Caffeic Acid Phenethyl Ester (CAPE) Protects PC12 Cells from Cisplatin-Induced Neurotoxicity by Activating the NGF-Signaling Pathway

Autor: Laís Silva Fernandes, Nádia Maria Martins, Antonio Cardozo dos Santos, Neife Aparecida Guinaim dos Santos, Rafaela Scalco Ferreira

Publikováno v: Neurotoxicity Research. 34:32-46

Cisplatin is a highly effective chemotherapeutic drug that is toxic to the peripheral nervous system. Findings suggest that axons are early targets of the neurotoxicity of cisplatin. Although many compounds have been reported as neuroprotective, ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157a4b270e7f902aaa4a58f4c25e35be
https://doi.org/10.1007/s12640-017-9849-z

The Antidiabetic Drug Liraglutide Minimizes the Non-Cholinergic Neurotoxicity of the Pesticide Mipafox in SH-SY5Y Cells

Autor: Laís Silva Fernandes, Guilherme Luz Emerick, Neife Aparecida Guinaim dos Santos, Antonio Cardozo dos Santos

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Organophosphorus (OPs) compounds have been widely used in agriculture, industry, and household, and the neurotoxicity induced by them is still a cause of concern. The main toxic mechanism of OPs is the inhibition of acetylcholinesterase (AChE); howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4bc86f54424c839fb4baa5576abf25
https://pubmed.ncbi.nlm.nih.gov/30088187

In vitro study of the neuropathic potential of the organophosphorus compounds fenamiphos and profenofos: Comparison with mipafox and paraoxon

Autor: Guilherme Luz Emerick, Fernando Barbosa, Antonio Cardozo dos Santos, Eloisa Silva de Paula, Neife Aparecida Guinaim dos Santos, Laís Silva Fernandes

Publikováno v: Toxicology in Vitro. 29:1079-1087

Organophosphorus-induced delayed neuropathy (OPIDN) is a central-peripheral distal axonopathy that develops 8-14 days after poisoning by a neuropathic organophosphorus compound (OP). Several OPs that caused OPIDN were withdrawn from the agricultural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de834d65a509762aeaad0ba37874f518
https://doi.org/10.1016/j.tiv.2015.04.009

High concentration of trichlorfon (1mM) disrupts axonal cytoskeleton and decreases the expression of plasticity-related proteins in SH-SY5Y cells

Autor: Antonio Cardozo dos Santos, Rafaela Scalco Ferreira, Laís Silva Fernandes, Neife Aparecida Guinaim dos Santos, Guilherme Luz Emerick

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 39

Some organophosphorus compounds (OPs) induce a neurodegenerative disorder known as organophosphate-induced delayed neuropathy (OPIDN), which is related to irreversible inhibition of neuropathy target esterase (NTE) and impairment of neurite outgrowth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d4a05c7332cf16b49a5ffd64a03d0a
https://pubmed.ncbi.nlm.nih.gov/27939611

In vitro study of the neuropathic potential of the organophosphorus compounds trichlorfon and acephate

Autor: Guilherme Luz Emerick, Eloisa Silva de Paula, Neife Aparecida Guinaim dos Santos, Fernando Barbosa, Antonio Cardozo dos Santos, Laís Silva Fernandes

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 29(3)

Organophosphorus-induced delayed neuropathy (OPIDN) is a central and peripheral distal axonopathy characterized by ataxia and paralysis. Trichlorfon and acephate are two organophosphorus compounds (OPs) used worldwide as insecticide and which cause s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f186c2e53a3f0a9e1be4c0c280f7127
https://pubmed.ncbi.nlm.nih.gov/25596135