Zobrazeno 1 - 10
of 98
pro vyhledávání: '"LIVIA MANZELLA"'
Autor:
Maria Stella Pennisi, Sandra Di Gregorio, Elena Tirrò, Chiara Romano, Andrea Duminuco, Bruno Garibaldi, Gaetano Giuffrida, Livia Manzella, Paolo Vigneri, Giuseppe A. Palumbo
Publikováno v:
Hematology Reports, Vol 15, Iss 2, Pp 317-324 (2023)
Essential thrombocythemia (ET) and primary myelofibrosis (PMF) are two of the main BCR-ABL1-negative chronic myeloproliferative neoplasms (MPNs) characterized by abnormal megakaryocytic proliferation. Janus kinase 2 (JAK2) mutations are detected in 5
Externí odkaz:
https://doaj.org/article/0f2895a965554aea8fd58e369039bcf1
Autor:
Stefania Stella, Michele Massimino, Livia Manzella, Nunziatina Laura Parrinello, Silvia Rita Vitale, Federica Martorana, Paolo Vigneri
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionBreast cancer is the most common malignancy in women, and it is linked to several risk factors including genetic alterations, obesity, estrogen signaling, insulin levels, and glucose metabolism deregulation. Insulin and Insulin-like growt
Externí odkaz:
https://doaj.org/article/dc52719f7bae45e6b29b79f0b3dd9004
Autor:
Elena Tirrò, Michele Massimino, Giuseppe Broggi, Chiara Romano, Simone Minasi, Francesca Gianno, Manila Antonelli, Gianmarco Motta, Francesco Certo, Roberto Altieri, Livia Manzella, Rosario Caltabiano, Giuseppe Maria Vincenzo Barbagallo, Francesca Romana Buttarelli, Gaetano Magro, Felice Giangaspero, Paolo Vigneri
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The management of patients with Central Nervous System (CNS) malignancies relies on the appropriate classification of these tumors. Recently, the World Health Organization (WHO) has published new criteria underlining the importance of an accurate mol
Externí odkaz:
https://doaj.org/article/8b4a7086a7bf44bdb5b01f6967f63c5b
Publikováno v:
Translational Oncology, Vol 14, Iss 8, Pp 101104- (2021)
Over the last quarter century several genetic alterations have been implicated in hereditary breast cancer (HBC). Two papers recently published in the New England Journal of Medicine explored the mutation prevalence in breast cancer predisposition ge
Externí odkaz:
https://doaj.org/article/f1389bd706d04c2ea47abf5ddfd7918c
Autor:
Michele Massimino, Elena Tirrò, Stefania Stella, Livia Manzella, Maria Stella Pennisi, Chiara Romano, Silvia Rita Vitale, Adriana Puma, Cristina Tomarchio, Sandra Di Gregorio, Agostino Antolino, Francesco Di Raimondo, Paolo Vigneri
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Chronic Myeloid Leukemia (CML) is a hematological disorder characterized by the clonal expansion of a hematopoietic stem cell carrying the Philadelphia chromosome that juxtaposes the BCR and ABL1 genes. The ensuing BCR-ABL1 chimeric oncogene is chara
Externí odkaz:
https://doaj.org/article/e64984d411ed458d9ee29e056ad88a5f
Autor:
Federica Martorana, Gianmarco Motta, Giuliana Pavone, Lucia Motta, Stefania Stella, Silvia Rita Vitale, Livia Manzella, Paolo Vigneri
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The serine/threonine kinase AKT is a key component of the PI3K/AKT/mTOR signaling pathway as it exerts a pivotal role in cell growth, proliferation, survival, and metabolism. Deregulation of this pathway is a common event in breast cancer including h
Externí odkaz:
https://doaj.org/article/3e62123234b6441682d4dde9eb7d7a0b
Autor:
Elena Tirrò, Michele Massimino, Chiara Romano, Federica Martorana, Maria Stella Pennisi, Stefania Stella, Giuliana Pavone, Sandra Di Gregorio, Adriana Puma, Cristina Tomarchio, Silvia Rita Vitale, Livia Manzella, Paolo Vigneri
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Glioblastoma multiforme (GBM) is the most common primary brain malignancy and is often resistant to conventional treatments due to its extensive cellular heterogeneity. Thus, the overall survival of GBM patients remains extremely poor. Insulin-like g
Externí odkaz:
https://doaj.org/article/5b3b2a650bd34cddbfe18451893beb66
Autor:
Stefania Stella, Silvia Rita Vitale, Fabio Stagno, Michele Massimino, Adriana Puma, Cristina Tomarchio, Maria Stella Pennisi, Elena Tirrò, Chiara Romano, Francesco Di Raimondo, Emma Cacciola, Rossella Cacciola, Livia Manzella
Publikováno v:
Diagnostics, Vol 12, Iss 5, p 1051 (2022)
Background: Detection of BCR-ABL1 transcript level via real-time quantitative-polymerase-chain reaction (Q-PCR) is a clinical routine for disease monitoring, assessing Tyrosine Kinase Inhibitor therapy efficacy and predicting long-term response in ch
Externí odkaz:
https://doaj.org/article/f7d7cb5661ca4f51a9017dfe1bdc1026
Autor:
Veronica Vella, Ernestina Marianna De Francesco, Rosamaria Lappano, Maria Grazia Muoio, Livia Manzella, Marcello Maggiolini, Antonino Belfiore
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The development and progression of the great majority of breast cancers (BCs) are mainly dependent on the biological action elicited by estrogens through the classical estrogen receptor (ER), as well as the alternate receptor named G-protein–couple
Externí odkaz:
https://doaj.org/article/fdd2ec289a3a49d385de59116e6c9588
Autor:
Michele Massimino, Stefania Stella, Elena Tirrò, Chiara Romano, Maria Stella Pennisi, Adriana Puma, Livia Manzella, Antonino Zanghì, Fabio Stagno, Francesco Di Raimondo, Paolo Vigneri
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-15 (2018)
Abstract The introduction of ABL Tyrosine Kinase Inhibitors (TKIs) has significantly improved the outcome of Chronic Myeloid Leukemia (CML) patients that, in large part, achieve satisfactory hematological, cytogenetic and molecular remissions. Howeve
Externí odkaz:
https://doaj.org/article/9b21a4b502ea48ec89c59850edc2e6d1