Výsledky vyhledávání - "LOUISE GANNON"

Akademický článek

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity

Autor: Anne-Louise Gannon, Laura O’Hara, Ian J. Mason, Anne Jørgensen, Hanne Frederiksen, Michael Curley, Laura Milne, Sarah Smith, Rod T. Mitchell, Lee B. Smith

Publikováno v: Frontiers in Endocrinology, Vol 11 (2021)

Adrenal androgens are fundamental mediators of ovarian folliculogenesis, embryonic implantation, and breast development. Although adrenal androgen function in target tissues are well characterized, there is little research covering the role of androg

Externí odkaz: https://doaj.org/article/c4afd784fef7443b8606c0d3697100dd

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Akademický článek

Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics

Autor: Saloni H. Patel, Laura O’Hara, Nina Atanassova, Sarah E. Smith, Michael K. Curley, Diane Rebourcet, Annalucia L. Darbey, Anne-Louise Gannon, Richard M. Sharpe, Lee B. Smith

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract The tamoxifen-inducible Cre system is a popular transgenic method for controlling the induction of recombination by Cre at a specific time and in a specific cell type. However, tamoxifen is not an inert inducer of recombination, but an estab

Externí odkaz: https://doaj.org/article/01bc0ff80d6349639fcb5b2646820108

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A Novel Model Using AAV9-Cre to Knockout Adult Leydig Cell Gene Expression Reveals a Physiological Role of Glucocorticoid Receptor Signalling in Leydig Cell Function

Autor: Anne-Louise Gannon, Annalucia L. Darbey, Grace Chensee, Ben M. Lawrence, Liza O’Donnell, Joanna Kelso, Natalie Reed, Shanmathi Parameswaran, Sarah Smith, Lee B. Smith, Diane Rebourcet

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15015

Glucocorticoids are steroids involved in key physiological processes such as development, metabolism, inflammatory and stress responses and are mostly used exogenously as medications to treat various inflammation-based conditions. They act via the gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc39855e09cfcdbfdb87262438e1a202

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The effects of MARIO, a social robot, on the resilience of people with dementia: A multiple case study

Autor: Bárbara Oliveira, Louise Gannon, Tanja Kovacic, Eva Barrett, Megan Burke, Arlene Mannion, Sally Whelan, Dympna Casey, Edel Shiel, Adam Santorelli

Background: Resilience is a process of adapting to stress. For people with dementia, resilience is enhanced through having positive social relationships. Social robots, such as MARIO, can facilitate social engagement. However, the effect of social ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3926ffd1ae63a9c105c75009fdeb2897
http://hdl.handle.net/10379/16199

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Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing

Autor: Laura Milne, Rod T. Mitchell, Lee B. Smith, Anne Jørgensen, Sarah Smith, Hanne Frederiksen, Anne-Louise Gannon, J. Ian Mason, Laura O’Hara

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Gannon, A, O’hara, L, Mason, J I, Jørgensen, A, Frederiksen, H, Milne, L, Smith, S, Mitchell, R T & Smith, L B 2019, ' Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing ', Scientific Reports, vol. 9, no. 1 . https://doi.org/10.1038/s41598-019-46049-3

Androgens are known to be an essential regulator of male health. Androgen receptor (AR) is widely expressed throughout the adrenal cortex, yet the wider role for androgen signalling in the adrenal remains underexplored. To investigate AR-dependent an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c694804b0a2d8ba9efc0c3616f67c5b0
https://doi.org/10.1038/s41598-019-46049-3

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Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders

Autor: Anne Jørgensen, Adriana Traveres, Hanne Frederiksen, Lee B. Smith, Anne-Louise Gannon, Carlos J. Alcaide-Corral, Sarah Smith, Rod T. Mitchell, J. Ian Mason, Diane Rebourcet, Laura O’Hara, Laura Milne

Publikováno v: Gannon, A, O'Hara, L, Mason, I, Rebourcet, D, Smith, S, Tavares, A, Corral, C A, Frederiksen, H, Jorgensen, A, Mitchell, R T & Smith, L B 2019, ' Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders ', Scientific Reports, vol. 9, 3250 . https://doi.org/10.1038/s41598-019-39867-y
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)

The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff0de89f23c9d36c27a80e14c4d8513
https://hdl.handle.net/20.500.11820/0b8861b2-8ae0-46af-9e01-8f970194f193

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Elektronická kniha

Brutally Honest : The Sunday Times Bestseller

Autor: Melanie Brown, Louise Gannon

'Utterly absorbing and deeply affecting'– The GuardianAs a Spice Girl, TV talent show judge and Broadway star, Mel B a.k.a Scary Spice, has been a global icon since her twenties. But behind the glittering façade of fame, the struggles and pain of

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