Mps1 expression is critical for chromosome orientation and segregation in yeast with high ploidy

Autor: Gish M, Sartin A, LaVictoire R, Régis E. Meyer, Haworth D, Harsha J

In aneuploid cancer cells, the chromosome segregation apparatus is sensitive to increased chromosome number. The conserved protein kinase, Mps1, is a critical actor of this machinery, orienting the chromosomes properly on the spindle. Abnormally high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762fa03dc55b38d188d80b26ac1ff535
https://doi.org/10.1101/2020.03.26.006387

Polyploid yeast are dependent on elevated levels of Mps1 for successful chromosome segregation.

Autor: Meyer RE; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America., Sartin A; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America., Gish M; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America., Harsha J; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America., Wilkie E; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America., Haworth D; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America., LaVictoire R; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America., Alberola I; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America., Chuong HH; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America., Gorbsky GJ; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America., Dawson DS; Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, United States of America.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 10. Date of Electronic Publication: 2023 Jan 10.