Zobrazeno 1 - 10
of 59
pro vyhledávání: '"LOH, loss of heterozygosity"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
The incidence of esophageal adenocarcinoma (EAC) and other gastrointestinal (GI) cancers have risen dramatically, thus defining the oncogenic drivers to develop effective therapies are necessary. Patients with Barrett's Esophagus (BE), have an elevat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb8b4a5877a31843d9d41138bf96cb2
https://doi.org/10.1016/j.jcmgh.2020.10.012
https://doi.org/10.1016/j.jcmgh.2020.10.012
Autor:
Seyedeh Maryam Kazemi, Aghil Esmaieli-bandboni, Ziba Veisi Malekshahi, Mohammad Shahbaz Sardood, Mehrdad Hashemi, Keivan Majidzadeh, Maryam Kadkhodazadeh, Rezvan Esmaili, Babak Negahdari
Publikováno v:
Annals of Medicine and Surgery
Objectives Vitamin D deficiency is a driving force of common cancers like breast cancer. Vitamin D receptor (VDR) can play a tumor suppressor role by helping the precise function of vitamin D in cells such as modulation TGF-β signaling pathway. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ebba11afdbd36734c3bae434ef5c8f
http://europepmc.org/articles/PMC8666522
http://europepmc.org/articles/PMC8666522
Autor:
Arefi, Majid, Wilson, Valerie, Muthiah, Siobhan, Zwolinski, Simon, Bajwa, Dalvir, Brennan, Paul, Blasdale, Katie, Bourn, David, Burn, John, Santibanez-Koref, Mauro, Rajan, Neil
Publikováno v:
Journal of the American Academy of Dermatology
Background Clusters of rare cylindroma or spiradenoma tumors are a recurrent clinical presentation, yet conventional genetic testing results in individuals with these tumors are frequently normal. Objective To determine if genetic mosaicism accounts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b18a6c1665ff2356744a9d2bc176f11
http://europepmc.org/articles/PMC6878220
http://europepmc.org/articles/PMC6878220
Autor:
Yasuhiko Kaneko, Takehiko Kamijo, Tsugumichi Koshinaga, Yukichi Tanaka, Masahiro Fukuzawa, Masayuki Haruta, Takaharu Oue, Yasuhito Arai, Tetsuya Takimoto, Ryuichi P. Sugino, Yasuhiro Yamada, Hajime Okita
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 1, Pp 117-131 (2019)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
To identify prognostic factors, array CGH (aCGH) patterns and mutations in WT1 and 9 other genes were analyzed in 128 unilateral Wilms tumors (WTs). Twenty patients had no aCGH aberrations, and 31 had WT1 alterations [silent and WT1 types: relapse-fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69968604674dc535303648f3492b04e
http://www.sciencedirect.com/science/article/pii/S1476558618304147
http://www.sciencedirect.com/science/article/pii/S1476558618304147
Publikováno v:
JAAD Case Reports
JAAD Case Reports, Vol 9, Iss, Pp 102-104 (2021)
JAAD Case Reports, Vol 9, Iss, Pp 102-104 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf151506e767219f6206f2fc60842a1c
https://pubmed.ncbi.nlm.nih.gov/33681440
https://pubmed.ncbi.nlm.nih.gov/33681440
Autor:
John T. Seykora, Matthew L. Hedberg
Publikováno v:
The Journal of Investigative Dermatology
Actinic keratoses (AKs) are lesions of epidermal keratinocyte dysplasia and are precursors for invasive cutaneous squamous cell carcinoma (cSCC). Identifying the specific genomic alterations driving the progression from normal skin to skin with AK to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c1999991b1fd1a9ce02856cf8a0f25
https://pubmed.ncbi.nlm.nih.gov/33482222
https://pubmed.ncbi.nlm.nih.gov/33482222
Autor:
Jia-Tao Zhang, Jian Su, Hai-Yan Tu, Hao Sun, Xu-Chao Zhang, Zhi-Hong Chen, Jin-Ji Yang, Qing Zhou, Yi-Long Wu, Jia-Ying Zhou, Si-Yang Maggie Liu, Kai Yin
Publikováno v:
Translational Oncology
Translational Oncology, Vol 15, Iss 1, Pp 101254-(2022)
Translational Oncology, Vol 15, Iss 1, Pp 101254-(2022)
Highlights • Predictive power of PD response for ICIs was superior than traditional biomarkers; • Predictive efficacy was improved by integrating tumor-immune-related features; • When tumor-specific feature was replaced, the model has pan-cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daad381fb5c7640d53e71e4388f09e65
https://doi.org/10.1016/j.tranon.2021.101254
https://doi.org/10.1016/j.tranon.2021.101254
Autor:
David Wenkert, Xin Shen, Fengfei Wang, Eric T. Wong, Zheng Zheng, Dan Qi, Erxi Wu, Shuang Zhou, Ekokobe Fonkem, Batool F. Kirmani, Jason H. Huang, Fushun Wang, Jitian Guan, Touradj Solouki
Publikováno v:
EBioMedicine
Background Glioblastoma multiforme (GBM) is a fatal disease without effective therapy. Identification of new biomarkers for prognosis would enable more rational selections of strategies to cure patients with GBM and prevent disease relapse. Methods S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08dfdc58033eb0b4f7314556097305bd
https://doi.org/10.1016/j.ebiom.2018.10.024
https://doi.org/10.1016/j.ebiom.2018.10.024
Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma1
Publikováno v:
Neoplasia (New York, N.Y.)
A majority of cases of high-risk neuroblastoma, an embryonal childhood cancer, are driven by MYC or MYCN-driven oncogenic signaling. While considered to be directly "undruggable" therapeutically, MYC and MYCN can be repressed transcriptionally by inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb66eb6c80701d92c4fe65e2f0efe021
http://europepmc.org/articles/PMC6111011
http://europepmc.org/articles/PMC6111011
Autor:
Shah, Seema, Brock, Ethan J., Jackson, Ryan M., Ji, Kyungmin, Boerner, Julie L., Sloane, Bonnie F., Mattingly, Raymond R.
Publikováno v:
Neoplasia (New York, N.Y.)
Diagnosis of breast ductal carcinoma in situ (DCIS) presents a challenge since we cannot yet distinguish those cases that would remain indolent and not require aggressive treatment from cases that may progress to invasive ductal cancer (IDC). The pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8109f7cc0b354221a67fbb885d910687
http://europepmc.org/articles/PMC6106701
http://europepmc.org/articles/PMC6106701