Zobrazeno 1 - 8
of 8
pro vyhledávání: '"LISA BEEBE"'
Autor:
Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael Ellis
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in m
Externí odkaz:
https://doaj.org/article/c77d178e9fdf4a27bb6fc2263243c22d
Autor:
Ellen H. Filvaroff, Gordon L. Bray, Konstantinos Mavrommatis, Tao Shi, Winfried Elis, Mehnaz Malek, Lisa Beebe, Lixin Qiao, Terri Jones, Carmen Barnes, Matt Labenski, Yumin Dai, Ida Aronchik
Supplementary figure legends and supplementary materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4adb15c082041175df0f7d43940ae6e3
https://doi.org/10.1158/1541-7786.22512627
https://doi.org/10.1158/1541-7786.22512627
Autor:
Ellen H. Filvaroff, Gordon L. Bray, Konstantinos Mavrommatis, Tao Shi, Winfried Elis, Mehnaz Malek, Lisa Beebe, Lixin Qiao, Terri Jones, Carmen Barnes, Matt Labenski, Yumin Dai, Ida Aronchik
Table S1. Summary of CC-90003 specificity data resulting from cellular and biochemical assays. Table S2. Response of BRAF mutant cell lines to CC-90003 ERK 1/2 inhibition. Table S3. Summary of dose finding efficacy study in HCT-116 xenograft model. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e849dfd569bc7b70d64cf4940b8fb52e
https://doi.org/10.1158/1541-7786.22512630.v1
https://doi.org/10.1158/1541-7786.22512630.v1
Autor:
Ellen H. Filvaroff, Gordon L. Bray, Konstantinos Mavrommatis, Tao Shi, Winfried Elis, Mehnaz Malek, Lisa Beebe, Lixin Qiao, Terri Jones, Carmen Barnes, Matt Labenski, Yumin Dai, Ida Aronchik
As a critical signaling node, ERK1/2 are attractive drug targets, particularly in tumors driven by activation of the MAPK pathway. Utility of targeting the MAPK pathway has been demonstrated by clinical responses to inhibitors of MEK1/2 or RAF kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70b18390d917894d488d4b1a96711e9d
https://doi.org/10.1158/1541-7786.c.6540297.v1
https://doi.org/10.1158/1541-7786.c.6540297.v1
Autor:
JOHN Malona, CLAUDIO CHUAQUI, BORIS M. SELETSKY, LISA BEEBE, SUSAN CANTIN, DANIEL VAN KALKEN, KELLY FAHNOE, ZHIGANG WANG, BETH BROWNING, HILARY SZABO, LOUISE A. KOOPMAN, TAMAS ORAVECZ, JOSEPH J. MCDONALD, FRANCISCO RAMIREZ-VALLE, RAJULA GAUR, KOFI A. MENSAH, MICHAEL THOMAS, JAMIE N. CONNARN, HAIQING HU, MATTHEW D. ALEXANDER, ALAN F. CORIN
Publikováno v:
Translational research : the journal of laboratory and clinical medicine. 249
As an anti-inflammatory strategy, MAPK-activated protein kinase-2 (MK2) inhibition can potentially avoid the clinical failures seen for direct p38 inhibitors, especially tachyphylaxis. CC-99677, a selective targeted covalent MK2 inhibitor, employs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6afca613da09ae7ab956e9811531b01
https://pubmed.ncbi.nlm.nih.gov/35691544
https://pubmed.ncbi.nlm.nih.gov/35691544
Autor:
Shivsmriti Koul, John Malona, Lisa Beebe, Laure Escoubet, Meghan Clements, Arvind Shakya, Veerabahu Shanmugasundaram, Lan Jiang, Lawrence G. Hamann, Matt M. Kreilein, Jenna Malley, C. Eric Schwartz, Roman Shimanovich, Ganesh Rajaraman, Alex Dubrovskiy, Laura Akullian D’Agostino, Justin Stedman, Andrea Local, J. Michael Ellis, Tiffany Carr, Steven A. Saenz, Haiqing Hu, John Cho, Lisa Chourb
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0248034 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0248034 (2021)
PLoS ONE
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fdb7715b2c933851e25206e28f0210
https://doi.org/10.1101/2021.02.19.431952
https://doi.org/10.1101/2021.02.19.431952
Publikováno v:
Bioanalysis. 3:487-498
Background: Combination biologic therapy is an emerging area of clinical development and the physiological and analytical impact of one treatment on the other requires careful assessment. Significant analytical challenges are associated with developi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83399abbbe315f1435c6b0fe1a7fd7bd
https://doi.org/10.4155/bio.10.214
https://doi.org/10.4155/bio.10.214
Autor:
Gordon Moody, Oxana K. Pickeral, Marta Corcoran, Lisa Beebe, Junli Zhang, Erich Blatter, Solange Gentz, Cynthia Sung, David W. Lafleur, Charles E. Birse, Bernardetta Nardelli, Paul A. Moore, Henrik S. Olsen, Devanshi Shah
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 23(1)
The long half-life and stability of human serum albumin (HSA) make it an attractive candidate for fusion to short-lived therapeutic proteins. Albuferon (Human Genome Sciences [HGS], Inc., Rockville, MD) beta is a novel recombinant protein derived fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4f06a306708a4ddba688097bdf7298
https://pubmed.ncbi.nlm.nih.gov/12639296
https://pubmed.ncbi.nlm.nih.gov/12639296