Výsledky vyhledávání - "LaRocque, J. R."

Akademický článek

Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair.

Autor: Wensveen MR; Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, the Netherlands., Dixit AA; Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, the Netherlands., van Schendel R; Human Genetics Department, Leiden University Medical Center, Leiden, the Netherlands., Kendek A; Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, the Netherlands., Lambooij JP; Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, the Netherlands., Tijsterman M; Human Genetics Department, Leiden University Medical Center, Leiden, the Netherlands., Colmenares SU; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, USA., Janssen A; Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, the Netherlands. a.janssen-2@umcutrecht.nl.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 17; Vol. 15 (1), pp. 8984. Date of Electronic Publication: 2024 Oct 17.

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Reducing DNA Polymerase in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects

Autor: Hussain, S. K., Sekelsky, J., LaRocque, J. R., Dougherty, D. L.

The ability to respond to DNA damage and incomplete replication ensures proper duplication and stability of the genome. Two checkpoint kinases, ATM and ATR, are required for DNA damage and replication checkpoint responses. In Drosophila, the ATR orth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40da3fe79958ce25a6710e5c5995a94d

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Drosophila ATR in Double-Strand Break Repair

Autor: LaRocque, J. R., Sekelsky, J., Jaklevic, B., Su, T. T.

The ability of a cell to sense and respond to DNA damage is essential for genome stability. An important aspect of the response is arrest of the cell cycle, presumably to allow time for repair. Ataxia telangiectasia mutated (ATM) and ATR are essentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2d2a0faf41bc79d243fe47855c3088d

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Akademický článek

OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress.

Autor: Villa S; Quantitative and Systems Biology, University of California, Merced, CA, 95343, USA.; Calico Life Sciences, 1170 Veterans Boulevard, South San Francisco, CA, 94080, USA., Dwivedi P; Department of Microchemistry, Proteomics, and Lipidomics, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.; Merck, West Point, PA, 19486, USA., Stahl A; Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, 52242, USA.; Department of Neuroscience, Scripps Research, Jupiter, FL, 33458, USA., Hinkle T; Department of Microchemistry, Proteomics, and Lipidomics, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA., Rose CM; Department of Microchemistry, Proteomics, and Lipidomics, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA., Kirkpatrick DS; Department of Microchemistry, Proteomics, and Lipidomics, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.; Xaira Therapeutics, Brisbane, CA, 94005, USA., Tomchik SM; Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, 52242, USA.; Department of Neuroscience, Scripps Research, Jupiter, FL, 33458, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, 52242, USA.; Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA, 52242, USA., Dixit VM; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Wolf FW; Quantitative and Systems Biology, University of California, Merced, CA, 95343, USA. fwolf@ucmerced.edu.; Department of Molecular and Cell Biology, University of California, Merced, CA, 95343, USA. fwolf@ucmerced.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 11; Vol. 15 (1), pp. 6873. Date of Electronic Publication: 2024 Aug 11.

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Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion

Autor: Adams, M. D., McVey, M., Sekelsky, J. J., LaRocque, J. R.

Bloom syndrome is a rare disorder associated with cancer predisposition and genomic instability and is caused by loss of the RecQ helicase BLM. The Drosophila ortholog of BLM (DmBlm) is required for accurate repair of DNA double-strand gaps by homolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93ec8551db52c755ff3ab86a2872211e

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Akademický článek

Upregulation of NDUFAF2 in Lung Adenocarcinoma Is a Novel Independent Prognostic Biomarker.

Autor: Zou, Kang^1,2 (AUTHOR), Gao, Pengxiang³ (AUTHOR), Xu, Xinping^4,5 (AUTHOR), Zhang, Wei^3,4,5 (AUTHOR), Zeng, Zhenguo¹ (AUTHOR)

Publikováno v: Computational & Mathematical Methods in Medicine. 1/17/2023, p1-20. 20p.

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