Zobrazeno 1 - 10
of 490
pro vyhledávání: '"Laajala, A. (A.)"'
Autor:
Majid Momeny, Mari Tienhaara, Mukund Sharma, Deepankar Chakroborty, Roosa Varjus, Iina Takala, Joni Merisaari, Artur Padzik, Andreas Vogt, Ilkka Paatero, Klaus Elenius, Teemu D Laajala, Kari J Kurppa, Jukka Westermarck
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1603-1629 (2024)
Abstract Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ breast cancer cells transitioning from dormant drug tole
Externí odkaz:
https://doaj.org/article/709f9a596c0c46e4951cbcebf8781895
Autor:
Mike Mason, Óscar Lapuente-Santana, Anni S. Halkola, Wenyu Wang, Raghvendra Mall, Xu Xiao, Jacob Kaufman, Jingxin Fu, Jacob Pfeil, Jineta Banerjee, Verena Chung, Han Chang, Scott D. Chasalow, Hung Ying Lin, Rongrong Chai, Thomas Yu, Francesca Finotello, Tuomas Mirtti, Mikko I. Mäyränpää, Jie Bao, Emmy W. Verschuren, Eiman I. Ahmed, Michele Ceccarelli, Lance D. Miller, Gianni Monaco, Wouter R. L. Hendrickx, Shimaa Sherif, Lin Yang, Ming Tang, Shengqing Stan Gu, Wubing Zhang, Yi Zhang, Zexian Zeng, Avinash Das Sahu, Yang Liu, Wenxian Yang, Davide Bedognetti, Jing Tang, Federica Eduati, Teemu D. Laajala, William J. Geese, Justin Guinney, Joseph D. Szustakowski, Benjamin G. Vincent, David P. Carbone
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results from the Anti–PD-1 Response Prediction DREAM Challenge, a crowdsourc
Externí odkaz:
https://doaj.org/article/c3635bd5bd234a2da3cffc46f246670f
Autor:
T. Shadbahr, J. Pylväläinen, J. Hoffström, A. Kenttämies, T. Mirtti, T.D. Laajala, A.S. Rannikko
Publikováno v:
European Urology Open Science, Vol 63, Iss , Pp S7-S8 (2024)
Externí odkaz:
https://doaj.org/article/378ebd821e464142aac9434b4c133516
Publikováno v:
European Urology Open Science, Vol 63, Iss , Pp S6- (2024)
Externí odkaz:
https://doaj.org/article/54b9e438607b438c9b4adecc3b62c8c3
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background:Prostate cancer is a leading cause of cancer-related deaths among men, marked by heterogeneous clinical and molecular characteristics. The complexity of the molecular landscape necessitates tools for identifying multi-gene co-alteration pa
Externí odkaz:
https://doaj.org/article/3c48b08ff4464bb3acbf192fcd5deb5b
Autor:
Anne Laajala, Matti Nuutinen, Atso Luttinen, Hannu Vähänikkilä, Tarja Tanner, Marja-Liisa Laitala, Saujanya Karki
Publikováno v:
Acta Odontologica Scandinavica, Vol 83, Iss 1 (2024)
Objective: The aim of this study was to explore the factors associated with the survival of root canal treated teeth in a practise-based study setting in a 5-year period. Material and methods: This retrospective study used data from the electronic
Externí odkaz:
https://doaj.org/article/fc2e88b3cc9046d9a4a8141b500636a7
Autor:
Teemu D. Laajala, Varsha Sreekanth, Alex C. Soupir, Jordan H. Creed, Anni S. Halkola, Federico C. F. Calboli, Kalaimathy Singaravelu, Michael V. Orman, Christelle Colin-Leitzinger, Travis Gerke, Brooke L. Fridley, Svitlana Tyekucheva, James C. Costello
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Genomic and transcriptomic data have been generated across a wide range of prostate cancer (PCa) study cohorts. These data can be used to better characterize the molecular features associated with clinical outcomes and to test hypotheses acr
Externí odkaz:
https://doaj.org/article/74d7b11469474de8bb6ff94431c8476f
Autor:
Lassi Luomala, Kalle Mattila, Paula Vainio, Harry Nisén, Teijo Pellinen, Jouni Lohi, Teemu D. Laajala, Petrus Järvinen, Anna‐Riina Koskenniemi, Panu Jaakkola, Tuomas Mirtti
Publikováno v:
Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract Background Hypoxia inducible factors, HIF‐1α and HIF‐2α, and their main regulators, the prolyl hydroxylase domain proteins (PHDs), mediate cellular response to hypoxia and contribute to tumor progression in clear cell renal cell carcin
Externí odkaz:
https://doaj.org/article/c03724c045a9453491bfbda1ba93dc88
Autor:
Sailee Shroff, Marjo Haapakoski, Kosti Tapio, Mira Laajala, Miika Leppänen, Zlatka Plavec, Antti Haapala, Sarah J. Butcher, Janne A. Ihalainen, J. Jussi Toppari, Varpu Marjomäki
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTViruses may persist on solid surfaces for long periods, which may contribute to indirect transmission. Thus, it is imperative to develop functionalized surfaces that will lower the infectious viral load in everyday life. Here, we have tested
Externí odkaz:
https://doaj.org/article/08bcc539b9a944d6995c24aa17b16c57
Autor:
Marjo Haapakoski, Aleksei Emelianov, Dhanik Reshamwala, Mira Laajala, Jenni Tienaho, Petri Kilpeläinen, Jaana Liimatainen, Tuula Jyske, Mika Pettersson, Varpu Marjomäki
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Due to seasonally appearing viruses and several outbreaks and present pandemic, we are surrounded by viruses in our everyday life. In order to reduce viral transmission, functionalized surfaces that inactivate viruses are in large demand. Here the en
Externí odkaz:
https://doaj.org/article/5f2c66cc7893489b9f413c208b06256f