Výsledky vyhledávání - "LLOQ, lower limit of quantification"

Listening to your mass spectrometer: An open-source toolkit to visualize mass spectrometer data

Autor: Abed, Pablo, Andrew N, Hoofnagle, Patrick C, Mathias

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 23, Iss, Pp 44-49 (2022)
Journal of Mass Spectrometry and Advances in the Clinical Lab

Highlights • Mass spectrometry produces data which can be used to monitor instrument performance. • We describe a tool that parses and visualizes mass spectrometry data. • This toolkit can be applied to increase quality control for a complex LC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3da7bc2257c15592067041befb1804
https://doi.org/10.1016/j.jmsacl.2021.12.003

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Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy

Autor: Zhuowei Liu, Yuxi Wang, Chengjian Zhao, Yang Zhang, Manyu Zhao, Jinliang Yang, Yuqin Yao, Peng Li, Chen Zhengxia, Xiaoxin Chen, Chaofeng Long

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1453-1475 (2020)

Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6380c470a4be26e380966eab21f579
http://europepmc.org/articles/PMC7488503

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Poloxamer-chitosan-based Naringenin nanoformulation used in brain targeting for the treatment of cerebral ischemia

Autor: Aftab Alam, Abuzer Ali, Mohd Amir, Farhan Jalees Ahmad, Wasim Ahmad, Niyaz Ahmad, Rizwan Ahmad

Publikováno v: Saudi Journal of Biological Sciences, Vol 27, Iss 1, Pp 500-517 (2020)
Saudi Journal of Biological Sciences

Graphical abstract
Objective Here, the aim is to improve the bioavailability of Naringenin (NRG) in brain and to establish the highest remedial benefit from a novel anti-ischemic medicine i.e. NRG. Methods A novel Naringenin-loaded-nanoemulsion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbf9305501d6bea3502fb47e997e300
http://www.sciencedirect.com/science/article/pii/S1319562X19302402

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A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis

Autor: Cecilie L. Bager, Morten A. Karsdal, Bidisha Dasgupta, Carrie Brodmerkel, Mark Curran, Nicholas Willumsen, Jannie M.B. Sand, D.J. Leeming, S Holm Nielsen

Publikováno v: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 17, Iss, Pp 38-43 (2019)

Objectives: Lysyl oxidase like 2 (LOXL2) is associated with poor prognosis in idiopathic pulmonary disease (IPF) and cancer. We developed an Enzyme-linked immunosorbent assay (ELISA) targeting the LOXL2 neo-epitope generated through the release of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0546bda8f6758ecfa70211c7cf338d5
https://doi.org/10.1016/j.bbrep.2018.11.002

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Long-term immunogenicity and safety of a non-typeable

Autor: Philippe, De Smedt, Geert, Leroux-Roels, Corinne, Vandermeulen, Annaelisa, Tasciotti, Gennaro, Di Maro, Marie, Dozot, Daniela, Casula, Margherita, Annaratone, Daniele, Riccucci, Ashwani Kumar, Arora

Publikováno v: Vaccine: X

Highlights • Older adults with smoking history received two doses of combined NTHi-Mcat vaccine. • We evaluated antibody persistence during 4 years of follow-up after vaccination. • Immune responses against the NTHi protein antigens persisted u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e780eed6e1225a31a9b921e2a3c41891
https://pubmed.ncbi.nlm.nih.gov/34820619

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Proximity Extension Assay in Combination with Next-Generation Sequencing for High-throughput Proteome-wide Analysis

Autor: Sara Henriksson, John Broberg, Lotta Wik, Ida Grundberg, Martin Lundberg, Erika Assarsson, Niklas Nordberg, Erik Pettersson, Elin Liljeroth, Adam Falck, Johan Björkesten, Christina Westerberg

Publikováno v: Molecular & Cellular Proteomics : MCP

Understanding the dynamics of the human proteome is crucial for developing biomarkers to be used as measurable indicators for disease severity and progression, patient stratification, and drug development. The Proximity Extension Assay (PEA) is a tec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b38932b76beb2a83e8270e33800cffe
https://pubmed.ncbi.nlm.nih.gov/34715355

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Chronic hepatitis D associated with worse patient-reported outcomes than chronic hepatitis B

Autor: Rafael Esteban, Zobair M. Younossi, Adriana Palom, Luisa Roade, Mar Riveiro-Barciela, Fatema Nader, Maria Buti, Maria Stepanova

Publikováno v: JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100280-(2021)
JHEP Rep
Scientia
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Background & Aims Health-related quality of life (HRQoL) determined by patient-reported outcomes (PROs) is impaired in chronic hepatitis B (CHB) and C patients, but there are no data regarding patients with chronic hepatitis D (CHD). The aim of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4227ac6bd8a683276690102ac5f584b0
https://ddd.uab.cat/record/241075

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Pharmacokinetics of the SABRE agent 4,6-d2-nicotinamide and also nicotinamide in rats following oral and intravenous administration

Autor: Linnik, Inna V., Rayner, Peter J., Stow, Ruth A., Duckett, Simon B., Cheetham, Graham M.T.

Publikováno v: European Journal of Pharmaceutical Sciences

To prepare the way for using the isotopically labelled SABRE hyperpolarized 4,6-d2-nicotinamide as an MRI agent in humans we have performed an in-vivo study to measure its pharmacokinetics in the plasma of healthy rats after intravenous and oral admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee68f7c2b28c1c0f9184a32ba358fa63
http://europepmc.org/articles/PMC6556870

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Cross-platform comparison of highly sensitive immunoassay technologies for cytokine markers: Platform performance in post-traumatic stress disorder and Parkinson’s disease

Autor: Allison C. Provost, Andreas Jeromin, Nikolaos P. Daskalakis, Lauren E. Chaby, Heather Lasseter, Magali Haas

Publikováno v: Cytokine
Cytokine: X, Vol 2, Iss 2, Pp 100027-(2020)

Highlights • Cross-platform comparisons were conducted across five leading immunoassay platforms. • Plasma and serum were obtained from healthy controls and clinical populations. • Analytic parameters included sensitivity, precision, and perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290352d998ae54423228c23c650bc1fb
http://europepmc.org/articles/PMC7885879

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Impact of chemical modification of sulfamidase on distribution to brain interstitial fluid and to CSF after an intravenous administration in awake, freely-moving rats

Autor: Joost H.A. Folgering, Maria Eriksson, Lars Bergquist, Gudrun Andersson, Juliette Janson

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 22, Iss, Pp-(2020)
Molecular Genetics and Metabolism Reports

Mucopolysaccharidosis III A (MPS IIIA) is an autosomal recessive lysosomal storage disorder caused by deficiency of the enzyme sulfamidase. The disorder results in accumulation of heparan sulfate, lysosomal enlargement and cellular and organ dysfunct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5926859a8eba56927ab317fa4978ed
http://www.sciencedirect.com/science/article/pii/S221442691930196X

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