea2328b1e1dad0270db50861d
https://doi.org/10.1039/c3md00255a
https://doi.org/10.1039/c3md00255a
Publikováno v:
ChemInform. 46
There has been an increasing body of evidence that flow hydrogenation enhances reduction outcomes across a wide range of synthetic transformations. Moreover flow reactors enhance laboratory safety with pyrophoric catalysts contained in sealed cartrid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f45532a4a008c5a0226b5e244be19a3
https://doi.org/10.1002/chin.201534270
https://doi.org/10.1002/chin.201534270
Autor:
Trieu N. Trinh, David G. Harman, Lacey Hizartzidis, Christopher P. Gordon, Andrew J. S. Lin, Adam McCluskey
Publikováno v:
Organicbiomolecular chemistry. 12(47)
Suzuki cross-couplings of 5-formyl-2-furanylboronic acid with activated or neutral aryl bromides were performed under continuous flow conditions in the presence of (Bu)4N(+)F(-) and the immobilised t-butyl based palladium catalyst CatCart™ FC1032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cc3d28528a1d0abe0d40565f0f2586
https://pubmed.ncbi.nlm.nih.gov/25333944
https://pubmed.ncbi.nlm.nih.gov/25333944
Publikováno v:
ChemInform. 45
Two series (VI) and (XI) of norcantharidin analogues are synthesized using continuous flow hydrogenation in key steps.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53b6b61211cbcdce45977bfb96ca3a90
https://doi.org/10.1002/chin.201442113
https://doi.org/10.1002/chin.201442113
Publikováno v:
ChemInform. 42
Four-component Ugi—Knoevenagel reaction of o-aminophenyl ketones (I) with aromatic aldehydes, cyanoacetic acid and isonitriles provides access towards polyfunctionalized quinolinones, e.g. (V) and (IX).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b84122103d59e97408b6f5653b0a33e
https://doi.org/10.1002/chin.201127160
https://doi.org/10.1002/chin.201127160
Publikováno v:
RSC Advances. 4:9709
Two libraries of highly decorated norcantharidin analogues were accessed via a series of sequential chemoselective flow hydrogenations and solvent-free transformations. Utilising a 10% Pd/C catalyst, modifications to reaction parameters (H2 pressure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c876205f89b1f2c2431b52a71812a875
https://doi.org/10.1039/c3ra47657j
https://doi.org/10.1039/c3ra47657j