Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice

Autor: Lacek, Krzysztof, Vercauteren, Koen, Grzyb, Katarzyna, Naddeo, Mariarosaria, Verhoye, Lieven, Słowikowski, Marek Patryk, Fafi-Kremer, Samira, Patel, Arvind H., Baumert, Thomas F., Folgori, Antonella, Leroux-Roels, Geert, Cortese, Riccardo, Meuleman, Philip, Nicosia, Alfredo

Publikováno v: In Journal of Hepatology July 2012 57(1):17-23

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Cholesterol conjugation potentiates the antiviral activity of an HIV immunoadhesin

Autor: Urbanowicz, Richard A., Lacek, Krzysztof, Lahm, Armin, Bienkowska-Szewczyk, Krystyna, Ball, Jonathan K., Nicosia, Alfredo, Cortese, Riccardo, Pessi, Antonello

Immunoadhesins are engineered proteins combining the constant domain (Fc) of an antibody with a ligand-binding (adhesion) domain. They have significant potential as therapeutic agents, because they maintain the favourable pharmacokinetics of antibodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::10f182c90de650f5597f2805c726c856
http://hdl.handle.net/11588/746415

Cholesterol conjugation potentiates the antiviral activity of an HIV immunoadhesin.

Autor: Urbanowicz RA; School of Life Sciences, The University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom.; Nottingham Digestive Diseases Centre Biomedical Research Unit, The University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom., Lacek K; CEINGE, Via Gaetano Salvatore 486, 80145, Napoli, Italy.; Laboratory of Virus Molecular Biology, University of Gdansk, 80-822, Gdansk, Poland., Lahm A; PeptiPharma, Viale Città D'Europa 679, 00144, Roma, Italy., Bienkowska-Szewczyk K; Laboratory of Virus Molecular Biology, University of Gdansk, 80-822, Gdansk, Poland., Ball JK; School of Life Sciences, The University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom.; Nottingham Digestive Diseases Centre Biomedical Research Unit, The University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom., Nicosia A; CEINGE, Via Gaetano Salvatore 486, 80145, Napoli, Italy.; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini 5, 80131, Napoli, Italy., Cortese R; CEINGE, Via Gaetano Salvatore 486, 80145, Napoli, Italy., Pessi A; CEINGE, Via Gaetano Salvatore 486, 80145, Napoli, Italy.; PeptiPharma, Viale Città D'Europa 679, 00144, Roma, Italy.; JV Bio, Via Gaetano Salvatore 486, 80145, Napoli, Italy.

Publikováno v: Journal of peptide science : an official publication of the European Peptide Society [J Pept Sci] 2015 Sep; Vol. 21 (9), pp. 743-9.