Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Labeguere Frederic Gilbert"'
Autor:
Graeme Milligan, Luke Jonathan Alvey, Annick Hagers, Thierry Christophe, Emanuelle Wakselman, Luc Nelles, Line Oste, Steve De Vos, Ann Vandevelde, Katja Conrath, Laurent Saniere, Stephen Robert Fletcher, Laura Jenkins, Sandrine Le Tallec, D. Merciris, Pierre Deprez, Roland Blanque, C. Cottereaux, Romain Luc Marie Gosmini, Ellen van der Aar, Cécile da Costa, Sonia Dupont, Thi Thu Trang Mai, Vanessa Quenehen, Labeguere Frederic Gilbert, Philippe Clément-Lacroix, Florilène Soulas, Reginald Brys, Gregory John Robert Newsome, Nele Vandervoort, Amynata Tirera
Publikováno v:
Journal of Medicinal Chemistry. 63:13526-13545
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8f803bd9662806c89d70fe1a829f85
https://doi.org/10.1021/acs.jmedchem.0c00272
https://doi.org/10.1021/acs.jmedchem.0c00272
Autor:
Romain Luc Marie Gosmini, Graeme Milligan, Laura Jenkins, Irina G. Tikhonova, Zobaer Al Mahmud, Steve De Vos, Brian D. Hudson, Trond Ulven, Labeguere Frederic Gilbert
Publikováno v:
Mahmud, Z A, Jenkins, L, Ulven, T, Labéguère, F, Gosmini, R, De Vos, S, Hudson, B D, Tikhonova, I G & Milligan, G 2017, ' Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 ' Scientific Reports, vol. 7, pp. 17953 . DOI: 10.1038/s41598-017-18159-3
Mahmud, Z A, Jenkins, L, Ulven, T, Labéguère, F, Gosmini, R, De Vos, S, Hudson, B D, Tikhonova, I G & Milligan, G 2017, ' Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 ', Scientific Reports, vol. 7, 17953 . https://doi.org/10.1038/s41598-017-18159-3
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Mahmud, Z A, Jenkins, L, Ulven, T, Labéguère, F, Gosmini, R, De Vos, S, Hudson, B D, Tikhonova, I G & Milligan, G 2017, ' Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 ', Scientific Reports, vol. 7, 17953 . https://doi.org/10.1038/s41598-017-18159-3
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Medium chain fatty acids can activate the pro-inflammatory receptor GPR84 but so also can molecules related to 3,3′-diindolylmethane. 3,3′-Diindolylmethane and decanoic acid acted as strong positive allosteric modulators of the function of each o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6338e603c5ee03dbedb6ae41d34c9d1
https://eprints.gla.ac.uk/153190/1/153190.pdf
https://eprints.gla.ac.uk/153190/1/153190.pdf
