Zobrazeno 1 - 10
of 859
pro vyhledávání: '"LOXL2"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract LOXL2, an enzyme belonging to the LOX family, facilitates the cross-linking of extracellular matrix (ECM) elements. However, the roles of the LOXL2 gene in mechanisms of oncogenesis and tumor development have not been clearly defined. In thi
Externí odkaz:
https://doaj.org/article/d5003ba33aa1485795138cdb64810c4f
Autor:
Rong Zeng, Dong Zhang, Jintao Zhang, Yun Pan, Xiaofei Liu, Qian Qi, Jiawei Xu, Changjuan Xu, Shuochuan Shi, Junfei Wang, Tian Liu, Liang Dong
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Airway epithelium is an important component of airway structure and the initiator of airway remodeling in asthma. The changes of extracellular matrix (ECM), such as collagen deposition and structural disturbance, are typical patho
Externí odkaz:
https://doaj.org/article/51f01c9620e84c57b3efc2a3f925b9d2
Autor:
Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul Skipp, Naftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101695- (2024)
Summary: Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of simtuzumab (the humanized version of AB0023, a monoclonal
Externí odkaz:
https://doaj.org/article/28bf070de21f4af1b6319da757012509
Autor:
Takeshi Chida, Kazuyoshi Ohta, Hidenao Noritake, Masahiro Matsushita, Gou Murohisa, Fujito Kageyama, Yuzo Sasada, Tatsuki Oyaizu, Minoru Tsugiki, Katsutoshi Tamakoshi, Takeyuki Nakajima, Takafumi Suda, Kazuhito Kawata
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Lysyl oxidase-like 2 (LOXL2) mediates the crosslinking of extracellular collagen, reflecting qualitative changes in liver fibrosis. This study aimed to validate the utility of serum LOXL2 levels as a predictive biomarker for the development
Externí odkaz:
https://doaj.org/article/2bce7fd31c9a4d30a37a2d1e98ff83b9
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-9 (2024)
Abstract Background Ehlers-Danlos syndrome Type IV (aka Vascular Ehlers Danlos, or vEDS) is a dominantly inherited mutation in the Collagen 3A1 gene (COL3A1). The disease is characterized by tissue friability and age-related susceptibility to arteria
Externí odkaz:
https://doaj.org/article/e6712585646e41569fa46571ca3060a7
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Lysyl oxidase-like 2 (LOXL2) is an extracellular copper-dependent enzyme that plays a central role in fibrosis by catalyzing the crosslinking and deposition of collagen. Therapeutic LOXL2 inhibition has been shown to suppress liver fibrosis
Externí odkaz:
https://doaj.org/article/c463a48c9bda4a4f8351f039b4b56c32
Publikováno v:
Journal of Bone Oncology, Vol 44, Iss , Pp 100522- (2024)
The primary function of the lysyl oxidase (LOX) family, including LOX and its paralogue LOX-like (LOXL)-2, is to catalyze the covalent crosslinking of collagen and elastin in the extracellular matrix. LOX and LOXL2 are also facilitating breast cancer
Externí odkaz:
https://doaj.org/article/bfb25f545266488499aaaac6100a6acc
Autor:
Yingmin Liu, Xinya Liu, Fei Chen, Wei Nian, Xiaotong Huang, Qianqian Yang, Songyu Hou, Zhiqin Fan
Publikováno v:
Electronic Journal of Biotechnology, Vol 63, Iss , Pp 18-28 (2023)
Background: Esophageal squamous cell carcinoma is the most common malignant tumor of the upper gastrointestinal tract, which is prone to metastasis and has a poor prognosis. Lysine oxidase-like protein 2 (LOXL2) is an important intracellular protein
Externí odkaz:
https://doaj.org/article/654e54032ade42c4a47524355501d5f3
Akademický článek
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Autor:
Priscila O. de Lima, Natasa Broit, Johnson D. Huang, Jae H. Lim, Damien J. Gardiner, Ian S. Brown, Benedict J. Panizza, Glen M. Boyle, Fiona Simpson
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionCutaneous squamous cell carcinoma of the head and neck (cSCCHN) can metastasize by invading nerves and spread toward the central nervous system. This metastatic process is called perineural invasion (PNI) and spread (PNS). An in vivo scia
Externí odkaz:
https://doaj.org/article/2c5024cdd8094be2929d27f498303ef0