Zobrazeno 1 - 10
of 14
pro vyhledávání: '"LaKeisha Perkins"'
Autor:
Quy Le, Brandon Hadland, Jenny L. Smith, Amanda Leonti, Benjamin J. Huang, Rhonda Ries, Tiffany A. Hylkema, Sommer Castro, Thao T. Tang, Cyd N. McKay, LaKeisha Perkins, Laura Pardo, Jay Sarthy, Amy K. Beckman, Robin Williams, Rhonda Idemmili, Scott Furlan, Takashi Ishida, Lindsey Call, Shivani Srivastava, Anisha M. Loeb, Filippo Milano, Suzan Imren, Shelli M. Morris, Fiona Pakiam, Jim M. Olson, Michael R. Loken, Lisa Brodersen, Stanley R. Riddell, Katherine Tarlock, Irwin D. Bernstein, Keith R. Loeb, Soheil Meshinchi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
The CBFA2T3-GLIS2 (C/G) fusion is a product of a cryptic translocation primarily seen in infants and early childhood and is associated with dismal outcome. Here, we demonstrate that the expression of the C/G oncogenic fusion protein promotes the tran
Externí odkaz:
https://doaj.org/article/134ccd270d5242848fcfcd4f706249e4
Autor:
Quy Le, Thao Tang, Amanda Leonti, Sommer Castro, Cyd Nourigat McKay, LaKeisha Perkins, Laura Pardo, Danielle Kirkey, Tiffany Hylkema, Lindsey Call, Makia Manselle, Cristina Abrahams, Kristin Bedard, Arturo Molina, Lisa Eidenshinck Brodersen, Michael R. Loken, Katherine Tarlock, Soheil Meshinchi, Keith R. Loeb
Publikováno v:
Blood Advances. 7:1666-1670
Autor:
Danielle C. Kirkey, Anisha M. Loeb, Sommer Castro, Cyd Nourigat McKay, LaKeisha Perkins, Laura Pardo, Amanda R. Leonti, Thao T. Tang, Michael R. Loken, Lisa Eidenschink Brodersen, Keith R. Loeb, David A. Scheinberg, Quy Le, Soheil Meshinchi
Publikováno v:
Blood Advances. 7:1178-1189
Preferentially Expressed Antigen in Melanoma (PRAME), a cancer-testis antigen, provides an ideal target for immunotherapy in acute myeloid leukemia (AML). We have shown expression of PRAME in a significant subset of childhood and adult AML and lack o
Targeting FOLR1 in high-risk CBF2AT3-GLIS2 pediatric AML with STRO-002 FOLR1–antibody-drug conjugate
Autor:
Thao Tang, Quy Le, Sommer Castro, Laura Pardo, Cyd Nourigat McKay, LaKeisha Perkins, Jenny Smith, Danielle Kirkey, Cristina Abrahams, Kristin Bedard, Arturo Molina, Lisa Eidenshinck Brodersen, Michael R. Loken, Katherine Tarlock, Soheil Meshinchi, Keith R. Loeb
Publikováno v:
Blood Advances. 6:5933-5937
Therapeutic Targeting of Mesothelin with Chimeric Antigen Receptor T Cells in Acute Myeloid Leukemia
Autor:
Katherine Tarlock, Salvatore Fiorenza, Soheil Meshinchi, Lindsey F Call, Quy Le, Cameron J. Turtle, Anisha M Loeb, Cyd Nourigat McKay, Jenny L. Smith, Michael R. Loken, Shivani Srivastava, LaKeisha Perkins, Rhonda E. Ries, Stanley R. Riddell, Amanda R. Leonti, Colin Correnti, Laura Pardo, Thao T. Tang, Tiffany A. Hylkema, Sommer Castro
Publikováno v:
Clinical Cancer Research. 27:5718-5730
Purpose: We previously identified mesothelin (MSLN) as highly expressed in a significant fraction of acute myeloid leukemia (AML) but entirely silent in normal hematopoiesis, providing a promising antigen for immunotherapeutic targeting that avoids h
Autor:
Jay F. Sarthy, Suzan Imren, Brandon Hadland, Soheil Meshinchi, Sommer Castro, Keith R. Loeb, Benjamin J. Huang, Cynthia Nourigat, Scott N. Furlan, LaKeisha Perkins, Shivani Srivastava, Rhonda E. Ries, Thao T Tang, Irwin D. Bernstein, Jenny L. Smith, Lisa Eidenschink Brodersen, Katherine Tarlock, Stanley R. Riddell, Larua Pardo, Lindsey F Call, Amy Beckman, Rhonda Idemmili, Amanda R. Leonti, Tiffany A. Hylkema, Takashi Ishida, Anisha M Loeb, Quy Le, Loken Michael, Robin Williams
Fusion oncoproteins are the initiating event in AML pathogenesis, although they are thought to require additional cooperating mutations for leukemic transformation. CBFA2T3-GLIS2 (C/G) fusion occurs exclusively in infants and is associated with highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::006f550daf8c2558a104753f1a38f789
https://doi.org/10.21203/rs.3.rs-757279/v1
https://doi.org/10.21203/rs.3.rs-757279/v1
Autor:
Quy Le, LaKeisha Perkins, Laura Pardo, Cynthia Nourigat-Mckay, Soheil Meshinchi, Amanda R. Leonti, Lindsey F Call, Thao T. Tang, Sommer Castro
Publikováno v:
Blood. 138:1712-1712
Effective immunotherapy for acute myeloid leukemia (AML) has been limited by the lack of AML-restricted targets (expression in AML but silent in normal hematopoiesis). Current immunotherapies targeting lineage markers CD33 and CD123 (if effective) wo
Autor:
Amanda R. Leonti, Cynthia Nourigat-Mckay, Rhonda E. Ries, Tiffany A. Hylkema, Sommer Castro, Michael R. Loken, LaKeisha Perkins, Thao T. Tang, Soheil Meshinchi, Lisa Eidenschink Brodersen, Jenny L. Smith, Laura Pardo, Keith R. Loeb, Quy Le
Publikováno v:
Blood. 138:360-360
The CBFA2T3-GLIS2 (CBF/GLIS) fusion is a product of a cryptic translocation exclusively seen in refractory infant AML. Lack of relevant model systems that accurately recapitulate this infant AML has limited progress. To overcome this barrier, we deve
Autor:
Cynthia Nourigat-Mckay, Sommer Castro, Soheil Meshinchi, Amanda R. Leonti, Lindsey F Call, Laura Pardo, Thao T. Tang, Quy Le, LaKeisha Perkins
Publikováno v:
Blood. 138:2789-2789
Adoptive transfer of T cells engineered to express chimeric antigen receptors (CARs) has achieved impressive outcomes in the treatment of refractory/relapsed B-ALL, providing potentially curative treatment options for these patients. The use of CAR T
Autor:
Thao T. Tang, Tiffany A. Hylkema, Anisha M Loeb, Cynthia Nourigat-Mckay, Laura Pardo, Amanda R. Leonti, Soheil Meshinchi, Quy Le, LaKeisha Perkins, Sommer Castro, Lindsey F Call, David A. Scheinberg
Publikováno v:
Blood. 138:733-733
Chimeric antigen receptor (CAR) Ts have been effective in pre-B ALL, but their efficacy in AML has yet to be established. A significant barrier to effective CAR T therapy for AML is the substantial overlap of cell surface antigens expressed on AML an