Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors

Autor: Ward, Y. D., Thomson, D. S., Frye, L. L., Cywin, C. L., Morwick, T., Emmanuel, M. J., Zindell, R., McNeil, D., Bekkali, Y., Giradot, M., Hrapchak, M., DeTuri, M., Crane, K., White, D., Pav, S., Wang, Y., Hao, M.-H., Grygon, C. A., Labadia, M. E., Freeman, D. M., Davidson, W., Hopkins, J. L., Brown, M. L., Spero, D. M.

Publikováno v: Journal of Medicinal Chemistry; December 2002, Vol. 45 Issue: 25 p5471-5482, 12p

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Structural and biochemical analysis of signal transduction by the TRAF family of adapter proteins.

Autor: McWhirter SM; Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3206, USA., Pullen SS, Werneburg BG, Labadia ME, Ingraham RH, Crute JJ, Kehry MR, Alber T

Publikováno v: Cold Spring Harbor symposia on quantitative biology [Cold Spring Harb Symp Quant Biol] 1999; Vol. 64, pp. 551-62.

Interaction between the SH2 domains of ZAP-70 and the tyrosine-based activation motif 1 sequence of the zeta subunit of the T-cell receptor.

Autor: Labadia ME; Department of Inflammatory Diseases, Boehringer Ingelheim Pharmaceuticals, Inc., Research and Development Center, Ridgefield, Connecticut 06877-0368, USA., Jakes S, Grygon CA, Greenwood DJ, Schembri-King J, Lukas SM, Warren TC, Ingraham RH

Publikováno v: Archives of biochemistry and biophysics [Arch Biochem Biophys] 1997 Jun 01; Vol. 342 (1), pp. 117-25.

Binding affinities of the SH2 domains of ZAP-70, p56lck and Shc to the zeta chain ITAMs of the T-cell receptor determined by surface plasmon resonance.

Autor: Labadia ME; Department of Immunological Diseases, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, USA., Ingraham RH, Schembri-King J, Morelock MM, Jakes S

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