Výsledky vyhledávání - "LUIS ALARCON"

Akademický článek

AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma

Autor: Nicolas Belforte, Jessica Agostinone, Luis Alarcon-Martinez, Deborah Villafranca-Baughman, Florence Dotigny, Jorge L. Cueva Vargas, Adriana Di Polo

Publikováno v: Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-19 (2021)

Abstract Background The maintenance of complex dendritic arbors and synaptic transmission are processes that require a substantial amount of energy. Bioenergetic decline is a prominent feature of chronic neurodegenerative diseases, yet the signaling

Externí odkaz: https://doaj.org/article/76f1a87c23d14f66ba48713b59068c73

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Akademický článek

Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion

Autor: Luis Alarcon-Martinez, Sinem Yilmaz-Ozcan, Muge Yemisci, Jesse Schallek, Kıvılcım Kılıç, Deborah Villafranca-Baughman, Alp Can, Adriana Di Polo, Turgay Dalkara

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-21 (2019)

Abstract Increasing evidence indicates that pericytes are vulnerable cells, playing pathophysiological roles in various neurodegenerative processes. Microvascular pericytes contract during cerebral and coronary ischemia and do not relax after re-open

Externí odkaz: https://doaj.org/article/a09d8e942c8244058951f69e2339e545

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Akademický článek

Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

Autor: Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis, Adriana Di Polo

Publikováno v: Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-20 (2017)

Abstract Background Tau is an axon-enriched protein that binds to and stabilizes microtubules, and hence plays a crucial role in neuronal function. In Alzheimer’s disease (AD), pathological tau accumulation correlates with cognitive decline. Substa

Externí odkaz: https://doaj.org/article/ba4cd4b957d247038e5bb2d2f25f57cd

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Akademický článek

Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

Autor: Luis Alarcon-Martinez, Sinem Yilmaz-Ozcan, Muge Yemisci, Jesse Schallek, Kıvılcım Kılıç, Alp Can, Adriana Di Polo, Turgay Dalkara

Publikováno v: eLife, Vol 7 (2018)

Recent evidence suggests that capillary pericytes are contractile and play a crucial role in the regulation of microcirculation. However, failure to detect components of the contractile apparatus in capillary pericytes, most notably α-smooth muscle

Externí odkaz: https://doaj.org/article/04b0fe33bf6841b9ab53e3e64da4fb36

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Akademický článek

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Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma

Autor: Luis Alarcon-Martinez, Yukihiro Shiga, Deborah Villafranca-Baughman, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Jorge L. Cueva Vargas, Adriana Di Polo

Publikováno v: Proceedings of the National Academy of Sciences. 119

Significance The current lack of understanding of the mechanisms leading to neurovascular deficits in glaucoma is a major knowledge gap in the field. Retinal pericytes regulate microcirculatory blood flow and coordinate neurovascular coupling through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486fd78d346030d317c9a500a7cfdf1d
https://doi.org/10.1073/pnas.2110329119

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Restoration of mitochondria axonal transport by adaptor Disc1 supplementation prevents neurodegeneration and rescues visual function

Autor: Heberto Quintero, Yukihiro Shiga, Nicolas Belforte, Luis Alarcon-Martinez, Sana El Hajji, Deborah Villafranca-Baughman, Florence Dotigny, Adriana Di Polo

Publikováno v: Cell Reports. 40:111324

Deficits in mitochondrial transport are a common feature of neurodegenerative diseases. We investigated whether loss of components of the mitochondrial transport machinery impinge directly on metabolic stress, neuronal death, and circuit dysfunction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb166b6504cd146d613472eb91af1863
https://doi.org/10.1016/j.celrep.2022.111324

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