Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Laan, J.W. van der"'
Autor:
Duijndam, B.H.A., Tedeschi, M., Stel, W. van der, Hoorn, T. van den, Burg, B. van der, Bouwman, R.J.P., Laan, J.W. van der, Water, B. van der
Publikováno v:
Toxicology In Vitro, 81:105348
Estrogen receptor alpha (ERα) is often a primary target of endocrine disrupting chemicals (EDCs) and therefore several biochemical and cell-based assays for the detection of chemicals with estrogenic properties have been developed in the past. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c60e4350ebfa76b16b87a2f0e77a1df
http://hdl.handle.net/1887/3420574
http://hdl.handle.net/1887/3420574
Autor:
Esterik, J. van, Heusinkveld, H., Corvaro, M., Laan, J.W. van der, Lewis, D., Madia, F., Manou, I., Marx-Stoelting, P., Melching-Kollmuss, S., Pasquier, E., Schorsch, F., Steiblen, G., Strupp, C., Wolterink, G., Woutersen, R., Corvi, R., Mehta, J., Luijten, M.
Publikováno v:
In Toxicology Letters 1 September 2022 368 Supplement:S147-S148
Autor:
Braakhuis, H.M., Slob, W., Olthof, E.D., Wolterink, G., Zwart, E.P., Gremmer, E.R., Rorije, E., Benthem, J. van, Woutersen, R., Laan, J.W. van der, Luijten, M.
Publikováno v:
Critical Reviews in Toxicology, 6, 48, 500-511
Non-genotoxic carcinogens (NGTXCs) do not cause direct DNA damage but induce cancer via other mechanisms. In risk assessment of chemicals and pharmaceuticals, carcinogenic risks are determined using carcinogenicity studies in rodents. With the aim to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8cc557633670e895a64b141dd6a2318c
http://resolver.tudelft.nl/uuid:6bfc1dbd-bfa2-47b0-a5e7-48fc7fe1792b
http://resolver.tudelft.nl/uuid:6bfc1dbd-bfa2-47b0-a5e7-48fc7fe1792b
Autor:
Woutersen, R.A., Soffers, A.E.M.F., Kroese, E.D., Krul, C.A.M., Laan, J.W. van der, Benthem, J. van, Luijten, M.
Publikováno v:
Regulatory Toxicology and Pharmacology, 81, 242-249
Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::658a16b47a7f3b858205425709e32961
http://resolver.tudelft.nl/uuid:61ada7d8-1bcc-4046-aa05-855d21c53271
http://resolver.tudelft.nl/uuid:61ada7d8-1bcc-4046-aa05-855d21c53271
Autor:
Dubois, V.F.S.
Publikováno v:
None
QT prolongation and the risk of ventricular arrhythmias in humans remain a major concern during drug development despite the advancement of numerous methodologies to detect the potential for drug-induced changes in cardiac conductivity and the availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::65a37c75e981e6c7a789616cf84e9a65
http://hdl.handle.net/1887/48298
http://hdl.handle.net/1887/48298
Autor:
Braak, S.J. ter
Publikováno v:
None
There is epidemiological evidence that the use of some insulin analogues by diabetic patients is correlated with an increased cancer risk. In vitro exposure experiments revealed that insulin glargine (LANTUS) was the only commercial insulin analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::647d9198814db5d7fb504fa1de8b22ae
https://hdl.handle.net/1887/33222
https://hdl.handle.net/1887/33222