Zobrazeno 1 - 6
of 6
pro vyhledávání: '"LP, lectin pathway"'
Publikováno v:
The Journal of Biological Chemistry
Lack of simple and robust methods to determine complement activation in human serum induced by antigen-antibody complexes is a major hurdle for monitoring therapeutic antibody drug quality and stability. Dezamizumab is a humanized IgG1 monoclonal ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f933513331869a4d84c72fbc9ba7fd
http://europepmc.org/articles/PMC8463879
http://europepmc.org/articles/PMC8463879
Publikováno v:
The Journal of Biological Chemistry
Inhibition of the alternative pathway (AP) of complement by saliva from Anopheles mosquitoes facilitates feeding by blocking production of the anaphylatoxins C3a and C5a, which activate mast cells leading to plasma extravasation, pain, and itching. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56b0ff8857a97987bd856e00dd37e49
https://pubmed.ncbi.nlm.nih.gov/33199367
https://pubmed.ncbi.nlm.nih.gov/33199367
Autor:
Rolf T. Urbanus, Kim Dijkxhoorn, Karen Silence, Peter Boross, Elisabeth de Zeeuw, Louis Boon, Jan Meeldijk, Christophe Blanchetot, Jeanette H. W. Leusen, Sofie Gabriels, Henny G. Otten, Liesbeth Van de Ven, Kevin Budding, Hans de Haard, Jean-Michel Percier, Rob Holgate, Peter J. Simons, Johanna Wildemann, C. Erik Hack, Inge Van de Walle, Linda J. Cox, Cafer Yildiz
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background Activation of the classical and lectin pathway of complement may contribute to tissue damage and organ dysfunction of antibody-mediated diseases and ischemia-reperfusion conditions. Complement factors are being considered as targets for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fe17fec6eb2a3b3724be8ca3d9a198
https://doi.org/10.1016/j.jaci.2020.08.028
https://doi.org/10.1016/j.jaci.2020.08.028
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 4, Pp 316-322 (2015)
Acta Pharmaceutica Sinica B, Vol 5, Iss 4, Pp 316-322 (2015)
Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a957bcdfda77609b1333850e0b66bf
http://europepmc.org/articles/PMC4629277
http://europepmc.org/articles/PMC4629277
Autor:
Martínez-Barricarte, Rubén, Heurich, Meike, López-Perrote, Andrés, Tortajada, Agustin, Pinto, Sheila, López-Trascasa, Margarita, Sánchez-Corral, Pilar, Morgan, B. Paul, Llorca, Oscar, Harris, Claire L., Rodríguez de Córdoba, Santiago
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Molecular Immunology
Consejería de Sanidad de la Comunidad de Madrid
Molecular Immunology
Highlights • Mutations in C3 have been associated with aHUS and other glomerulopathies. • aHUS-associated C3 mutants R592W, R161W, and I1157T impair regulation by MCP, but not by FH. • EM analysis provides the structural basis for the functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::55295c489a9386cf1427c8a49fe646f9
https://saludmadrid.ibai.com/handle/20.500.12530/22195
https://saludmadrid.ibai.com/handle/20.500.12530/22195
Autor:
Wu M; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China., Li H; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China., Zhang Y; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China., Chen D; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2015 Jul; Vol. 5 (4), pp. 316-22. Date of Electronic Publication: 2015 Apr 07.