Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice

Autor: Joseph A. Gogos, Michel Simonneau, Arguello Pa, Richard Blazeski, Liam Drew, Rebecca J. Levy, Heather McKellar, James M. O'Donnell, Lacefield Co, Xiao L, Aude-Marie Lepagnol-Bestel, Mirna Kvajo, Carol A. Mason, Maria Karayiorgou, Amy B. MacDermott

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 108(49)

Carefully designed animal models of genetic risk factors are likely to aid our understanding of the pathogenesis of schizophrenia. Here, we study a mouse strain with a truncating lesion in the endogenous Disc1 ortholog designed to model the effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3ece89544fe5dce8a4dcaa43206a6a
https://pubmed.ncbi.nlm.nih.gov/22049344

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A non-canonical striatopallidal Go pathway that supports motor control.

Autor: Labouesse MA; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA. marie.labouesse@hest.ethz.ch.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA. marie.labouesse@hest.ethz.ch.; Department of Health, Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland. marie.labouesse@hest.ethz.ch.; Neuroscience Center Zurich, ETH Zurich and University of Zurich, 8057, Zurich, Switzerland. marie.labouesse@hest.ethz.ch., Torres-Herraez A; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA., Chohan MO; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA., Villarin JM; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA., Greenwald J; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA., Sun X; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Zahran M; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA.; Barnard College, Columbia University, New York, NY, 10027, USA., Tang A; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA.; Columbia College, Columbia University, New York, NY, 10027, USA., Lam S; Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA., Veenstra-VanderWeele J; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA., Lacefield CO; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA., Bonaventura J; Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA.; Departament de Patologia i Terapèutica Experimental, Institut de Neurociències, L'Hospitalet de Llobregat, Universitat de Barcelona, Barcelona, Spain., Michaelides M; Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA.; Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Chan CS; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Yizhar O; Departments of Brain Sciences and Molecular Neuroscience, Weizmann Institute of Science, Rehovot, 76100, Israel., Kellendonk C; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA. ck491@cumc.columbia.edu.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA. ck491@cumc.columbia.edu.; Department of Molecular Pharmacology & Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA. ck491@cumc.columbia.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Oct 23; Vol. 14 (1), pp. 6712. Date of Electronic Publication: 2023 Oct 23.

Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors.

Autor: Paquelet GE; Department of Neuroscience, Columbia University, New York, NY 10032, USA., Carrion K; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA., Lacefield CO; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA; Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA., Zhou P; Department of Neuroscience, Columbia University, New York, NY 10032, USA; Department of Statistics, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027., Hen R; Department of Neuroscience, Columbia University, New York, NY 10032, USA; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA; Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA., Miller BR; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA; Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: bradley.miller@nyspi.columbia.edu.

Publikováno v: Neuron [Neuron] 2022 Aug 17; Vol. 110 (16), pp. 2664-2679.e8. Date of Electronic Publication: 2022 Jun 13.