Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos

Autor: Ospina, Diana, Rondón-Lagos, Milena, Villegas, Victoria E., Rodriguez-Leguizamon, Giovanni

Publikováno v: Cancer Management and Research
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario

Asbestos is one of the most important occupational carcinogens. Currently, about 125 million people worldwide are exposed to asbestos in the workplace. According to global estimates, at least 107,000 people die each year from lung cancer, mesotheliom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3feed2dab074821a1e99c7f9b63cbf6b
http://europepmc.org/articles/PMC6556979

Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment

Autor: Dennis W. McGraw, Yoshikazu Inoue, Yves Sabbagh, Jason D. Gardner, Kathryn A. Wikenheiser-Brokamp, Marko Jakopović, Francis X. McCormack, Atsushi Saito, Yasuaki Uehara, Lori B. Pitstick, Susan C. Schiavi, Kathleen LaSance, Nikolaos M. Nikolaidis, Jason C. Woods, Goksel Altinisik, James P. Bridges, Hassane Amlal

Publikováno v: Science Translational Medicine. 7

Pulmonary alveolar microlithiasis (PAM) is a rare, autosomal recessive lung disorder associated with progressive accumulation of calcium phosphate microliths. Inactivating mutations in SLC34A2, which encodes the NPT2b sodium-dependent phosphate cotra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1c723daf6c246ecf9ec63ecbfe00f9
https://doi.org/10.1126/scitranslmed.aac8577

Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment

Autor: Saito, A., Nikolaidis, N.M., Amlal, H., Uehara, Y., Gardner, J.C., LaSance, K., Pitstick, L.B., Bridges, J.P., Wikenheiser-Brokamp, K.A., McGraw, D.W., Woods, J.C., Sabbagh, Y., Schiavi, S.C., Altınıkışık,Göksel., Jakopovi, M., Inoue, Y., McCormack, F.X.

Pulmonary alveolar microlithiasis (PAM) is a rare, autosomal recessive lung disorder associated with progressive accumulation of calcium phosphate microliths. Inactivating mutations in SLC34A2, which encodes the NPT2b sodiumdependent phosphate cotran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3566::cb7b9bc5314556598f77e22bcd075dbc
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/9992

Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potentialA case study with structurally related piperazines

Autor: Ploemen, J.P., Kelder, J.C., Hafmans, T.G.M., Sandt, H. van de, Burgsteden, J.A. van, Saleminki, P.J., Esch, E. van

Publikováno v: Experimental and Toxicologic Pathology, 55, 5, pp. 347-55
Experimental and Toxicologic Pathology, 5, 55, 347-355
Experimental and Toxicologic Pathology, 55, 347-55

Contains fulltext : 59129.pdf (Publisher’s version ) (Closed access) Several cationic amphiphilic compounds are known to induce phospholipidosis, a condition primarily characterized by excessive accumulation of phospholipids in different cell types

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712472b9fec6499da908543d8ab4e18e
https://doi.org/10.1016/s0940-2993(04)70180-3

Alveolar macrophages suppress non-specific inflammation caused by inhalation challenge with trimellitic anhydride conjugated to albumin

Autor: Valstar, D.L., Schijf, M.A., Arts, J.H.E., Kuper, C.F., Nijkamp, F.P., Storm, G., Bloksma, N., Henricks, P.A.J.

Publikováno v: Archives of Toxicology, 9, 80, 561-571

Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter these inhaled compounds and were previously shown to affec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f5fb04e5f1a8758a7c08f10c915e1a9b
https://dspace.library.uu.nl/handle/1874/41710