Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Labchan Rajbhandari"'
Autor:
Katherine L. Marshall, Labchan Rajbhandari, Arun Venkatesan, Nicholas J. Maragakis, Mohamed H. Farah
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by degeneration of upper and lower motor neurons that leads to muscle weakness, paralysis, and death, but the effects of disease-causing mutations
Externí odkaz:
https://doaj.org/article/618425bc3da44c26b14ec76b7174e164
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 2, Pp 246-265 (2023)
Abstract Objective Neurodegeneration induced by inflammatory stress in multiple sclerosis (MS) leads to long‐term neurological disabilities that are not amenable to current immunomodulatory therapies. Methods and Results Here, we report that neuron
Externí odkaz:
https://doaj.org/article/f05eec66780d409f8069a0e7586e0935
Autor:
Athanasios S. Alexandris, Jiwon Ryu, Labchan Rajbhandari, Robert Harlan, James McKenney, Yiqing Wang, Susan Aja, David Graham, Arun Venkatesan, Vassilis E. Koliatsos
Publikováno v:
Neurobiology of Disease, Vol 171, Iss , Pp 105808- (2022)
Wallerian degeneration (WD) is a conserved axonal self-destruction program implicated in several neurological diseases. WD is driven by the degradation of the NAD+ synthesizing enzyme NMNAT2, the buildup of its substrate NMN, and the activation of th
Externí odkaz:
https://doaj.org/article/42fcbe21b2bb452a9dc4c15e7bdc5ce2
Autor:
Tomohiko Sadaoka, Daniel P. Depledge, Labchan Rajbhandari, Judith Breuer, Arun Venkatesan, Jeffrey I. Cohen
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Attenuation of the live varicella Oka vaccine (vOka) has been attributed to mutations in the genome acquired during cell culture passage of pOka (parent strain); however, the precise mechanisms of attenuation remain unknown. Comparative sequ
Externí odkaz:
https://doaj.org/article/e7ad591c2f7a4c3b8122f3c04135c600
Autor:
Werner J. D. Ouwendijk, Daniel P. Depledge, Labchan Rajbhandari, Tihana Lenac Rovis, Stipan Jonjic, Judith Breuer, Arun Venkatesan, Georges M. G. M. Verjans, Tomohiko Sadaoka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Varicella-zoster virus (VZV) establishes lifelong neuronal latency in humans. Here, Ouwendijk and Depledge et al. identify a fusion transcript, VLT-ORF63, which is expressed during lytic and latent infection, and demonstrate a role for the translated
Externí odkaz:
https://doaj.org/article/77e9fbb4bab3420d9944cbe543a9206c
Publikováno v:
Annals of Clinical and Translational Neurology. 10:246-265
Neurodegeneration induced by inflammatory stress in multiple sclerosis (MS) leads to long-term neurological disabilities that are not amenable to current immunomodulatory therapies.Here, we report that neuronal downregulation of Splicing factor 3b su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f872a2898a47524ccd73bf1134c5fae
https://doi.org/10.1002/acn3.51717
https://doi.org/10.1002/acn3.51717
Autor:
Itzy E Morales Pantoja, Matthew D Smith, Labchan Rajbhandari, Linzhao Cheng, Yongxing Gao, Vasiliki Mahairaki, Arun Venkatesan, Peter A Calabresi, Kathryn C Fitzgerald, Katharine A Whartenby
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233980 (2020)
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that results in variable severities of neurodegeneration. The understanding of MS has been limited by the inaccessibility of the affected cells a
Externí odkaz:
https://doaj.org/article/575b8464d15d450992578ce877033aa5
Autor:
Ryan E. Tomlinson, Zhi Li, Qian Zhang, Brian C. Goh, Zhu Li, Daniel L.J. Thorek, Labchan Rajbhandari, Thomas M. Brushart, Liliana Minichiello, Fengquan Zhou, Arun Venkatesan, Thomas L. Clemens
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2723-2735 (2016)
Developing tissues dictate the amount and type of innervation they require by secreting neurotrophins, which promote neuronal survival by activating distinct tyrosine kinase receptors. Here, we show that nerve growth factor (NGF) signaling through ne
Externí odkaz:
https://doaj.org/article/98ef489b29e74253b6a9a78c33b2027d
Autor:
Yossef Alnasser, Siva P. Kambhampati, Elizabeth Nance, Labchan Rajbhandari, Shiva Shrestha, Arun Venkatesan, Rangaramanujam M. Kannan, Sujatha Kannan
Publikováno v:
Molecules, Vol 23, Iss 5, p 1025 (2018)
Polyamidoamine (PAMAM) dendrimers are multifunctional nanoparticles with tunable physicochemical features, making them promising candidates for targeted drug delivery in the central nervous system (CNS). Systemically administered dendrimers have been
Externí odkaz:
https://doaj.org/article/84b2d843f0c34a0ba8508d4038c1716f
Autor:
Mir A. Ali, Gabsang Lee, Jeffrey I. Cohen, Abby Mandalla, Labchan Rajbhandari, Hojae Lee, Tomohiko Sadaoka, Balaji Jagdish, Arun Venkatesan, Priya Shukla, Qingxue Li
Publikováno v:
J Virol
Varicella-zoster virus (VZV) maintains lifelong latency in neurons following initial infection and can subsequently be reactivated to result in herpes zoster or severe neurological manifestations such as encephalitis. Mechanisms of VZV neuropathogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9011bfa692617ff9d63711b2cb01292b
https://pubmed.ncbi.nlm.nih.gov/34468169
https://pubmed.ncbi.nlm.nih.gov/34468169