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Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis

Autor: Jianyang Liu, Helena Idborg, Marina Korotkova, Kristina Lend, Ronald van Vollenhoven, Jon Lampa, Anna Rudin, Dan Nordström, Bjorn Gudbjornsson, Gerdur Gröndal, Till Uhlig, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Michael Nurmohamed, Per-Johan Jakobsson

Publikováno v: Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-9 (2024)

Abstract Background Disease-modifying antirheumatic drugs (DMARDs) are widely used for treating rheumatoid arthritis (RA). However, there are no established biomarkers to predict a patient’s response to these therapies. Prostanoids, encompassing pr

Externí odkaz: https://doaj.org/article/2260d524aa2942c78c1315d2c24d7266

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Pengaruh Pemberian Vitamin C terhadap Kadar Leukotrien Urin pada Pasien Asma Anak

Autor: Cece Alfalah, Gustina Lubis, Finny F Yani, Nur I Lipoeto

Publikováno v: Sari Pediatri, Vol 16, Iss 6, Pp 416-20 (2016)

Latar belakang. Pada asma anak terdapat peningkatan kadar leukotrien darah dengan hasil metabolit akhir berupa leukotrien E4(LTE4). Vitamin C dapat menghambat lipoksigenase sehingga menurunkan kadar LTE4 urin sejalan dengan perbaikan klinis asma. Tuj

Externí odkaz: https://doaj.org/article/55369bb73fa8488e96eca14f47af5c08

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Biomarkers of Exposure and Potential Harm in Two Weeks of Smoking Abstinence: Changes in Biomarkers of Platelet Function, Oxidative Stress, and Inflammation

Autor: Patrudu Makena, Eric Scott, Peter Chen, Hsiao-Pin Liu, Bobbette A. Jones, Gaddamanugu L. Prasad

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6286

Chronic cigarette smoking is a major risk factor for many serious diseases. While complete cessation of smoking is the best option to reduce harm from smoking, adverse impacts of smoking on health could persist for several years after cessation. Ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae2c39326adf493da370ed68234005f

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Akademický článek

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Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

Autor: Brücher Björn L.D.M., Jamall Ijaz S.

Publikováno v: 4 open, Vol 2, p 8 (2019)

A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease. Chronic inflammation involves many cell types with numerous cytokin

Externí odkaz: https://doaj.org/article/c8b7ef5320944228ae4731a0b496ece9

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Synopsis: Special Issue on 'Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer'

Autor: Brücher Björn L.D.M., Jamall Ijaz S.

Publikováno v: 4 open, Vol 2, p 28 (2019)

It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect. Here, decades of thinking based on

Externí odkaz: https://doaj.org/article/6690269480214380bb0f15776f7a247f

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Comparative study between conventional and new methods in defining the cause of death from anaphylactic shock

Autor: Costantino, A., Mezzetti, E., de Matteis, A., Volonnino, G., de Simone, S., Fazio, V.

Publikováno v: La Clinica terapeutica. 172(4)

Anaphylaxis is defined as a rapid systemic reaction that develops in individuals previously exposed to specific allergens. The new exposure causes systemic cellular degranulation, which in turn leads to cardiovascular and respiratory changes that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e8aab7d5509dfa5cb52e5e21fc5afc03
https://pubmed.ncbi.nlm.nih.gov/34247221

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The functional link between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the onset of inflammation

Autor: Asif J. Iqbal, Gian Marco Casillo, Nicola Mascolo, Francesco Maione, Federica Raucci

Many years have elapsed since the discovery of anti-inflammatories as effective therapeutics for the treatment of inflammatory-related diseases, but we are still uncovering their various mechanisms of action. Recent biochemical and pharmacological st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708b6c9f2cefb700e77c6a9ae114d0f0
http://hdl.handle.net/11588/809237

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