Zobrazeno 1 - 10
of 3 341
pro vyhledávání: '"LINE‐1"'
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1048-1064 (2024)
Approximately 45% of the human genome is comprised of transposable elements (TEs), also known as mobile genetic elements. However, their biological function remains largely unknown. Among them, retrotransposons are particularly abundant, and some of
Externí odkaz:
https://doaj.org/article/1a39e00d84584774829da252cd64f766
Autor:
Thanit Saeliw, Songphon Kanlayaprasit, Surangrat Thongkorn, Kwanjira Songsritaya, Bumpenporn Sanannam, Depicha Jindatip, Valerie W. Hu, Tewarit Sarachana
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract LINE-1 and Alu retrotransposons are components of the human genome and have been implicated in many human diseases. These elements can influence human transcriptome plasticity in various mechanisms. Chimeric transcripts derived from LINE-1 a
Externí odkaz:
https://doaj.org/article/23124bb14f064ff09c0ed236f712081c
Publikováno v:
Успехи молекулярной онкологии, Vol 11, Iss 2, Pp 85-96 (2024)
Introduction. Local hypermethylation of gene promoters and global genome hypomethylation are well-known manifestations of aberrant methylation associated with carcinogenesis. We investigated this phenomenon as a possible diagnostic marker for liquid
Externí odkaz:
https://doaj.org/article/4e20dce98b7a448881c700f72d25f03b
Publikováno v:
Mobile DNA, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Gene expression divergence between populations and between individuals can emerge from genetic variations within the genes and/or in the cis regulatory elements. Since epigenetic modifications regulate gene expression, it is conce
Externí odkaz:
https://doaj.org/article/5e0ebc100a814e06b7ebf636e2a6faa2
Akademický článek
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Akademický článek
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Autor:
Alessandra Borgognone, Maria Casadellà, María Martínez de Lagrán, Roger Paredes, Bonaventura Clotet, Mara Dierssen, Aleix Elizalde-Torrent
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Elevated activity of retrotransposons is increasingly recognized to be implicated in a wide range of neurodegenerative and neurodevelopmental diseases, including Down syndrome (DS), which is the most common chromosomal condition causing intellectual
Externí odkaz:
https://doaj.org/article/71ae02f3156b434388f72fda1cdfb24c
Autor:
Veronica Tisato, Juliana A. Silva, Fabio Scarpellini, Roberta Capucci, Roberto Marci, Ines Gallo, Francesca Salvatori, Elisabetta D’Aversa, Paola Secchiero, Maria L. Serino, Giorgio Zauli, Ajay V. Singh, Donato Gemmati
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Spontaneous abortion is a pregnancy complication characterized by complex and multifactorial etiology. About 5% of childbearing women are globally affected by early pregnancy loss (EPL) and most of them experience recurrence (RPL). Epigeneti
Externí odkaz:
https://doaj.org/article/75b58436cab84529ae29a1d613d4f356
Autor:
Baohong Xu, Xueer Li, Shaoqi Zhang, Meina Lian, Wenbin Huang, Yin Zhang, Yudong Wang, Zhiquan Huang
Publikováno v:
Mobile DNA, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Long interspersed nuclear element-1 (LINE-1 or L1) comprises 17% of the human genome. As the only autonomous and active retrotransposons, L1 may take part in cancer initiation and progression in some ways. The studies of L1 in can
Externí odkaz:
https://doaj.org/article/fd631f32319e4ed99f3176a3f20ed121
Autor:
Veronica Tisato, Alessandro Castiglione, Andrea Ciorba, Claudia Aimoni, Juliana Araujo Silva, Ines Gallo, Elisabetta D’Aversa, Francesca Salvatori, Chiara Bianchini, Stefano Pelucchi, Paola Secchiero, Giorgio Zauli, Ajay Vikram Singh, Donato Gemmati
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-11 (2023)
Abstract Background Sudden sensorineural hearing loss (SSNHL) is an abrupt loss of hearing, still idiopathic in most of cases. Several mechanisms have been proposed including genetic and epigenetic interrelationships also considering iron homeostasis
Externí odkaz:
https://doaj.org/article/c474315ce2f3488fba66371f2fa879d4