Zobrazeno 1 - 10
of 33
pro vyhledávání: '"LaRonda L Morford"'
Autor:
Vincent L. Reynolds, Wei Wang, Meredith A. Steeves, Javed A. Bhalli, LaRonda L Morford, Matthew M. Abernathy, Ronee B. Baracani
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Autor:
LaRonda L. Morford, Meredith Rocca, Wendy G. Halpern, Diann Blanset, Joy A. Cavagnaro, Christopher J. Bowman
Publikováno v:
Regulatory Toxicology and Pharmacology. 98:69-79
Toxicity studies in pregnant animals are not always necessary for assessing the human risk of developmental toxicity of biopharmaceuticals. The growing experience and information on target biology and molecule-specific pharmacokinetics present a powe
Publikováno v:
International Journal of Toxicology. 35:499-520
The study of developmental neurotoxicity (DNT) continues to be an important component of safety evaluation of candidate therapeutic agents and of industrial and environmental chemicals. Developmental neurotoxicity is considered to be an adverse chang
Autor:
Sandra L. Wood, Stephanie L. Rock, Michael T. Williams, Charles V. Vorhees, Tracy M. Reed, Carrie A. Brown, LaRonda L Morford, Masao Fukumura, Matthew R. Skelton, Anne E McCrea
Publikováno v:
Neurotoxicology and Teratology. 27:117-134
We have previously shown that P11-20 treatment with d-methamphetamine (MA) induces impaired spatial navigation in the Morris water maze (MWM), whereas P1-10 treatment does not. Little is known about the long-term behavioral consequences of MA during
Publikováno v:
Environmental Health Perspectives
Children differ from adults both physiologically and behaviorally. These differences can affect how and when exposures to xenobiotics occur and the resulting responses. Testing using animal models may be used to predict whether children display novel
Autor:
Gary A. Gudelsky, Michael T. Williams, LaRonda L Morford, Sandra L. Inman-Wood, Charles V. Vorhees
Publikováno v:
European Journal of Neuroscience. 16:491-500
d-Fenfluramine, a serotonin releaser, was administered to neonatal rats on postnatal days 11–20 (a stage of hippocampal development analogous to third trimester human ontogeny). As adults, the d-fenfluramine-treated offspring exhibited dose-related
Autor:
Stephanie L. Rock, Mary S. Moran, Michael T. Williams, Amie M Ruttle, Charles V. Vorhees, Sandra L. Inman-Wood, LaRonda L Morford, Anne E McCrea
Publikováno v:
Neurotoxicology and Teratology. 22:751-759
Treatment with methamphetamine (MA) on postnatal days P11–20 induces adult spatial learning and memory deficits without affecting monoamine levels in various brain regions. In this study, we examined the pituitary and adrenal response of animals ad
Autor:
Masao Fukumura, LaRonda L Morford, Harry W. Broening, Mary S. Moran, Sandra L. Inman-Wood, Charles V. Vorhees
Publikováno v:
The Journal of Neuroscience. 20:4732-4739
The effects of neonatald-methamphetamine (MA) treatment on cued and spatial learning and memory were investigated. MA was administered to neonatal rats on postnatal days 11–20. All groups received four subcutaneous injections per day. Group MA40–
Autor:
Tracy M. Reed, Sandra L. Inman-Wood, Gregg D Cappon, LaRonda L Morford, Cunfeng Pu, Charles V. Vorhees, Mary S. Moran
Publikováno v:
Neurotoxicology and Teratology. 22:255-265
Prenatal cocaine treatment produces equivocal effects on spatial learning and memory; however, no data are available on neonatal treatment as a model of human third-trimester exposure. Sprague-Dawley rats were treated on postnatal days (P) 1-10 or 11
Publikováno v:
Neurotoxicology and Teratology. 21:567-578
Previous research has shown that rats exposed to phenytoin (PHT) in utero demonstrate abnormal circling, decreased learning, hyperactivity, and delayed air righting reflex development. The effects of prenatal PHT on offspring learning have been found