Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Lacey, Johnson"'
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Cryopreservation significantly alters the phenotype of platelets; generating distinct subpopulations, which may influence the formation of platelet leukocyte aggregates (PLA). PLAs are immunomodulatory and have been associated with transfusion-associ
Externí odkaz:
https://doaj.org/article/27887a63323f40f5a6b7148696168080
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Cryopreservation of platelets, at − 80 °C with 5–6% DMSO, results in externalisation of phosphatidylserine and the formation of extracellular vesicles (EVs), which may mediate their procoagulant function. The phenotypic features of proc
Externí odkaz:
https://doaj.org/article/004ff84f68ed482faaa77734bd7ef9dc
Autor:
Denese C Marks, Lacey Johnson
Publikováno v:
Platelets, Vol 30, Iss 1, Pp 48-55 (2019)
Platelet concentrates for transfusion have a limited shelf-life, and cryopreservation offers a means of extending platelet shelf-life for at least 2 years. Cryopreservation, however, has some disadvantages, as platelets can be damaged during the free
Externí odkaz:
https://doaj.org/article/f329364b5d4d4363b8fa1f5d4421b715
Publikováno v:
Transfusion. 63
Publikováno v:
Transfusion. 61:3432-3442
BACKGROUND Cryopreserved platelets are under clinical evaluation as they offer improvements in shelf-life and potentially hemostatic effectiveness. However, the effect of cryopreservation on characteristics related to the immune function of platelets
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
Transfusions of platelets are an important cornerstone of medicine; however, recipients may be subject to risk of adverse events associated with the potential transmission of pathogens, especially bacteria. Pathogen inactivation (PI) technologies bas
Externí odkaz:
https://doaj.org/article/d74e583c8f53458298c2e2104cbafc4e
Publikováno v:
Vox sanguinisREFERENCES. 117(8)
BACKGROUND AND OBJECTIVES: Cold-stored platelets are currently under clinical evaluation and have been approved for limited clinical use in the United States. Most studies have focused on the haemostatic functionality of cold-stored platelets; howeve
Publikováno v:
Vox Sanguinis. 116:477-488
Platelets are now acknowledged as key regulators of the immune system, as they are capable of mediating inflammation, leucocyte recruitment and activation. This activity is facilitated through platelet activation, which induces significant changes in
Publikováno v:
Transfusion. 60:2969-2981
BACKGROUND Cryopreservation of platelets with dimethylsulfoxide (DMSO) at -80°C increases their shelf life from days to years. Once thawed, platelets are stored at room temperature (RT), and the shelf life is limited to 4-6 hours. However, refrigera
Autor:
Matthew P. Padula, Robert N. Ben, Denese C. Marks, Jason P. Acker, Lacey Johnson, Lauren Waters
Publikováno v:
Cryobiology. 96:152-158
Improving aspects of platelet cryopreservation would help ease logistical challenges and potentially expand the utility of frozen platelets. Current cryopreservation procedures damage platelets, which may be caused by ice recrystallization. We hypoth