Intrinsic catalytic properties of histone H3 lysine-9 methyltransferases preserve monomethylation levels under low S-adenosylmethionine.

Autor: Haws SA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Biomolecular Chemistry, SMPH, University of Wisconsin-Madison, Madison, Wisconsin, USA., Miller LJ; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Biomolecular Chemistry, SMPH, University of Wisconsin-Madison, Madison, Wisconsin, USA., La Luz DR; Department of Mathematics, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kuznetsov VI; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Biomolecular Chemistry, SMPH, University of Wisconsin-Madison, Madison, Wisconsin, USA., Trievel RC; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Craciun G; Department of Biomolecular Chemistry, SMPH, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Mathematics, University of Wisconsin-Madison, Madison, Wisconsin, USA., Denu JM; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Biomolecular Chemistry, SMPH, University of Wisconsin-Madison, Madison, Wisconsin, USA. Electronic address: john.denu@wisc.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Jul; Vol. 299 (7), pp. 104938. Date of Electronic Publication: 2023 Jun 17.