Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen

Autor: Thomas A. Bunch, Piyali Guhathakurta, Andrew R. Thompson, Brett A. Colson, David D. Thomas, Victoria C. Lepak, Rhye Samuel Kanassatega, Anna Wilson

Publikováno v: The Journal of Biological Chemistry

Cardiac myosin-binding protein C (cMyBP-C) interacts with actin and myosin to modulate cardiac muscle contractility. These interactions are disfavored by cMyBP-C phosphorylation. Heart failure patients often display decreased cMyBP-C phosphorylation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e8b63a383fc7d22dea35788b29aa60
https://pubmed.ncbi.nlm.nih.gov/34052227

Identification of signalling cascades involved in red blood cell shrinkage and vesiculation

Autor: Timo K. van den Berg, Elena Kostova, Robin van Bruggen, Pasi Halonen, Thomas R. L. Klei, Boukje M. Beuger, Cor Lieftink, Roderick L. Beijersbergen

Publikováno v: Bioscience Reports
Bioscience Reports, Vol 35, Iss 2, p e00187 (2015)
Kostova, E B, Beuger, B M, Klei, T R L, Halonen, P, Lieftink, C, Beijersbergen, R, van den Berg, T K & van Bruggen, R 2015, ' Identification of signalling cascades involved in red blood cell shrinkage and vesiculation ', Frontiers in Bioscience, vol. 35, no. 2 . https://doi.org/10.1042/BSR20150019
Frontiers in Bioscience, 35(2). Frontiers in Bioscience
Bioscience reports, 35(2). Portland Press Ltd.

Even though red blood cell (RBC) vesiculation is a well-documented phenomenon, notably in the context of RBC aging and blood transfusion, the exact signalling pathways and kinases involved in this process remain largely unknown. We have established a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7eaf893b837cb3d5e683e1beaee15c2
https://pubmed.ncbi.nlm.nih.gov/25757360