Zobrazeno 1 - 10
of 21
pro vyhledávání: '"LINU M. JOHN"'
Autor:
Julie M. Jacobsen, Natalia Petersen, Lola Torz, Marina K. Gerstenberg, Kent Pedersen, Søren Østergaard, Birgitte S. Wulff, Birgitte Andersen, Kirsten Raun, Berit Ø. Christoffersen, Linu M. John, Marc L. Reitman, Rune E. Kuhre
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114501- (2024)
Summary: Evaluation of weight loss drugs is usually performed in diet-induced obese mice housed at ∼22°C. This is a cold stress that increases energy expenditure by ∼35% compared to thermoneutrality (∼30°C), which may overestimate drug-induce
Externí odkaz:
https://doaj.org/article/497a3258f3ea4cada07960619cde81b6
Autor:
Linu M. John, Charlotte M. Dalsgaard, Claus B. Jeppesen, Kilian W. Conde-Frieboes, Katrine Baumann, Niels P. H. Knudsen, Per S. Skov, Birgitte S. Wulff
Publikováno v:
Journal of Immunotoxicology, Vol 18, Iss 1, Pp 30-36 (2021)
In development of peptide therapeutics, rodents are commonly-used preclinical models when screening compounds for efficacy endpoints in the early stages of discovery projects. During the screening process, some peptides administered subcutaneously to
Externí odkaz:
https://doaj.org/article/d188a47955b14068b59278fe6234d454
Autor:
Urmas Roostalu, Casper B. G. Salinas, Ditte D. Thorbek, Jacob L. Skytte, Katrine Fabricius, Pernille Barkholt, Linu M. John, Vanessa Isabell Jurtz, Lotte Bjerre Knudsen, Jacob Jelsing, Niels Vrang, Henrik H. Hansen, Jacob Hecksher-Sørensen
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 11 (2019)
Parkinson's disease (PD) is a basal ganglia movement disorder characterized by progressive degeneration of the nigrostriatal dopaminergic system. Immunohistochemical methods have been widely used for characterization of dopaminergic neuronal injury i
Externí odkaz:
https://doaj.org/article/e44ca87b62264255986ad0fa6dfe0e07
Autor:
Kirsten Raun, Linu M. John, Andrea Cabak, Soraya Arrigoni, Sofia Lundh, Christelle Le Foll, Thomas A. Lutz
Publikováno v:
The European Journal of Neuroscience
The role of receptor activity‐modifying proteins (RAMPs) in modulating the pharmacological effects of an amylin receptor selective agonist (NN1213) or the dual amylin–calcitonin receptor agonist (DACRA), salmon calcitonin (sCT), was tested in thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9468a82a270a233da929391cd24c731a
https://doi.org/10.1111/ejn.15376
https://doi.org/10.1111/ejn.15376
Autor:
NATALIA PETERSEN, LOLA TORZ, MARINA K. GERSTENBERG, KENT PEDERSEN, SUZI H. MADSEN, SØREN ØSTERGAARD, BIRGITTE S. WULFF, SEBASTIAN B. JØRGENSEN, BIRGITTE S. ANDERSEN, BERIT Ø. CHRISTOFFERSEN, LINU M. JOHN, RUNE E. KUHRE
Publikováno v:
Diabetes. 71
Objectives: Pre-clinical evaluation of drug efficacy on weight loss is usually done in diet-induced obese (DIO) mice housed at room temperature (∼22°C) , where the mice display adaptive thermogenic responses through brown adipose tissue (BAT) acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bbb22ebf62a0ef59dedd20a33564db1
https://doi.org/10.2337/db22-232-lb
https://doi.org/10.2337/db22-232-lb
Autor:
Charlotte M. Dalsgaard, Katrine Baumann, Niels Peter Hell Knudsen, Kilian Conde-Frieboes, Linu M. John, Claus Bekker Jeppesen, Per Stahl Skov, Birgitte Schjellerup Wulff
Publikováno v:
Journal of Immunotoxicology, Vol 18, Iss 1, Pp 30-36 (2021)
John, L M, Dalsgaard, C M, Jeppesen, C B, Conde-Frieboes, K W, Baumann, K, Knudsen, N P H, Skov, P S & Wulff, B S 2021, ' In vitro prediction of in vivo pseudo-allergenic response via MRGPRX2 ', Journal of Immunotoxicology, vol. 18, no. 1, pp. 30-36 . https://doi.org/10.1080/1547691X.2021.1877375
John, L M, Dalsgaard, C M, Jeppesen, C B, Conde-Frieboes, K W, Baumann, K, Knudsen, N P H, Skov, P S & Wulff, B S 2021, ' In vitro prediction of in vivo pseudo-allergenic response via MRGPRX2 ', Journal of Immunotoxicology, vol. 18, no. 1, pp. 30-36 . https://doi.org/10.1080/1547691X.2021.1877375
In development of peptide therapeutics, rodents are commonly-used preclinical models when screening compounds for efficacy endpoints in the early stages of discovery projects. During the screening process, some peptides administered subcutaneously to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01de45910eac50ecff371132aae52ea4
https://doaj.org/article/d188a47955b14068b59278fe6234d454
https://doaj.org/article/d188a47955b14068b59278fe6234d454
Autor:
Kirsten Raun, Helle Keinicke, Gao Sun, Birgitte Andersen, Merete Fredholm, Linu M. John, Marina Kjaergaard, Caroline M. Junker Mentzel
Publikováno v:
Endocrine Connections, Vol 9, Iss 8, Pp 755-768 (2020)
Endocrine Connections
Keinicke, H, Sun, G, Mentzel, C M J, Fredholm, M, John, L M, Andersen, B, Raun, K & Kjaergaard, M 2020, ' Fgf21 regulates hepatic metabolic pathways to improve steatosis and inflammation ', Endocrine Connections, vol. 9, no. 8, pp. 755-768 . https://doi.org/10.1530/EC-20-0152
Endocrine Connections
Keinicke, H, Sun, G, Mentzel, C M J, Fredholm, M, John, L M, Andersen, B, Raun, K & Kjaergaard, M 2020, ' Fgf21 regulates hepatic metabolic pathways to improve steatosis and inflammation ', Endocrine Connections, vol. 9, no. 8, pp. 755-768 . https://doi.org/10.1530/EC-20-0152
The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased dramatically worldwide and, subsequently, also the risk of developing non-alcoholic steatohepatitis (NASH), hepatic fibrosis, cirrhosis and cancer. Today, weight loss is the on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1b8aa4c65fcc8781460b252b5636c7
https://ec.bioscientifica.com/view/journals/ec/9/8/EC-20-0152.xml
https://ec.bioscientifica.com/view/journals/ec/9/8/EC-20-0152.xml
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 127:163-177
The prevalence of obesity and associated comorbidities such as type 2 diabetes and cardiovascular disease is increasing globally. Body-weight loss reduces the risk of morbidity and mortality in obese individuals, and thus, pharmacotherapies that indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d8200e66d00ad7412a044b38359449
https://doi.org/10.1111/bcpt.13427
https://doi.org/10.1111/bcpt.13427
Autor:
null Soraya Arrigoni, null Christelle Le Foll, null Andrea Cabak, null Sofia Lundh, null Kirsten Raun, null Linu M. John, null Thomas A. Lutz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40049fb99b0136d75ca00e23cb909318
https://doi.org/10.1111/ejn.15376/v2/response1
https://doi.org/10.1111/ejn.15376/v2/response1
Autor:
Per Nørgaard, Jing Su, Jane Boesen Frantzen, Zhiru Yang, Anne Bugge, Chih-Chuan Chang, Linu M. John, Anna Secher, Zhenhua He, Haisun Zhu, Tao Huang, Wei Yang, Kristian Tage Hansen, Xiaoai Wu, Xiang Gao, Sarah J Paulsen, Sebastian Beck Jørgensen, Jacob Jeppesen, Zhe Sun, Linda Yang, Haibin Chen, Bing Shan, Xun Li, Karin Hultman, Jishu Wang, Søren Berg Padkjær, Dennis Madsen
Publikováno v:
Nature Medicine. 23:1158-1166
Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown. Here we show that GD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df7309da29b5ef10acefc642a3c77d83
https://doi.org/10.1038/nm.4394
https://doi.org/10.1038/nm.4394