Zobrazeno 1 - 10
of 136
pro vyhledávání: '"LaDora V Thompson"'
Autor:
Amber J Normann, Clifton C Mo, Rebekah L Wilson, Michelle Perez, Corey Cutler, Hajime Uno, LaDora V Thompson, Tina L Skinner, Paul G Richardson, Catherine R Marinac, Christina M Dieli-Conwright
Publikováno v:
JMIR Research Protocols, Vol 13, p e64905 (2024)
BackgroundMuscle mass and strength are severely compromised in patients diagnosed with multiple myeloma, such that the risk of poor overall survival increases as the prevalence of low muscle mass, also known as sarcopenia, increases. Additionally, at
Externí odkaz:
https://doaj.org/article/f72cfbbe0fc149ab9a3a21c8f9a4f789
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214982 (2019)
Disuse induces adaptations in skeletal muscle, which lead to muscle deterioration. Hindlimb-unloading (HU) is a well-established model to investigate cellular mechanisms responsible for disuse-induced skeletal muscle dysfunction. In myosin heavy chai
Externí odkaz:
https://doaj.org/article/8d56d5559eed4ea2934d05fd98982b29
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166831 (2016)
The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome. While its function has been linked to conditions of atrophy, its c
Externí odkaz:
https://doaj.org/article/90d9402184c947ac80afca4b80b79d26
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160839 (2016)
It is well known that the ubiquitin-proteasome system is activated in response to skeletal muscle wasting and functions to degrade contractile proteins. The loss of these proteins inevitably reduces skeletal muscle size (i.e., quantity). However, it
Externí odkaz:
https://doaj.org/article/0ee356e11f3242599e4d12a807a0b184
Publikováno v:
Topics in Geriatric Rehabilitation. 39:88-99
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca647aa91a28119ee37b0428402a429
https://doi.org/10.1097/tgr.0000000000000389
https://doi.org/10.1097/tgr.0000000000000389
Autor:
Laís R. Perazza, Adam C. Gower, Holly M. Brown-Borg, Paola Divieti Pajevic, LaDora V. Thompson
Publikováno v:
GeroScience.
Frailty in aging is driven by the dysregulation of multiple biological pathways. Protectin DX (PDX) is a docosahexaenoic acid (DHA)-derived molecule that alleviates many chronic inflammatory disorders, but its potential effects on frailty remain unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7acc55025fa502984d55fbf9e66d6126
https://doi.org/10.1007/s11357-023-00789-3
https://doi.org/10.1007/s11357-023-00789-3
Autor:
LaDora V. Thompson, Dongmin Kwak
Publikováno v:
Sports Medicine and Health Science, Vol 3, Iss 1, Pp 1-10 (2021)
The prevalence of frailty across the world in older adults is increasing dramatically and having frailty places a person at increased risk for many adverse health outcomes, including impaired mobility, falls, hospitalizations, and mortality. Globally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b48f5a54d78857276ca4ac965415ca
https://doi.org/10.1016/j.smhs.2020.11.005
https://doi.org/10.1016/j.smhs.2020.11.005
Publikováno v:
Compr Physiol
Frailty is a complex syndrome affecting a growing sector of the global population as medical developments have advanced human mortality rates across the world. Our current understanding of frailty is derived from studies conducted in the laboratory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5751a480baab5eab1a873f258a63e25a
https://europepmc.org/articles/PMC9531553/
https://europepmc.org/articles/PMC9531553/
Publikováno v:
Physiology (Bethesda)
The underlying mechanisms contributing to the onset of frailty, its progression, and its mortality risk remain unknown. Recently, the two most common human frailty assessments were reverse-translated to mice. Here, we highlight the development of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b057a47253c30cb9ed9348d2eb4c72
https://doi.org/10.1152/physiol.00016.2020
https://doi.org/10.1152/physiol.00016.2020
Publikováno v:
Aging (Albany NY)
Many age-related biochemical, physiological and behavioral changes are known to be sex-specific. However, how sex influences frailty status and mortality risk in frail rodents has yet to be established. The purpose of this study was therefore to char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40af97b1f6b66ba2951019a21be8836b
https://doi.org/10.18632/aging.102114
https://doi.org/10.18632/aging.102114