Improving NK-cell immunotherapy against rhabdomyosarcoma

Autor: LM Reindl, V Grèze, P Wendel, V Särchen, WS Wels, M Vogler, E Ullrich

Publikováno v: Klinische Pädiatrie.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e01fdd75dc1f46813eb5d1d2641535c5
https://doi.org/10.1055/s-0042-1748746

Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors.

Autor: Bexte T; Goethe University, Department of Pediatrics, Experimental Immunology and Cell Therapy, Frankfurt am Main, Germany; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany; University Cancer Center (UCT) Frankfurt, Frankfurt, Germany; Mildred Scheel Career Center (MSNZ), Hospital of the Goethe University Frankfurt, Frankfurt, Germany; Institute for Transfusion Medicine and Immunohematology, German Red Cross Blood Service Baden-Württemberg - Hesse, Frankfurt, Germany., Botezatu L; Research Centre, Division of Hematology, Gene and Cell Therapy, Paul-Ehrlich-Institut, Langen, Germany; German Cancer Consortium (DKTK), partner site Heidelberg, Heidelberg, Germany., Miskey C; Research Centre, Division of Hematology, Gene and Cell Therapy, Paul-Ehrlich-Institut, Langen, Germany., Gierschek F; Goethe University, Department of Pediatrics, Experimental Immunology and Cell Therapy, Frankfurt am Main, Germany; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany., Moter A; Goethe University, Department of Pediatrics, Experimental Immunology and Cell Therapy, Frankfurt am Main, Germany; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany., Wendel P; Goethe University, Department of Pediatrics, Experimental Immunology and Cell Therapy, Frankfurt am Main, Germany; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany., Reindl LM; Goethe University, Department of Pediatrics, Experimental Immunology and Cell Therapy, Frankfurt am Main, Germany; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany., Campe J; Goethe University, Department of Pediatrics, Experimental Immunology and Cell Therapy, Frankfurt am Main, Germany; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany., Villena-Ossa JF; Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany; Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany., Gebel V; Goethe University, Department of Pediatrics, Experimental Immunology and Cell Therapy, Frankfurt am Main, Germany; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany; University Cancer Center (UCT) Frankfurt, Frankfurt, Germany; Mildred Scheel Career Center (MSNZ), Hospital of the Goethe University Frankfurt, Frankfurt, Germany., Stein K; Goethe University, Department of Pediatrics, Experimental Immunology and Cell Therapy, Frankfurt am Main, Germany; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany; University Cancer Center (UCT) Frankfurt, Frankfurt, Germany., Cathomen T; Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany; Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), partner site Freiburg, Freiburg, Germany., Cremer A; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany; University Cancer Center (UCT) Frankfurt, Frankfurt, Germany; Mildred Scheel Career Center (MSNZ), Hospital of the Goethe University Frankfurt, Frankfurt, Germany; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Hematology/Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany., Wels WS; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany., Hudecek M; Department of Medicine II, Chaire in Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany; Fraunhofer Institute for Cell Therapy and Immunology, Cellular Immunotherapy Branch Site Würzburg, Würzburg, Germany., Ivics Z; Research Centre, Division of Hematology, Gene and Cell Therapy, Paul-Ehrlich-Institut, Langen, Germany; German Cancer Consortium (DKTK), partner site Heidelberg, Heidelberg, Germany., Ullrich E; Goethe University, Department of Pediatrics, Experimental Immunology and Cell Therapy, Frankfurt am Main, Germany; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany; University Cancer Center (UCT) Frankfurt, Frankfurt, Germany; Mildred Scheel Career Center (MSNZ), Hospital of the Goethe University Frankfurt, Frankfurt, Germany; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: evelyn@ullrichlab.de.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Jul 03; Vol. 32 (7), pp. 2357-2372. Date of Electronic Publication: 2024 May 14.

Nonviral technologies can pave the way for CAR-NK cell therapy.

Autor: Bexte T; Goethe University Frankfurt, Department of Pediatrics, Experimental Immunology & Cell Therapy, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Paul-Ehrlich-Straße 42-44, 60596 Frankfurt am Main, Germany.; University Cancer Center (UCT), Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.; Mildred Scheel Career Center (MSNZ), Hospital of the Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Reindl LM; Goethe University Frankfurt, Department of Pediatrics, Experimental Immunology & Cell Therapy, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Paul-Ehrlich-Straße 42-44, 60596 Frankfurt am Main, Germany., Ullrich E; Goethe University Frankfurt, Department of Pediatrics, Experimental Immunology & Cell Therapy, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Paul-Ehrlich-Straße 42-44, 60596 Frankfurt am Main, Germany.; University Cancer Center (UCT), Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.; Mildred Scheel Career Center (MSNZ), Hospital of the Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) partner site Frankfurt/Mainz; Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2023 Oct 26; Vol. 114 (5), pp. 475-486.

Characterization of BV6-Induced Sensitization to the NK Cell Killing of Pediatric Rhabdomyosarcoma Spheroids.

Autor: Särchen V; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, 60528 Frankfurt, Germany., Reindl LM; Department for Children and Adolescents Medicine, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt, Germany.; Experimental Immunology, Goethe-University, 60590 Frankfurt, Germany., Wiedemann S; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, 60528 Frankfurt, Germany., Shanmugalingam S; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, 60528 Frankfurt, Germany., Bukur T; TRON gGmbH-Translational Oncology, The University Medical Center, The Johannes Gutenberg-University Mainz, 55131 Mainz, Germany., Becker J; TRON gGmbH-Translational Oncology, The University Medical Center, The Johannes Gutenberg-University Mainz, 55131 Mainz, Germany., Suchan M; TRON gGmbH-Translational Oncology, The University Medical Center, The Johannes Gutenberg-University Mainz, 55131 Mainz, Germany., Ullrich E; Department for Children and Adolescents Medicine, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt, Germany.; Experimental Immunology, Goethe-University, 60590 Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Mainz/Frankfurt, 69120 Heidelberg, Germany.; University Cancer Center Frankfurt (UCT), University Hospital Frankfurt, Goethe-University Frankfurt, 60590 Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe-University, 60590 Frankfurt, Germany., Vogler M; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, 60528 Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Mainz/Frankfurt, 69120 Heidelberg, Germany.

Publikováno v: Cells [Cells] 2023 Mar 15; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 15.

Frequency Comb-Based Ground-Penetrating Bioradar: System Implementation and Signal Processing.

Autor: Shi D; Laboratory for Electrical Instrumentation and Embedded Systems, Department of Microsystems Engineering-IMTEK, University of Freiburg, Georges-Köhler-Allee 106, 79110 Freiburg, Germany., Gidion G; Laboratory for Electrical Instrumentation and Embedded Systems, Department of Microsystems Engineering-IMTEK, University of Freiburg, Georges-Köhler-Allee 106, 79110 Freiburg, Germany., Aftab T; Laboratory for Electrical Instrumentation and Embedded Systems, Department of Microsystems Engineering-IMTEK, University of Freiburg, Georges-Köhler-Allee 106, 79110 Freiburg, Germany., Reindl LM; Laboratory for Electrical Instrumentation and Embedded Systems, Department of Microsystems Engineering-IMTEK, University of Freiburg, Georges-Köhler-Allee 106, 79110 Freiburg, Germany., Rupitsch SJ; Laboratory for Electrical Instrumentation and Embedded Systems, Department of Microsystems Engineering-IMTEK, University of Freiburg, Georges-Köhler-Allee 106, 79110 Freiburg, Germany.

Publikováno v: Sensors (Basel, Switzerland) [Sensors (Basel)] 2023 Jan 25; Vol. 23 (3). Date of Electronic Publication: 2023 Jan 25.