miR-125a-5p Functions as Tumor Suppressor microRNA And Is a Marker of Locoregional Recurrence And Poor prognosis in Head And Neck Cancer1

Autor: Vo, Dat T., Karanam, Narasimha Kumar, Ding, Lianghao, Saha, Debabrata, Yordy, John S., Giri, Uma, Heymach, John V., Story, Michael D.

Publikováno v: Neoplasia (New York, N.Y.)

MicroRNAs (miRNAs) are short single-stranded RNAs, measuring 21 to 23 nucleotides in length and regulate gene expression at the post-transcriptional level through mRNA destabilization or repressing protein synthesis. Dysregulation of miRNAs can lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65e42cbfcc3be79653e0b382f66f3a0f
http://europepmc.org/articles/PMC6642270

A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives

Autor: Xiangyu Wang, An Lu, Qiang Zhang, Zakia Belhadj, Yujie Shi, Jiancheng Wang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2396-2415 (2021)

The need for long-term treatments of chronic diseases has motivated the widespread development of long-acting parenteral formulations (LAPFs) with the aim of improving drug pharmacokinetics and therapeutic efficacy. LAPFs have been proven to extend t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ae988908ab95b495e6190ff9a49114
https://pubmed.ncbi.nlm.nih.gov/34522592

Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner

Autor: Natasza A. Kurpios, Jason R. Spence, Bailey C.E. Peck, Oyebola O. Oyesola, Shengli Ding, Alessandro Bonfini, Christopher M. Dekaney, John M. Freund, Liara M. Gonzalez, Elia D. Tait-Wojno, Ennessa G. Curry, Ajeet Singh, Yu-Han Hung, Gavin A. Bewick, Nicolas Buchon, Praveen Sethupathy, Mandy Biraud, Michael J. Shanahan, Michael K. Dame, Rebecca L. Cubitt, Matt Kanke

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 447-464 (2020)

Background & Aims The enteroendocrine cell (EEC) lineage is important for intestinal homeostasis. It was recently shown that EEC progenitors contribute to intestinal epithelial growth and renewal, but the underlying mechanisms remain poorly understoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d648ac5f82b44a6f7ba154f7147f74a3
https://pubmed.ncbi.nlm.nih.gov/31756561

Broadly targeted multiprobe QPCR for detection of coronaviruses: Coronavirus is common among mallard ducks (Anas platyrhynchos)

Autor: Jonas Blomberg, Shaman Muradrasoli, Jan Fohlman, Ákos Hornyák, Sándor Belák, Nahla Mohamed, Bjorn R. Olsen

Publikováno v: Journal of Virological Methods

Coronaviruses (CoVs) can cause trivial or fatal disease in humans and in animals. Detection methods for a wide range of CoVs are needed, to understand viral evolution, host range, transmission and maintenance in reservoirs. A new concept, “Multipro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de2da658c184dc795ef8ed962b7a54a
http://europepmc.org/articles/PMC7112901

Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs

Autor: Marikki Laiho, Baoyan Bai, Hester Liu

Publikováno v: FEBS Open Bio
FEBS Open Bio, Vol 4, Iss C, Pp 441-449 (2014)

Highlights • miRNA expression arrays and RNA Seq were employed for unbiased spatial analyses of miRNAs. • Small RNomics of subcellular compartments revealed the presence of miRNAs in the nucleolus. • Several miRNAs were detected at low abundanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222ff55451cb9016a5ddf595c0cfe0ce
https://pubmed.ncbi.nlm.nih.gov/24918059