Zobrazeno 1 - 10
of 50
pro vyhledávání: '"LUCIA CARMELA COSENZA"'
Autor:
Maria Rita Gamberini, Cristina Zuccato, Matteo Zurlo, Lucia Carmela Cosenza, Alessia Finotti, Roberto Gambari
Publikováno v:
Hematology Reports, Vol 15, Iss 3, Pp 432-439 (2023)
The β-thalassemias are a group of monogenic hereditary hematological disorders caused by deletions and/or mutations of the β-globin gene, leading to low or absent production of adult hemoglobin (HbA). For β-thalassemia, sirolimus has been under cl
Externí odkaz:
https://doaj.org/article/cb0e102625de42d687cf73b2b04b12dd
Autor:
Cristina Zuccato, Lucia Carmela Cosenza, Chiara Tupini, Alessia Finotti, Gianni Sacchetti, Daniele Simoni, Roberto Gambari, Ilaria Lampronti
Publikováno v:
Molecules, Vol 29, Iss 1, p 8 (2023)
Induction of fetal hemoglobin (HbF) is highly beneficial for patients carrying β-thalassemia, and novel HbF inducers are highly needed. Here, we describe a new class of promising HbF inducers characterized by an isoxazole chemical skeleton and obtai
Externí odkaz:
https://doaj.org/article/e1abf3e761f14c6eaf81ed7b2c14153a
Autor:
Roberto Gambari, Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Jessica Gasparello, Alessia Finotti, Maria Rita Gamberini, Marco Prosdocimi
Publikováno v:
Biology, Vol 12, Iss 9, p 1202 (2023)
In this review article, we present the fascinating story of rapamycin (sirolimus), a drug able to induce γ-globin gene expression and increased production of fetal hemoglobin (HbF) in erythroid cells, including primary erythroid precursor cells (ErP
Externí odkaz:
https://doaj.org/article/9b516fe69a7b4406aa1fd7419ea2538d
Autor:
Alessia Finotti, Ilaria Lampronti, Roberto Gambari, Cristina Zuccato, Marco Prosdocimi, Monica Borgatti, Lucia Carmela Cosenza
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Drug repositioning and the relevance of orphan drug designation for β-thalassemia is reviewed. Drug repositioning and similar terms ('drug repurposing', 'drug reprofiling', 'drug redirecting', ‘drug rescue’, ‘drug re-tasking’ and/or 'drug re
Externí odkaz:
https://doaj.org/article/39076482c34641b6a1f45b12ca0a19af
Autor:
Lucia Carmela Cosenza, Jessica Gasparello, Nicola Romanini, Matteo Zurlo, Cristina Zuccato, Roberto Gambari, Alessia Finotti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 507-523 (2021)
Gene editing by the CRISPR-Cas9 nuclease system technology can be considered among the most promising strategies to correct hereditary mutations in a variety of monogenic diseases. In this paper, we present for the first time the correction, by CRISP
Externí odkaz:
https://doaj.org/article/c341716d7de144c7b048cb6790ed1339
Autor:
Chiara Papi, Jessica Gasparello, Matteo Zurlo, Lucia Carmela Cosenza, Roberto Gambari, Alessia Finotti
Publikováno v:
Non-Coding RNA, Vol 9, Iss 2, p 29 (2023)
(1) Background: MicroRNAs are involved in the expression of the gene encoding the chloride channel CFTR (Cystic Fibrosis Transmembrane Conductance Regulator); the objective of this short report is to study the effects of the treatment of bronchial ep
Externí odkaz:
https://doaj.org/article/4b1c2c4c6c6049969c434e3cd3914a11
Autor:
Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Jessica Gasparello, Chiara Papi, Elisabetta D’Aversa, Giulia Breveglieri, Ilaria Lampronti, Alessia Finotti, Monica Borgatti, Chiara Scapoli, Alice Stievano, Monica Fortini, Eric Ramazzotti, Nicola Marchetti, Marco Prosdocimi, Maria Rita Gamberini, Roberto Gambari
Publikováno v:
Therapeutic Advances in Hematology, Vol 13 (2022)
Introduction: β-thalassemia is caused by autosomal mutations in the β-globin gene, which induce the absence or low-level synthesis of β-globin in erythroid cells. It is widely accepted that a high production of fetal hemoglobin (HbF) is beneficial
Externí odkaz:
https://doaj.org/article/3a428c6ac29340b587bac650085e82e1
Autor:
Jessica Gasparello, Chiara Papi, Matteo Zurlo, Lucia Carmela Cosenza, Giulia Breveglieri, Cristina Zuccato, Roberto Gambari, Alessia Finotti
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266419 (2022)
The pandemic caused by the SARS-CoV-2 virus (COVID-19) is still a major health issue. The COVID-19 pandemic has forced the university teaching to consider in high priority the switch from in-presence teaching to remote teaching, including laboratory
Externí odkaz:
https://doaj.org/article/31b128fba2004337b5d0ab93a8521807
Autor:
Aikaterini Nanou, Chrisavgi Toumpeki, Pavlos Fanis, Nicoletta Bianchi, Lucia Carmela Cosenza, Cristina Zuccato, George Sentis, Giorgos Giagkas, Coralea Stephanou, Marios Phylactides, Soteroula Christou, Michalis Hadjigavriel, Maria Sitarou, Carsten W. Lederer, Roberto Gambari, Marina Kleanthous, Eleni Katsantoni
Publikováno v:
Haematologica, Vol 106, Iss 4 (2020)
Externí odkaz:
https://doaj.org/article/3de2f56a7d294f9faa59acb2b535f529
Autor:
Giulia Breveglieri, Nicoletta Bianchi, Lucia Carmela Cosenza, Maria Rita Gamberini, Francesco Chiavilli, Cristina Zuccato, Giulia Montagner, Monica Borgatti, Ilaria Lampronti, Alessia Finotti, Roberto Gambari
Publikováno v:
BMC Medical Genetics, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract Background Increase of the expression of γ-globin gene and high production of fetal hemoglobin (HbF) in β-thalassemia patients is widely accepted as associated with a milder or even asymptomatic disease. The search for HbF-associated polym
Externí odkaz:
https://doaj.org/article/e7ec5ead3e174bf499cf83cfe58fc404