Výsledky vyhledávání - "LUIGI G. MARZILLI"

Linear Bidentate Ligands (L) with Two Terminal Pyridyl N-Donor Groups Forming Pt(II)LCl2 Complexes with Rare Eight-Membered Chelate Rings

Autor: Patricia A. Marzilli, Luigi G. Marzilli, Kokila Ranasinghe, Svetlana Pakhomova

Publikováno v: Inorganic Chemistry. 57:12756-12768

NMR and X-ray diffraction studies were conducted on Pt(II)LCl2 complexes prepared with the new N-donor ligands N(SO2R)Me ndpa (R = Me, Tol; n = 2, 4). These ligands differ from N(H)dpa (di-2-picolylamine) in having the central N within a tertiary sul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d46f4a1ae8301c9678fee30fae79e2f
https://doi.org/10.1021/acs.inorgchem.8b01943

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Synthesis and Characterization of Pt(II) Complexes with Pyridyl Ligands: Elongated Octahedral Ion Pairs and Other Factors Influencing 1H NMR Spectra

Autor: Patricia A. Marzilli, Nerissa A. Lewis, Svetlana Pakhomova, Luigi G. Marzilli

Publikováno v: Inorganic Chemistry. 56:9781-9793

Our goal is to develop convenient methods for obtaining trans-[PtII(4-Xpy)2Cl2] complexes applicable to 4-substituted pyridines (4-Xpy) with limited volatility and water solubility, properties typical of 4-Xpy, with X being a moiety targeting drug de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c515a479e8337d0556a99663c533906e
https://doi.org/10.1021/acs.inorgchem.7b01294

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A Very Rare Example of a Structurally Characterized 3′-GMP Metal Complex. NMR and Synthetic Assessment of Adducts Formed by Guanine Derivatives with [Pt(Ltri)Cl]Cl Complexes with an N,N′,N″ Tridentate Ligand (Ltri) Terminated by Imidazole Rings

Autor: Patricia A. Marzilli, Svetlana Pakhomova, Luigi G. Marzilli, Kokila Ranasinghe

Publikováno v: Inorganic Chemistry. 56:8462-8477

[Pt(N(R)-1,1'-Me2dma)Cl]Cl complexes with tridentate ligands (bis(1-methyl-2-methylimidazolyl)amine, R = H; N-(methyl)bis(1-methyl-2-methylimidazolyl)amine, R = Me) were prepared in order to investigate Pt(N(R)-1,1'-Me2dma)G adducts (G = monodentate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::166beec8cddca55e67deaf7aa6493ca4
https://doi.org/10.1021/acs.inorgchem.7b01176

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Monoanionic 99m Tc-tricarbonyl-aminopolycarboxylate complexes with uncharged pendant groups: Radiosynthesis and evaluation as potential renal tubular tracers

Autor: Malgorzata Lipowska, Jeffrey Klenc, Andrew J. Taylor, Luigi G. Marzilli, Nashwa Jarkas

Publikováno v: Nuclear Medicine and Biology. 47:48-55

Introduction 99m Tc(CO) 3 -nitrilotriacetic acid, 99m Tc(CO) 3 (NTA), is a new renal tubular agent with pharmacokinetic properties comparable to those of 131 I-OIH but the clearance of 99m Tc(CO) 3 (NTA) and 131 I-OIH is still less than the clearance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::287c0a79bf390dce20634d0efc87086d
https://doi.org/10.1016/j.nucmedbio.2016.12.008

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fac-(99m)Tc/Re-tricarbonyl complexes with tridentate aminocarboxyphosphonate ligands: suitability of the phosphonate group in chelate ligand design of new imaging agents

Autor: Luigi G. Marzilli, Jeffrey Klenc, Malgorzata Lipowska, Andrew J. Taylor

Ligands that coordinate via dianionic phosphonate groups have not been widely utilized in radiopharmaceuticals. N-(phosphonomethyl)iminodiacetic acid (1, PMIDA) and N-(phosphonomethyl)glycine (2, PMG) were investigated as new chelators for the (99m)T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c33b31d5f1c45e3b456e901b5f1f65
https://europepmc.org/articles/PMC6385875/

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Guanine nucleobase adducts formed by a monofunctional complex: [Pt(N-(6-methyl-2-picolyl)-N-(2-picolyl)amine)Cl]Cl

Autor: Svetlana Pakhomova, Patricia A. Marzilli, Luigi G. Marzilli, Chase Andrepont

Publikováno v: Journal of Inorganic Biochemistry. 153:219-230

Monofunctional Pt(II) complexes bind to G residues in DNA and, if the carrier ligands are bulky, cause DNA structural distortions that lead to anticancer activity. We assessed the steric effects of the tridentate carrier ligand, N(H)6-Medpa (N-(6-met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930580fc2cd16e519ae416e4d3603bf4
https://doi.org/10.1016/j.jinorgbio.2015.06.023

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Structure and Properties of fac-[ReI(CO)3(NTA)]2– (NTA3– = Trianion of Nitrilotriacetic Acid) and fac-[ReI(CO)3(L)]n– Analogues Useful for Assessing the Excellent Renal Clearance of the fac-[99mTcI(CO)3(NTA)]2– Diagnostic Renal Agent

Autor: Pramuditha Abhayawardhana, Malgorzata Lipowska, Andrew J. Taylor, Luigi G. Marzilli, Jeffrey Klenc

Publikováno v: Inorganic Chemistry. 54:6281-6290

We previously identified two new agents based on the [99mTcVO]3+ core with renal clearances in human volunteers 30% higher than that of the widely used clinical tracer 99mTc-MAG3 (MAG35– = penta-anion of mercaptoacetyltriglycine). However, renal ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::908ec071a949f6fbbae0359bc5f5704c
https://doi.org/10.1021/acs.inorgchem.5b00584

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Unusual Example of Chelate Ring Opening upon Coordination of the 9-Ethylguanine Nucleobase to [Pt(di-(6-methyl-2-picolyl)amine)Cl]Cl

Autor: Svetlana Pakhomova, Luigi G. Marzilli, Chase Andrepont, Patricia A. Marzilli

Publikováno v: Inorganic Chemistry. 54:4895-4908

Anticancer-active monofunctional Pt(II) complexes have bulky carrier ligands and bind to G residues in DNA, causing structural distortions. To gain fundamental chemical information on such monofunctional adducts, we assessed the 9-ethylguanine (9-EtG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756b7b9eb3f7fd1749b6f61bf5ff2083
https://doi.org/10.1021/acs.inorgchem.5b00496

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