Zobrazeno 1 - 10
of 22
pro vyhledávání: '"LaToya S. Jones"'
Autor:
Samadhi N. Vitharana, LaToya S. Jones, C. Russell Middaugh, Ambarish Shah, Melissa D. Perkins, Adeola O. Grillo, Thomas Spitznagel, Tiffany Derrick, Jason Rexroad
Publikováno v:
Journal of Pharmaceutical Sciences. 96:761-776
The interaction of several of the fibroblast growth factors (FGFs) with polyanions is thought to be of physiological significance and has been exploited to create more stable pharmaceutical formulations of FGF-1 and -2. The extent of such phenomena t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf331e3c0936fbdf3f8c359c9b30df1e
https://doi.org/10.1002/jps.20797
https://doi.org/10.1002/jps.20797
Publikováno v:
Analytical Biochemistry. 351:282-289
Comparative studies of the secondary structures of six model proteins, adsorbed onto aluminum hydroxide gel (Alhydrogel) or in aqueous solution, were carried out by Fourier transform infrared (FTIR) spectroscopy. The analysis of high-quality spectra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc4bc8c7a66ee4145554441057e17f0
https://doi.org/10.1016/j.ab.2006.01.008
https://doi.org/10.1016/j.ab.2006.01.008
Publikováno v:
Journal of Pharmaceutical Sciences. 94:918-927
Prior to delivery to the patient, protein pharmaceuticals often come in contact with a variety of surfaces (e.g., syringes and stoppers), which are treated to facilitate processing or to inhibit protein binding. One such coating, silicone oil, has pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e557cd8a4bc9f1e61c5e02a246da7fc
https://doi.org/10.1002/jps.20321
https://doi.org/10.1002/jps.20321
Autor:
Duane T. Brandau, Jason Rexroad, LaToya S. Jones, C. Russell Middaugh, Christopher M. Wiethoff
Publikováno v:
Journal of Pharmaceutical Sciences. 92:218-231
Worldwide vaccination programs against infectious diseases and toxins are estimated to save approximately 3 million lives yearly. Tragically, however, another 3 million individuals (primarily children) die of vaccine-preventable diseases. A significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cfebe1666560464452344c71718141
https://doi.org/10.1002/jps.10296
https://doi.org/10.1002/jps.10296
Publikováno v:
Cell Preservation Technology. 1:91-104
Currently, vaccines are developed as either lyophilized or aqueous formulations; however, the inherent lack of vaccine thermostability requires storage at subambient temperatures. In the developing world, meeting these storage requirements can be dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77b67dfa5913706039acb5710968bd95
https://doi.org/10.1089/153834402320882593
https://doi.org/10.1089/153834402320882593
Autor:
Gerhard Winter, Mark C. Manning, John F. Carpenter, Marie-Luise Hagmann, Theodore W. Randolph, Ulrich Kohnert, Apollon Papadimitriou, LaToya S. Jones
Publikováno v:
Journal of Pharmaceutical Sciences. 90:1466-1477
We have chosen an anti-L-selectin antibody as a model protein to investigate the effects of sucrose and/or Tween 20 on protein stability during lyophilization and reconstitution. Native anti-L-selectin secondary structure is substantially retained du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d0254c3f2f0349cdc990991d5a1932
https://doi.org/10.1002/jps.1098
https://doi.org/10.1002/jps.1098
Autor:
Jeffrey D. Meyer, Xanthe M. Lam, LaToya S. Jones, Jeffrey L. Cleland, Tzung‐Horng Yang, Mark C. Manning, John F. Carpenter, Theodore W. Randolph
Publikováno v:
Journal of Pharmaceutical Sciences. 89:1480-1485
Metal-induced precipitation of protein therapeutics is being used and further developed as a processing step in protein formulation and may have utility in protein purification and bulk storage. In such processes, it is imperative that native protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::341366d566a675aedc44c6e7078c3cbe
https://doi.org/10.1002/1520-6017(200011)89:11<1480::aid-jps10>3.0.co
https://doi.org/10.1002/1520-6017(200011)89:11<1480::aid-jps10>3.0.co
Autor:
John F. Carpenter, Sven Frokjaer, Lotte Kreilgaard, Theodore W. Randolph, LaToya S. Jones, James M. Flink, Mark C. Manning
Publikováno v:
Journal of Pharmaceutical Sciences. 87:1597-1603
Agitation- and freeze-thawing-induced aggregation of recombinant human factor XIII (rFXIII) is due to interfacial adsorption and denaturation at the air-liquid and ice-liquid interfaces. The aggregation pathway proceeds through soluble aggregates to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b7ed04f6e8d39997bb55b89bcc29d8
https://doi.org/10.1021/js980126i
https://doi.org/10.1021/js980126i
Publikováno v:
Vaccine. 24(31-32)
Region II of the erythrocyte-binding antigen (EBA-175 RII) has been identified as a promising target for a malaria vaccine. A systematic approach to identify optimal preformulation conditions of a non-glycosylated (NG) antigen, EBA-175 RII-NG, has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70292566ba53ae843297ba00fb7fe4e7
https://pubmed.ncbi.nlm.nih.gov/16735084
https://pubmed.ncbi.nlm.nih.gov/16735084
Autor:
Aaron P. Markham, C. Russell Middaugh, Jonathan D. Power, Laura J. Peek, Brian Yazzie, LaToya S. Jones
Publikováno v:
The Journal of biological chemistry. 280(14)
The effect of adsorption onto aluminum salt adjuvants on the structure and stability of three model protein antigens was studied using fluorescence and Fourier transform infrared spectroscopies, as well as isothermal titration and differential scanni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68029cc7b41b2dbabcab4c095bc656a3
https://pubmed.ncbi.nlm.nih.gov/15684430
https://pubmed.ncbi.nlm.nih.gov/15684430