LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery

Autor: Brachet, Anna, Norwood, Stephanie, Brouwers, Jos F, Palomer, Ernest, Helms, J Bernd, Dotti, Carlos G, Esteban, José A, LS Veterinaire biochemie, Sub MS-faciliteit, Dep Biochemie en Celbiologie, LS Algemeen B&C, B&C BRC-SIB-TR

Publikováno v: Journal of Cell Biology, 208(6), 791. Rockefeller University Press
The Journal of Cell Biology

Neurotransmitter receptor trafficking during synaptic plasticity requires the concerted action of multiple signaling pathways and the protein transport machinery. However, little is known about the contribution of lipid metabolism during these proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e98817510397820c37511cf0e14c13
https://doi.org/10.1083/jcb.201407122

Interaction of GAPR-1 with lipid bilayers is regulated by alternative homodimerization

Autor: van Galen, Josse, Olrichs, Nick K, Schouten, Arie, Serrano, Ramon L, Nolte-'t Hoen, Esther N M, Eerland, Ruud, Kaloyanova, Dora, Gros, Piet, Helms, J Bernd, LS Veterinaire biochemie, Sub Crystal and Structural Chemistry, Dep Biochemie en Celbiologie, LS Algemeen B&C

Publikováno v: Biochimica et Biophysica Acta, 1818(9), 2175

Golgi-Associated Plant Pathogenesis-Related protein 1 (GAPR-1) is a mammalian protein that belongs to the superfamily of plant pathogenesis related proteins group 1 (PR-1). GAPR-1 is a peripheral membrane-binding protein that strongly associates with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dccbdd92cbf8c5fe959ccd1c5c17e3

Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response

Autor: Houthuijzen, Julia M, Daenen, Laura G M, Roodhart, Jeanine M L, Oosterom, Ilse, van Jaarsveld, Marijn T M, Govaert, Klaas M, Smith, Michelle E, Sadatmand, Sahar J, Rosing, Hilde, Kruse, Fabian, Helms, Bernd J, van Rooijen, Nico, Beijnen, Jos H, Haribabu, Bodduluri, van de Lest, Chris H A, Voest, Emile E, LS Equine Muscoskeletal Biology, LS Veterinaire biochemie, Dep Biochemie en Celbiologie, LS Algemeen B&C, Sub Clinical Pharmacology, B&C BRC-SIB-TR, Tissue Repair, UIPS - Utrecht Institute for Pharmaceutical Sciences

Publikováno v: Nature Communications [E], 5. Nature Publishing Group
Nature Communications, 5:5275. Nature Publishing Group
Houthuijzen, J M, Daenen, L G M, Roodhart, J M L, Oosterom, I, van Jaarsveld, M T M, Govaert, K M, Smith, M E, Sadatmand, S J, Rosing, H, Kruse, F, Helms, B J, van Rooijen, N, Beijnen, J H, Haribabu, B, van de Lest, C H A & Voest, E E 2014, ' Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response ', Nature Communications, vol. 5, 5275 . https://doi.org/10.1038/ncomms6275

Host responses to systemic anti-cancer treatment play important roles in the development of anti-cancer drug resistance. Here we show that F4/80(+)/CD11b(low) splenocytes mediate the resistance to DNA-damaging chemotherapeutics induced by two platinu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c15fef46461e6937de28d1705dfb451
https://dspace.library.uu.nl/handle/1874/310466

The Cumulus Cell Layer Protects Bovine Maturing Oocyte Against Fatty Acid-Induced Lipotoxicity

Autor: Lolicato, Francesca, Brouwers, Jos F., van de Lest, Chris H.A., Wubbolts, Richard, Aardema, Hilde, Priore, Paola, Roelen, Bernard A.J., Helms, J. Bernd, Gadella, Bart M, ES/FAH BRC, B&C BRC-SIB-TR, Biology of Reproductive Cells, B&C BRC-SIB, Fertility & Reproduction, Infection & Immunity, LS Veterinaire biochemie, Sub MS-faciliteit, LS Equine Muscoskeletal Biology, LS Celbiologie-Algemeen, Sub Center for Cell Imaging, LS GZ Landbouwhuisdieren, LS Klinische Reproductie, LS Voortplanting Inwendige Ziekten, Sub Celbiologisch lab., Dep Biochemie en Celbiologie, LS Algemeen B&C, Sub Biologie van de mannelijke gameet, Sub Reproductie mannelijk

Publikováno v: Biology of Reproduction, 92(1), 1. Society for the Study of Reproduction

Mobilization of fatty acids from adipose tissue during metabolic stress increases the amount of free fatty acids in blood and follicular fluid and is associated with impaired female fertility. In a previous report we described the effects of the thre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::f175624ec1a8ae32634783e6da58cc91
https://dspace.library.uu.nl/handle/1874/330557

Involvement of Bicarbonate-Induced Radical Signaling in Oxysterol Formation and Sterol Depletion of Capacitating Mammalian Sperm During In Vitro Fertilization

Autor: Boerke, Arjan, Brouwers, Jos F., Olkkonen, Vesa M., van de Lest, Chris H A, Sostaric, Edita, Schoevers, Eric J., Helms, J. Bernd, Gadella, Barend M., Sub Celbiologisch lab., Faculty of Veterinary Medicine Research Groups, LS Veterinaire biochemie, Sub MS-faciliteit, LS Equine Muscoskeletal Biology, Dep Biochemie en Celbiologie, LS Algemeen B&C, Sub Biologie van de mannelijke gameet, Sub Reproductie mannelijk, Biology of Reproductive Cells

Publikováno v: Biology of Reproduction, 88(1), 1. Society for the Study of Reproduction

This study demonstrates for the first time that porcine and mouse sperm incubated in capacitation media supplemented with bicarbonate produce oxysterols. The production is depen- dent on a reactive oxygen species (ROS) signaling pathway that is activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::7dee00e0bf82fce3a39d797dbfeddaa5
https://dspace.library.uu.nl/handle/1874/315418