SARS-CoV-2 uses CD4 to infect T helper lymphocytes

Autor: Natalia S Brunetti, Gustavo G Davanzo, Diogo de Moraes, Allan JR Ferrari, Gabriela F Souza, Stéfanie Primon Muraro, Thiago L Knittel, Vinicius O Boldrini, Lauar B Monteiro, João Victor Virgílio-da-Silva, Gerson S Profeta, Natália S Wassano, Luana Nunes Santos, Victor C Carregari, Artur HS Dias, Flavio P Veras, Lucas A Tavares, Julia Forato, Icaro MS Castro, Lícia C Silva-Costa, André C Palma, Eli Mansour, Raisa G Ulaf, Ana F Bernardes, Thyago A Nunes, Luciana C Ribeiro, Marcus V Agrela, Maria Luiza Moretti, Lucas I Buscaratti, Fernanda Crunfli, Raissa G Ludwig, Jaqueline A Gerhardt, Natália Munhoz-Alves, Ana Maria Marques, Renata Sesti-Costa, Mariene R Amorim, Daniel A Toledo-Teixeira, Pierina Lorencini Parise, Matheus Cavalheiro Martini, Karina Bispos-dos-Santos, Camila L Simeoni, Fabiana Granja, Virgínia C Silvestrini, Eduardo B de Oliveira, Vitor M Faca, Murilo Carvalho, Bianca G Castelucci, Alexandre B Pereira, Laís D Coimbra, Marieli MG Dias, Patricia B Rodrigues, Arilson Bernardo SP Gomes, Fabricio B Pereira, Leonilda MB Santos, Louis-Marie Bloyet, Spencer Stumpf, Marjorie C Pontelli, Sean Whelan, Andrei C Sposito, Robson F Carvalho, André S Vieira, Marco AR Vinolo, André Damasio, Licio Velloso, Ana Carolina M Figueira, Luis LP da Silva, Thiago Mattar Cunha, Helder I Nakaya, Henrique Marques-Souza, Rafael E Marques, Daniel Martins-de-Souza, Munir S Skaf, Jose Luiz Proenca-Modena, Pedro MM Moraes-Vieira, Marcelo A Mori, Alessandro S Farias

Publikováno v: eLife, Vol 12 (2023)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related c

Externí odkaz: https://doaj.org/article/99a35dd8fb984baea7fc8271d68472e7

Identification of Compounds With Antiviral Activity Against SARS-CoV-2 in the MMV Pathogen Box Using a Phenotypic High-Throughput Screening Assay

Autor: Laís D. Coimbra, Alexandre Borin, Marina Fontoura, Humberto D. Gravina, Alice Nagai, Jacqueline Farinha Shimizu, Karina Bispo-dos-Santos, Fabiana Granja, Paulo S. L. Oliveira, Kleber G. Franchini, Kirandeep Samby, Marjorie Bruder, José Luiz Proença-Módena, Daniela B. B. Trivella, Juliana H. C. Smetana, Artur T. Cordeiro, Rafael Elias Marques

Publikováno v: Frontiers in Virology, Vol 2 (2022)

Until December 2021, the COVID-19 pandemic has caused more than 5.5 million deaths. Vaccines are being deployed worldwide to mitigate severe disease and death, but continued transmission and the emergence of SARS-CoV-2 variants indicate that specific

Externí odkaz: https://doaj.org/article/a5ef3494e053423bab15254c1229c102