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pro vyhledávání: '"LY2811376"'
Autor:
Mercè Masana, Marianne B. Müller, Christian K.E. Jung, Lidia Blazquez-Llorca, Christiane Volbracht, Anders Brandt Elvang, Saak V. Ovsepian, Jochen Herms, Severin Filser
Publikováno v:
Biological psychiatry 77(8), 729-739 (2015). doi:10.1016/j.biopsych.2014.10.013
Background BACE1 (beta site amyloid precursor protein cleaving enzyme 1) is the rate limiting protease in amyloid β production, hence a promising drug target for the treatment of Alzheimer's disease. Inhibition of BACE1, as the major β-secretase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb421afb016d5a65583de63e68321280
https://pub.dzne.de/record/137858
https://pub.dzne.de/record/137858
Autor:
Sabina Tahirovic, Annika Wulf-Goldenberg, Christian Haass, Cyril Cheret, Paul Saftig, Florence R. Fricker, Alistair N. Garratt, Carmen Birchmeier, Hagen Wende, Michael Willem, Klaus-Armin Nave, David L.H. Bennett
Publikováno v:
The EMBO Journal
The EMBO journal 32(14), 2015-2028 (2013). doi:10.1038/emboj.2013.146
The EMBO journal 32(14), 2015-2028 (2013). doi:10.1038/emboj.2013.146
The protease β-secretase 1 (Bace1) was identified through its critical role in production of amyloid-β peptides (Aβ), the major component of amyloid plaques in Alzheimer's disease. Bace1 is considered a promising target for the treatment of this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacd5357a8fcb5c20b9ee2cb77c09aaf
https://hdl.handle.net/21.11116/0000-000D-3620-211858/00-001M-0000-0029-26BC-9
https://hdl.handle.net/21.11116/0000-000D-3620-211858/00-001M-0000-0029-26BC-9
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