Zobrazeno 1 - 10
of 1 257
pro vyhledávání: '"LINC complex"'
Autor:
Xuehuan Meng, Ye Zhu, Hao Tan, Baraa Daraqel, Ye Ming, Xiang Li, Guoyin Yang, Xinyi He, Jinlin Song, Leilei Zheng
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background Periodontal ligament stem cells (PDLSCs) are important seed cells in tissue engineering and clinical applications. They are the priority receptor cells for sensing various mechanical stresses. Yes-associated protein (YAP) is a rec
Externí odkaz:
https://doaj.org/article/ecf01d16ba894a89a98b1b90a05bf960
Publikováno v:
Open Biology, Vol 14, Iss 10 (2024)
The positioning and communication between the nucleus and centrosomes are essential in cell division, differentiation and tissue formation. During skeletal myogenesis, the nuclei become evenly spaced with the switch of the microtubule-organizing cent
Externí odkaz:
https://doaj.org/article/ce475c6a045e43d7983a53fccb3a674e
Autor:
Riccardo Sirtori, Michelle J. Gregoire, Emily M. Potts, Alicia Collins, Liviana Donatelli, Claudia Fallini
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of voluntary muscle control. While the exact cause of ALS is not fully understood, emer
Externí odkaz:
https://doaj.org/article/8b88ef704fdc41188bda66bde4715d39
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract This review presents a comprehensive exploration of the pivotal role played by the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, with a particular focus on Nesprin proteins, in cellular mechanics and the pathogenesis of muscular
Externí odkaz:
https://doaj.org/article/ab69fc3ba7584311a9a0556a20f6eac9
Autor:
Theresa Paulus, Natalie Young, Emily Jessop, Carolin Berwanger, Christoph Stephan Clemen, Rolf Schröder, Rafal Ploski, Christian Hagel, Yorck Hellenbroich, Andreas Moser, Iakowos Karakesisoglou
Publikováno v:
Muscles, Vol 3, Iss 1, Pp 100-109 (2024)
SYNE2 mutations have been associated with skeletal and cardiac muscle diseases, including Emery-Dreifuss muscular dystrophy (EDMD). Here, we present a 70-year-old male patient with muscle pain and elevated serum creatine kinase levels in whom whole-e
Externí odkaz:
https://doaj.org/article/e71a6d2e4cbc420a8756d1031e1da6dd
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
Accumulating evidence suggests that the nuclear envelope (NE) is not just a target, but also a mediator of apoptosis. We showed recently that the NE protein nesprin-2 has pro-apoptotic activity, which involves its subcellular redistribution and Bcl-2
Externí odkaz:
https://doaj.org/article/066e03b35ad44175a57b70a7ec0ab7c4
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
The nucleus not only is a repository for DNA but also a center of cellular and nuclear mechanotransduction. From nuclear deformation to the interplay between mechanosensing components and genetic control, the nucleus is poised at the nexus of mechani
Externí odkaz:
https://doaj.org/article/69b0f1644f2b4919a922f43fa0f9bbef
Autor:
Joana T. Lima, Jorge G. Ferreira
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
Cellular behavior is continuously influenced by mechanical forces. These forces span the cytoskeleton and reach the nucleus, where they trigger mechanotransduction pathways that regulate downstream biochemical events. Therefore, the nucleus has emerg
Externí odkaz:
https://doaj.org/article/7958364dff7d47f7bedb23bc42c40d5c
Autor:
Pauline Bougaran, Victoria L. Bautch
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Vascular endothelial cells line the inner surface of all blood vessels, where they are exposed to polarized mechanical forces throughout their lifespan. Both basal substrate interactions and apical blood flow-induced shear stress regulate blood vesse
Externí odkaz:
https://doaj.org/article/40cc4ca91caf4212b798d6767006b4ff
Autor:
Natalie Young, Zizhao Gui, Suleiman Mustafa, Kleopatra Papa, Emily Jessop, Elizabeth Ruddell, Laura Bevington, Roy A. Quinlan, Adam M. Benham, Martin W. Goldberg, Boguslaw Obara, Iakowos Karakesisoglou
Publikováno v:
Cells, Vol 13, Iss 11, p 906 (2024)
Eukaryotic cells tether the nucleoskeleton to the cytoskeleton via a conserved molecular bridge, called the LINC complex. The core of the LINC complex comprises SUN-domain and KASH-domain proteins that directly associate within the nuclear envelope l
Externí odkaz:
https://doaj.org/article/c97d31bf16a348109f2b4e6bd75f54e5