Impaired Luminal Control of Intestinal Macrophage Maturation in Patients With Ulcerative Colitis During RemissionSummary

Autor: Otto Savolainen, Johanna Sundin, Stefan Isaksson, Hans Strid, Lena Öhman, Lujain Maasfeh, Maria K. Magnusson, Anetta Härtlova, Georgios Mavroudis

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1415-1432 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Intestinal macrophages adopt a hyporesponsive phenotype through education by local signals. Lack of proper macrophage maturation in patients with ulcerative colitis (UC) in remission may initiate gut inflammation. The aim, therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ce8b670ac92e77145e76a5dcc8b14f
http://www.sciencedirect.com/science/article/pii/S2352345X21001193

Lack of Mucosal Cholinergic Innervation Is Associated With Increased Risk of Enterocolitis in Hirschsprung's Disease

Autor: Simone Keck, Virginie Galati-Fournier, Urs Kym, Michèle Moesch, Jakob Usemann, Isabelle Müller, Ulrike Subotic, Sasha J. Tharakan, Thomas Krebs, Eleuthere Stathopoulos, Peter Schmittenbecher, Dietmar Cholewa, Philipp Romero, Bertram Reingruber, Elisabeth Bruder, NIG Study Group, Stefan Holland-Cunz

Publikováno v: Keck, Simone; Galati-Fournier, Virginie; Kym, Urs; Moesch, Michèle; Usemann, Jakob; Müller, Isabelle; Subotic, Ulrike; Tharakan, Sasha J.; Krebs, Thomas; Stathopoulos, Eleuthere; Schmittenbecher, Peter; Cholewa, Dietmar; Romero, Philipp; Reingruber, Bertram; Bruder, Elisabeth; NIG, Study Group; Holland-Cunz, Stefan (2021). Lack of Mucosal Cholinergic Innervation Is Associated With Increased Risk of Enterocolitis in Hirschsprung’s Disease. Cellular and molecular gastroenterology and hepatology, 12(2), pp. 507-545. Elsevier 10.1016/j.jcmgh.2021.03.004
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 507-545 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Hirschsprung’s disease (HSCR) is a congenital intestinal motility disorder defined by the absence of enteric neuronal cells (ganglia) in the distal gut. The development of HSCR-associated enterocolitis remains a life-threatening c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1edb3c50b54c24a0aeb72dbf83fb5b9
https://doi.org/10.5167/uzh-216782

Toll-Like Receptor 7 Agonist–Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells

Autor: Ryo Aoki, Toshiaki Teratani, Mari Mochizuki Arai, Kentaro Miyamoto, Yohei Mikami, Shinta Mizuno, Yosuke Harada, Ena Nomura, Takanori Kanai, Tomohisa Sujino, Hiroki Kiyohara, Makoto Naganuma, Yuzo Koda, Tadakazu Hisamatsu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 135-156 (2019)

Background & Aims Psoriasis and inflammatory bowel disease (IBD) are both chronic inflammatory diseases occurring in the skin and gut, respectively. It is well established that psoriasis and IBD have high concordance rates, and similar changes in imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668b6a6b782f67938742bda84ab27a4c
https://doi.org/10.1016/j.jcmgh.2018.09.010

The Microbiome Activates CD4 T-cell–mediated Immunity to Compensate for Increased Intestinal Permeability

Autor: Anne Sailer, Sarkis K. Mazmanian, Jerrold R. Turner, Karen L. Edelblum, Irene Thomsen, Chen Dong, Rima McLeod, Sarina Ravens, Matthew A. Odenwald, Gurminder Singh, Immo Prinz, Kamal El Bissati, Sandeep Gurbuxani, Severine Cao, Gil Sharon

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 2, Pp 285-297 (2017)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Despite a prominent association, chronic intestinal barrier loss is insufficient to induce disease in human subjects or experimental animals. We hypothesized that compensatory mucosal immune activation might protect individuals with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dffbd9a89ead44ab601abe9f6bc372a
https://doi.org/10.1016/j.jcmgh.2017.06.001

Mesenchymal stem/stromal cell-based therapy for the treatment of rheumatoid arthritis: An update on preclinical studies

Autor: Mercedes Lopez-Santalla, Juan A. Bueren, Marina I. Garin

Publikováno v: EBioMedicine, Vol 69, Iss, Pp 103427-(2021)
EBioMedicine

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and progressive joint destruction and is a primary cause of disability worldwide. Despite the existence of numerous anti-rheumatic drugs, a sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59ac03e508af98279e7efcb573e18b9
https://doi.org/10.1016/j.ebiom.2021.103427