Zobrazeno 1 - 6
of 6
pro vyhledávání: '"LINDSAY J. BAWDEN"'
Autor:
Adam P. Curnock, Giovanna Bossi, Jyothi Kumaran, Lindsay J. Bawden, Rita Figueiredo, Rajeevkumar Tawar, Katherine Wiseman, Emma Henderson, Sec Julie Hoong, Veronica Gonzalez, Hemza Ghadbane, David E.O. Knight, Ronan O’Dwyer, David X. Overton, Christina M. Lucato, Nicola M.G. Smith, Carlos R. Reis, Keith Page, Lorraine M. Whaley, Michelle L. McCully, Stephen Hearty, Tara M. Mahon, Peter Weber
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but progress in this area has been limited. Here, we generated T cell recepto
Externí odkaz:
https://doaj.org/article/76d2b586086f49e3988424380f1b73ad
Autor:
Alan H. Drummond, Andrew Ayscough, Elisabeth A. Bone, Suzanne A. Eccles, L. Michael Wood, Annette Wright, Rajesh Odedra, David Laber, Gary Box, Steve Wood, Thakor Patel, Jo Owen, Valérie Legris, Patricia Kirwin-Jones, Vanessa L. Clark, Stephen Chandler, Juliana Callaghan, Erica Stone, Lauren E.C. Miles, Hannah Farmer, Nicolas Flores, Lindsay J. Bawden, Lindsey A. Needham, David Krige
Supplementary Table 4 from CHR-2797: An Antiproliferative Aminopeptidase Inhibitor that Leads to Amino Acid Deprivation in Human Leukemic Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09283a6bb96997d03f13654b66fe6fa3
https://doi.org/10.1158/0008-5472.22373576
https://doi.org/10.1158/0008-5472.22373576
Autor:
Alan H. Drummond, Andrew Ayscough, Elisabeth A. Bone, Suzanne A. Eccles, L. Michael Wood, Annette Wright, Rajesh Odedra, David Laber, Gary Box, Steve Wood, Thakor Patel, Jo Owen, Valérie Legris, Patricia Kirwin-Jones, Vanessa L. Clark, Stephen Chandler, Juliana Callaghan, Erica Stone, Lauren E.C. Miles, Hannah Farmer, Nicolas Flores, Lindsay J. Bawden, Lindsey A. Needham, David Krige
CHR-2797 is a novel metalloenzyme inhibitor that is converted into a pharmacologically active acid product (CHR-79888) inside cells. CHR-79888 is a potent inhibitor of a number of intracellular aminopeptidases, including leucine aminopeptidase. CHR-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a2ca42194c35dcfa53e5c81a05d9b3
https://doi.org/10.1158/0008-5472.c.6497138
https://doi.org/10.1158/0008-5472.c.6497138
Autor:
Alan H. Drummond, Andrew Ayscough, Elisabeth A. Bone, Suzanne A. Eccles, L. Michael Wood, Annette Wright, Rajesh Odedra, David Laber, Gary Box, Steve Wood, Thakor Patel, Jo Owen, Valérie Legris, Patricia Kirwin-Jones, Vanessa L. Clark, Stephen Chandler, Juliana Callaghan, Erica Stone, Lauren E.C. Miles, Hannah Farmer, Nicolas Flores, Lindsay J. Bawden, Lindsey A. Needham, David Krige
Supplementary Methods and Materials from CHR-2797: An Antiproliferative Aminopeptidase Inhibitor that Leads to Amino Acid Deprivation in Human Leukemic Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cde35dbe728b3cd9eede6ce467677c
https://doi.org/10.1158/0008-5472.22373582
https://doi.org/10.1158/0008-5472.22373582
Autor:
GIOVANNA BOSSI, ADAM P. CURNOCK, PETER WEBER, JYOTHI KUMARAN, LINDSAY J. BAWDEN, RITA FIGUEIREDO, KATHERINE E. WISEMAN, RONAN O’DWYER, DAVID OVERTON, VERONICA GONZALEZ, CHRISTINA M.A. LUCATO, KEITH PAGE, NICOLA SMITH, LORRAINE WHALEY, HEMZA GHADBANE, DAVID KNIGHT, EMMA HENDERSON, STEPHEN HEARTY, TARA MAHON
Publikováno v:
Diabetes. 70
The success of immunosuppressive therapies to preserve pancreatic islets and treat Type 1 Diabetes (T1D) has, so far, been limited either due to safety concerns or lack of persistent efficacy. Restricting T cell suppression to the pancreas, thereby a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::399a5974256669579d03754a11964446
https://doi.org/10.2337/db21-58-lb
https://doi.org/10.2337/db21-58-lb
Publikováno v:
Journal of interferon research. 6(2)
A simple colorimetric assay for estimating cell numbers has been developed based on the observation that the indicator color in cell culture medium is proportional to viable cell number. The assay is performed in multiwell plates to take advantage of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f291afe90299b35c8ed122e60b44e5b0
https://pubmed.ncbi.nlm.nih.gov/2425013
https://pubmed.ncbi.nlm.nih.gov/2425013