Zobrazeno 1 - 10
of 14 147
pro vyhledávání: '"LTP"'
Autor:
Amir Barzegar Behrooz, Mohamad-Reza Aghanoori, Maryam Nazari, Hamid Latifi-Navid, Fatemeh Vosoughian, Mojdeh Anjomani, Jabar Lotfi, Abolhassan Ahmadiani, Afsaneh Eliassi, Fatemeh Nabavizadeh, Elham Soleimani, Saeid Ghavami, Fariba Khodagholi, Javad Fahanik-Babaei
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Alzheimer’s disease (AD) is the most prevalent type of dementia. Its causes are not fully understood, but it is now known that factors like mitochondrial dysfunction, oxidative stress, and compromised ion channels contribute to its onset a
Externí odkaz:
https://doaj.org/article/52d9a9476105415ba6e87daf8b2f1016
Publikováno v:
Future Pharmacology, Vol 4, Iss 3, Pp 494-509 (2024)
Ampakines are a class of orally available positive allosteric modulators of the AMPA-glutamate receptor (AMPAR) and have therapeutic implications for neurological/neuropsychiatric disorders in which AMPAR signaling is compromised. Low-impact ampakine
Externí odkaz:
https://doaj.org/article/64ab3660dce846598b9b47f1d4571137
Autor:
Sehyun Chae, Hyun-ju Lee, Ha-Eun Lee, Jieun Kim, Yoo Joo Jeong, Yuxi Lin, Hye Yun Kim, Geoffray Leriche, Rachel S. Ehrlich, Sascha Castro Lingl, Min-Duk Seo, Young-Ho Lee, Jerry Yang, Jae-Ick Kim, Hyang-Sook Hoe
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-34 (2024)
Abstract Background We recently reported that the dopamine (DA) analogue CA140 modulates neuroinflammatory responses in lipopolysaccharide-injected wild-type (WT) mice and in 3-month-old 5xFAD mice, a model of Alzheimer’s disease (AD). However, the
Externí odkaz:
https://doaj.org/article/320a17cb8a82451c8f0b059ff0d03f14
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract The brain responds to experience through modulation of synaptic transmission, that is synaptic plasticity. An increase in the strength of synaptic transmission is manifested as long-term potentiation (LTP), while a decrease in the strength o
Externí odkaz:
https://doaj.org/article/c384dfe5e91a4758845983bb5334c5c5
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Synaptopodin, an actin-associated protein found in a subset of dendritic spines in telencephalic neurons, has been described to influence both functional and morphological plasticity under various plasticity paradigms. Synaptopodin is necessary and s
Externí odkaz:
https://doaj.org/article/1860d2bf22484f0ebb784378cc65fda1
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
Idiopathic anaphylaxis (IA) is a severe allergic reaction without identifiable external triggers, presenting significant challenges in diagnosis and management. However, growing evidence suggests that many cases classified as idiopathic may actually
Externí odkaz:
https://doaj.org/article/77c07aa7aac943ada9a6bd5235d177ad
Autor:
Francesco Longo
Publikováno v:
eLife, Vol 13 (2024)
The neurotransmitter dopamine helps form long-term memories by increasing the production of proteins through a unique signaling pathway.
Externí odkaz:
https://doaj.org/article/e26d53fec0f44a408fd6ee1b0c129020
Publikováno v:
International Journal of Electrical Power & Energy Systems, Vol 161, Iss , Pp 110197- (2024)
Small-signal stability analysis is essential for the safe operation and parameter design of power electronic-dominated grids. Unbalanced conditions introduce more frequency-coupling terms, which are unneglectable in the stability assessment. This pap
Externí odkaz:
https://doaj.org/article/cd7c3d3166804f6b95e56e3813c0ea82
Autor:
Nathaniel A. Swift, Qian Yang, Hannah M. Jester, Xueyan Zhou, Adam Manuel, Bruce E. Kemp, Gregory R. Steinberg, Tao Ma
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106664- (2024)
AMP-activated protein kinase (AMPK) is an αβγ heterotrimer protein kinase that functions as a molecular sensor to maintain energy homeostasis. Accumulating evidence suggests a role of AMPK signaling in the regulation of synaptic plasticity and cog
Externí odkaz:
https://doaj.org/article/7fa0064dd409485ab3e1e18d09af9746
Autor:
Alyssa R. Kniffin, Lisa A. Briand
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
Disruptions in glutamate homeostasis within the mesolimbic reward circuitry may play a role in the pathophysiology of various reward related disorders such as major depressive disorders, anxiety, and substance use disorders. Clear sex differences hav
Externí odkaz:
https://doaj.org/article/77ecb46086af40b8a2f15ce199256910